PDGFRB

ENSG00000113721
Target class
Kinase
Chromosome
5
Approved drugs
12
Clinical candidates (approved and in development)
42

Approved drugs
12
Clinical candidates (approved and in development)
42

Chemical probe available
Yes

Target name
PDGFRB
Gene name
Platelet derived growth factor receptor beta
Gene symbol
PDGFRB
Previous gene symbols
  • PDGFR
Protein name
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

  • JTK12
  • CD140b
  • PDGFR1

Gene biotype
Protein coding
Gene family
Receptor tyrosine kinases|CD molecules|I-set domain containing
Target class
Kinase
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Supported
Highest tissue expression
398.15
Tissue specificity (Gini)
0.556
Tissue specificity (tau)
0.767

KEGG gene identifiers
  • hsa:5159
Protein interaction confidence
0.83998
Protein interaction partners
151

  • R-HSA-1257604
  • R-HSA-186763
  • R-HSA-186797
  • R-HSA-2219530
  • R-HSA-5673001
  • R-HSA-6811558

End position
150158260
Start position
150113839
Chromosome
5
Strand
Reverse

Ensembl gene ID
ENSG00000113721
HGNC ID
HGNC:8804
www.genenames.org
NCBI Gene ID
5159
UniProt ID
P09619

  • Cell membrane
  • Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
  • Golgi apparatus
  • Vesicles

Tissue specificity (tau)
0.76668
Expression inequality (Gini)
0.556031

Expression in transcripts per million

Cervix - Ectocervix
398.15
Cervix - Endocervix
353.6
Artery - Tibial
346.19
Adipose - Subcutaneous
303.23
Artery - Coronary
277.75

Expression in transcripts per million

  • Cervix - Ectocervix398.15
  • Cervix - Endocervix353.6
  • Artery - Tibial346.19
  • Adipose - Subcutaneous303.23
  • Artery - Coronary277.75
  • Artery - Aorta273.44
  • Cells - Cultured fibroblasts256.81
  • Uterus245.58
  • Fallopian Tube217.97
  • Ovary210.61
  • Adipose - Visceral (Omentum)187.13
  • Nerve - Tibial183.26
  • Lung182.71
  • Breast - Mammary Tissue182.18
  • Vagina163.28
  • Thyroid141.71
  • Bladder103.82
  • Prostate101.61
  • Esophagus - Gastroesophageal Junction97.89
  • Skin - Sun Exposed (Lower leg)96.09
  • Esophagus - Muscularis91.51
  • Colon - Sigmoid68.57
  • Spleen65.29
  • Skin - Not Sun Exposed (Suprapubic)55.56
  • Small Intestine - Terminal Ileum54.68

And 29 more, listed on the interactive page.

  • heart disease

    Studies

    • preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: β isoform is crucial in angiogenesis and heart’s response to pressure overload

    Biological samples

    • cardiovascular system
    PubMed 21283106
    pubmed.ncbi.nlm.nih.gov

Related records

Trials (3,291)

Drugs (50)