> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde9a-77bc51ad-da74-5414-a8bc-1854411e630e > Record changed: 2026-10-13 # PDE9A ENSG00000160191 Target class Enzyme Chromosome 21 Approved drugs 2 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDE9A **Gene name** Phosphodiesterase 9A **Gene symbol** PDE9A **Protein name** High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Supported **Highest tissue expression** 93.22 **Tissue specificity (Gini)** 0.515 **Tissue specificity (tau)** 0.853 ## Pathways and interactions **KEGG gene identifiers** - hsa:5152 **Reactome pathways** - R-HSA-418457 **Protein interaction confidence** 0.798667 **Protein interaction partners** 27 ## Genomic location **End position** 42775513 **Start position** 42653591 **Chromosome** 21 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000160191 **HGNC ID** HGNC:8795 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8795) **NCBI Gene ID** 5152 **UniProt ID** O76083 ## Cellular location - \[Isoform PDE9A1\]: Cell projection, ruffle membrane . Cytoplasm, perinuclear region . Golgi apparatus . Endoplasmic reticulum . Cell membrane, sarcolemma . - SUBCELLULAR LOCATION: \[Isoform PDE9A2\]: Cell projection, ruffle membrane . Cytoplasm, perinuclear region . - SUBCELLULAR LOCATION: \[Isoform PDE9A3\]: Cytoplasm . Endoplasmic reticulum . - SUBCELLULAR LOCATION: \[Isoform PDE9A17\]: Cytoplasm . Endoplasmic reticulum . - Cytosol - Plasma membrane ### Publication evidence (2) - PubMed 17090334 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17090334/) - PubMed 25799991 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25799991/) ## Tissue expression **Tissue specificity (tau)** 0.852848 **Expression inequality (Gini)** 0.51528 ### Highest expression Expression in transcripts per million **Colon - Sigmoid** 93.22 **Colon - Transverse** 74.98 **Prostate** 52.56 **Small Intestine - Terminal Ileum** 47.82 **Nerve - Tibial** 47.03 ### All tissues (54) Expression in transcripts per million - Colon - Sigmoid93.22 - Colon - Transverse74.98 - Prostate52.56 - Small Intestine - Terminal Ileum47.82 - Nerve - Tibial47.03 - Esophagus - Muscularis32.61 - Kidney - Medulla31.11 - Brain - Cerebellum24.18 - Brain - Cerebellar Hemisphere22.09 - Spleen21.74 - Esophagus - Gastroesophageal Junction21.65 - Bladder18.87 - Brain - Putamen (basal ganglia)15.72 - Minor Salivary Gland15.45 - Brain - Caudate (basal ganglia)14.65 - Breast - Mammary Tissue14.57 - Pituitary13.89 - Fallopian Tube12.6 - Adipose - Subcutaneous12.49 - Cervix - Endocervix12.49 - Cervix - Ectocervix11.93 - Adrenal Gland11.26 - Adipose - Visceral (Omentum)11.25 - Brain - Substantia nigra11.15 - Brain - Spinal cord (cervical c-1)10.97 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0046068 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046068) - GO:0046069 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046069) ### Cellular components (6) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0042383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042383) ### Molecular functions (3) - GO:0004114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004114) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0047555 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047555) ## Related records ### Trials (268) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - A Brief Study To Evaluate The Safety, Tolerability, And Blood Levels Of Multiple Doses Of PF-044467943 Or Placebo In Combination With Donepezil In Subjects With Mild To Moderate Alzheimer's Disease - A Phase I, Multiple Dose Study of PF-04447943 in Healthy Elderly Volunteers - A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis - A Safety Study of Pentoxifylline for the Treatment of Anemia - A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole - A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine - A Study of E2027 in Participants With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) With or Without Amyloid Copathology - A Study of IMR-687 in Adult Participants With Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia) - A Study of IMR-687 in Healthy Adult Volunteers - A Study of IMR-687 in Subjects With Beta Thalassemia - A Study of IMR-687 in Subjects With Sickle Cell Disease - A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease - [A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)](https://trialight.com/data/trial/a-study-to-assess-safety-effectiveness-of-tovinontrine-in-a502fdf6-1cf8-4a89-a30d-2a699a7e703f.md) - A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2027 in Healthy Subjects - A Study to Determine the Metabolism and Elimination of \[14C\]E2027 in Healthy Male Participants - A Study to Evaluate Safety, Tolerability, Plasma Drug Levels, and Cognitive Response Following Multiple Doses of a Drug in Healthy Elderly Participants. - A Study To Evaluate The Effect Of PF-04447943 On Qtc Interval In Healthy Adult Subjects - A Study To Evaluate The Safety, Tolerability And Plasma Drug Levels Of PF-04447943 When Administered With Donepezil To Healthy Volunteer Subjects ### Drugs (6) - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Edelinontrine Phosphodiesterase 9A inhibitor - Irsenontrine Phosphodiesterase 9A inhibitor - Osoresnontrine Phosphodiesterase 9A inhibitor - Pentoxifylline 3',5'-cyclic phosphodiesterase inhibitor - [Tovinontrine](https://trialight.com/data/asset/tovinontrine-ff9f7ef0-b403-4b10-aaee-d81896455f2e.md) Phosphodiesterase 9A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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