> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pdgfrb-b0fcbfa5-50cf-5648-aa6d-c7487708468d > Record changed: 2026-10-13 # PDGFRB ENSG00000113721 Target class Kinase Chromosome 5 Approved drugs 12 Clinical candidates (approved and in development) 42 ## Clinical evidence **Approved drugs** 12 **Clinical candidates (approved and in development)** 42 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDGFRB **Gene name** Platelet derived growth factor receptor beta **Gene symbol** PDGFRB **Previous gene symbols** - PDGFR **Protein name** Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b) ### Other names (3) - JTK12 - CD140b - PDGFR1 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 398.15 **Tissue specificity (Gini)** 0.556 **Tissue specificity (tau)** 0.767 ## Pathways and interactions **KEGG gene identifiers** - hsa:5159 **Protein interaction confidence** 0.83998 **Protein interaction partners** 151 ### Reactome pathways (6) - R-HSA-1257604 - R-HSA-186763 - R-HSA-186797 - R-HSA-2219530 - R-HSA-5673001 - R-HSA-6811558 ## Genomic location **End position** 150158260 **Start position** 150113839 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113721 **HGNC ID** HGNC:8804 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8804) **NCBI Gene ID** 5159 **UniProt ID** P09619 ## Cellular location - Cell membrane - Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. - Golgi apparatus - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.76668 **Expression inequality (Gini)** 0.556031 ### Highest expression Expression in transcripts per million **Cervix - Ectocervix** 398.15 **Cervix - Endocervix** 353.6 **Artery - Tibial** 346.19 **Adipose - Subcutaneous** 303.23 **Artery - Coronary** 277.75 ### All tissues (54) Expression in transcripts per million - Cervix - Ectocervix398.15 - Cervix - Endocervix353.6 - Artery - Tibial346.19 - Adipose - Subcutaneous303.23 - Artery - Coronary277.75 - Artery - Aorta273.44 - Cells - Cultured fibroblasts256.81 - Uterus245.58 - Fallopian Tube217.97 - Ovary210.61 - Adipose - Visceral (Omentum)187.13 - Nerve - Tibial183.26 - Lung182.71 - Breast - Mammary Tissue182.18 - Vagina163.28 - Thyroid141.71 - Bladder103.82 - Prostate101.61 - Esophagus - Gastroesophageal Junction97.89 - Skin - Sun Exposed (Lower leg)96.09 - Esophagus - Muscularis91.51 - Colon - Sigmoid68.57 - Spleen65.29 - Skin - Not Sun Exposed (Suprapubic)55.56 - Small Intestine - Terminal Ileum54.68 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0014911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014911) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0035791 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035791) - GO:0038091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038091) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048008) - GO:0048661 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048661) - GO:0050850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050850) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0060326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (14) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004992 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004992) - GO:0005017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005017) - GO:0005019 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005019) - GO:0005096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005096) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005161) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0038085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038085) - GO:0048407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048407) - GO:0160185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160185) ## On-target safety - heart disease ### Studies - preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: β isoform is crucial in angiogenesis and heart’s response to pressure overload ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) ## Related records ### Trials (3,291) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC - 4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma - 5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk ### Drugs (50) - Becaplermin Platelet-derived growth factor receptor agonist - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Platelet-derived growth factor receptor beta inhibitor - CDP-860 Platelet-derived growth factor receptor beta inhibitor - Cediranib Platelet-derived growth factor receptor inhibitor - CEP-2563 Platelet-derived growth factor receptor beta inhibitor - Cep-2563 dihydrochloride Platelet-derived growth factor receptor beta inhibitor - CM-082 Platelet-derived growth factor receptor beta inhibitor - Crenolanib Platelet-derived growth factor receptor inhibitor - Dasatinib anhydrous Platelet-derived growth factor receptor beta inhibitor - Dovitinib Platelet-derived growth factor receptor inhibitor - ENMD-981693 Platelet-derived growth factor receptor inhibitor - Famitinib Platelet-derived growth factor receptor inhibitor - Foretinib Platelet-derived growth factor receptor inhibitor - Ilorasertib Platelet-derived growth factor receptor inhibitor - Imatinib Platelet-derived growth factor receptor beta inhibitor - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Platelet-derived growth factor receptor beta inhibitor - JI-101 Platelet-derived growth factor receptor beta inhibitor - Linifanib Platelet-derived growth factor receptor inhibitor - Masitinib Platelet-derived growth factor receptor inhibitor - Midostaurin Platelet-derived growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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