> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pdgfra-9af831a8-8fd9-5e16-8799-a31d1bc6c91f > Record changed: 2026-10-13 # PDGFRA ENSG00000134853 Target class Kinase Chromosome 4 Approved drugs 11 Clinical candidates (approved and in development) 31 ## Clinical evidence **Approved drugs** 11 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 31 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDGFRA **Gene name** Platelet derived growth factor receptor alpha **Gene symbol** PDGFRA **Protein name** Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a) ### Other names (3) - CD140a - PDGFR2 - GAS9 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Approved **Highest tissue expression** 217.53 **Tissue specificity (Gini)** 0.526 **Tissue specificity (tau)** 0.854 ## Pathways and interactions **KEGG gene identifiers** - hsa:5156 **Protein interaction confidence** 0.83331 **Protein interaction partners** 142 ### Reactome pathways (13) - R-HSA-1257604 - R-HSA-186763 - R-HSA-186797 - R-HSA-2219530 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-9673767 - R-HSA-9673770 - R-HSA-9674396 - R-HSA-9674401 - R-HSA-9674403 - R-HSA-9674404 - R-HSA-9674428 ## Genomic location **End position** 54298246 **Start position** 54229130 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000134853 **HGNC ID** HGNC:8803 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8803) **NCBI Gene ID** 5156 **UniProt ID** P16234 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Cell projection, cilium . Golgi apparatus . - Cell Junctions - Plasma membrane ### Publication evidence (3) - PubMed 14644164 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14644164/) - PubMed 2554309 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2554309/) - PubMed 8188664 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8188664/) ## Tissue expression **Tissue specificity (tau)** 0.854478 **Expression inequality (Gini)** 0.525696 ### Highest expression Expression in transcripts per million **Ovary** 217.53 **Cells - Cultured fibroblasts** 164.2 **Cervix - Endocervix** 100.04 **Fallopian Tube** 89.11 **Uterus** 77.46 ### All tissues (54) Expression in transcripts per million - Ovary217.53 - Cells - Cultured fibroblasts164.2 - Cervix - Endocervix100.04 - Fallopian Tube89.11 - Uterus77.46 - Artery - Aorta68.26 - Bladder66.16 - Spleen61.62 - Artery - Coronary61.21 - Lung60.92 - Vagina58.17 - Cervix - Ectocervix56.03 - Adipose - Visceral (Omentum)54.55 - Colon - Sigmoid52.72 - Adipose - Subcutaneous52.11 - Esophagus - Gastroesophageal Junction52.02 - Breast - Mammary Tissue42.53 - Nerve - Tibial41.97 - Esophagus - Muscularis40.42 - Small Intestine - Terminal Ileum38.01 - Colon - Transverse35.66 - Artery - Tibial34.32 - Thyroid27.91 - Stomach24.67 - Heart - Atrial Appendage21.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (18) - GO:0001775 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001775) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010544 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010544) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0032956 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032956) - GO:0034614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034614) - GO:0035790 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035790) - GO:0038091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038091) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048008) - GO:0048146 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048146) - GO:0050850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050850) - GO:0050921 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050921) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0070527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070527) - GO:2000739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000739) ### Cellular components (4) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) ### Molecular functions (10) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005018) - GO:0005021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005021) - GO:0005161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005161) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0038085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038085) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0048407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048407) - GO:0160185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160185) ## Related records ### Trials (1,696) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies - (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors - (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC ### Drugs (33) - Amuvatinib Platelet-derived growth factor receptor alpha inhibitor - Avapritinib Platelet-derived growth factor receptor alpha inhibitor - Becaplermin Platelet-derived growth factor receptor agonist - Cediranib Platelet-derived growth factor receptor inhibitor - Crenolanib Platelet-derived growth factor receptor inhibitor - Dovitinib Platelet-derived growth factor receptor inhibitor - ENMD-981693 Platelet-derived growth factor receptor inhibitor - Famitinib Platelet-derived growth factor receptor inhibitor - Foretinib Platelet-derived growth factor receptor inhibitor - Ilorasertib Platelet-derived growth factor receptor inhibitor - Linifanib Platelet-derived growth factor receptor inhibitor - Masitinib Platelet-derived growth factor receptor inhibitor - Midostaurin Platelet-derived growth factor receptor inhibitor - Motesanib Platelet-derived growth factor receptor inhibitor - Nintedanib Platelet-derived growth factor receptor inhibitor - Nintedanib esylate Platelet-derived growth factor receptor inhibitor - Olaratumab Platelet-derived growth factor receptor alpha antagonist - Orantinib Platelet-derived growth factor receptor inhibitor - Pazopanib Platelet-derived growth factor receptor inhibitor - Pazopanib hydrochloride Platelet-derived growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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