> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pgf-4fda0322-a74e-5a50-9f97-af000c418e8b > Record changed: 2026-10-13 # PGF ENSG00000119630 Target class Secreted protein Chromosome 14 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** PGF **Gene name** Placental growth factor **Gene symbol** PGF **Previous gene symbols** - PGFL **Protein name** Placenta growth factor (PlGF) ### Other names (6) - PlGF-2 - SHGC-10760 - D12S1900 - PIGF - PLGF - PlGF ## Classification **Gene biotype** Protein coding **Gene family** VEGF family **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 90.73 **Tissue specificity (Gini)** 0.535 **Tissue specificity (tau)** 0.858 ## Pathways and interactions **KEGG gene identifiers** - hsa:5228 **Protein interaction confidence** 0.823175 **Protein interaction partners** 40 ### Reactome pathways (2) - R-HSA-194313 - R-HSA-195399 ## Genomic location **End position** 74955626 **Start position** 74941830 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000119630 **HGNC ID** HGNC:8893 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8893) **NCBI Gene ID** 5228 **UniProt ID** P49763 ## Cellular location - Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. - Cytosol - Mitochondria - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.858307 **Expression inequality (Gini)** 0.5354 ### Highest expression Expression in transcripts per million **Thyroid** 90.73 **Artery - Tibial** 81.09 **Artery - Coronary** 51.72 **Artery - Aorta** 38.87 **Cervix - Endocervix** 37.94 ### All tissues (54) Expression in transcripts per million - Thyroid90.73 - Artery - Tibial81.09 - Artery - Coronary51.72 - Artery - Aorta38.87 - Cervix - Endocervix37.94 - Fallopian Tube33.99 - Cervix - Ectocervix33.66 - Prostate23.32 - Nerve - Tibial23.07 - Vagina19.61 - Skin - Sun Exposed (Lower leg)18.01 - Bladder17.78 - Esophagus - Muscularis17.19 - Adipose - Subcutaneous16.45 - Breast - Mammary Tissue16.25 - Skin - Not Sun Exposed (Suprapubic)16.14 - Small Intestine - Terminal Ileum14.99 - Esophagus - Gastroesophageal Junction14.87 - Adipose - Visceral (Omentum)13.98 - Uterus13.61 - Minor Salivary Gland12.38 - Esophagus - Mucosa10.88 - Lung10.42 - Brain - Hypothalamus7.95 - Colon - Sigmoid7.49 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) ### Cellular components - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) ## Related records ### Trials (502) - 24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME. - 3 Month Outcome of Ziv-aflibercept for DME - 4D-150 in Patients With Diabetic Macular Edema - 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration - 4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration - 5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer - A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56 - A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUGANO) Primary Efficacy Will be Determined at Week 56 - A 24 Month Phase 2a Open Label, Randomized Study of Avastin®, Lucentis®, or Eylea® (Anti-VEGF Therapy) Administered in Combination With Fovista® (Anti-PDGF BB Pegylated Aptamer) - A Clinical Study of QL1207H Injection Versus Aflibercept for Neovascular Age-related Macular Degeneration - A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-90b89db5-5302-42fb-ba5b-3d3437205ca8.md) - [A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)](https://trialight.com/data/trial/a-clinical-trial-of-eye201-mk-8748-in-people-with-macular-ea138d8e-cfd4-45eb-a9cb-06686d6d126d.md) - A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004) - [A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)](https://trialight.com/data/trial/a-clinical-trial-of-mk-8748-compared-to-aflibercept-in-3ef6f171-2f7a-49f8-9de8-748b56da6e0d.md) - A Comparison of Ranibizumab and Aflibercept for the Development of Geographic Atrophy in (Wet) AMD Patients - A Depot Formulation of Sunitinib Malate (GB-102) Compared to Aflibercept in Subjects With Wet AMD - A Depot Formulation of Sunitinib Malate (GB-102) in Subjects With Neovascular (Wet) Age-related Macular Degeneration - A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema - A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO ### Drugs (3) - [Aflibercept](https://trialight.com/data/asset/aflibercept-6bb09e87-ca99-436b-8634-71b90510b8fb.md) Placenta growth factor inhibitor - Conbercept Placenta growth factor inhibitor - TB-403 Placenta growth factor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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