> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde5a-d88f07a6-9f4e-5047-8ef0-e11894ff0f51 > Record changed: 2026-10-13 # PDE5A ENSG00000138735 Target class Enzyme Chromosome 4 Approved drugs 7 Clinical candidates (approved and in development) 11 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 11 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDE5A **Gene name** Phosphodiesterase 5A **Gene symbol** PDE5A **Protein name** cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Approved **Highest tissue expression** 81.89 **Tissue specificity (Gini)** 0.644 **Tissue specificity (tau)** 0.852 ## Pathways and interactions **KEGG gene identifiers** - hsa:8654 **Protein interaction confidence** 0.822441 **Protein interaction partners** 34 ### Reactome pathways (3) - R-HSA-418457 - R-HSA-445355 - R-HSA-9013422 ## Genomic location **End position** 119628804 **Start position** 119494397 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000138735 **HGNC ID** HGNC:8784 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8784) **NCBI Gene ID** 8654 **UniProt ID** O76074 ## Cellular location - Basal body - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.851649 **Expression inequality (Gini)** 0.644473 ### Highest expression Expression in transcripts per million **Artery - Aorta** 81.89 **Artery - Tibial** 67.07 **Esophagus - Muscularis** 57.57 **Esophagus - Gastroesophageal Junction** 55.83 **Colon - Sigmoid** 49.22 ### All tissues (54) Expression in transcripts per million - Artery - Aorta81.89 - Artery - Tibial67.07 - Esophagus - Muscularis57.57 - Esophagus - Gastroesophageal Junction55.83 - Colon - Sigmoid49.22 - Artery - Coronary44.62 - Cervix - Ectocervix43.93 - Cervix - Endocervix26.65 - Prostate26.65 - Fallopian Tube22.39 - Nerve - Tibial19.34 - Vagina19.29 - Lung18.91 - Adipose - Subcutaneous18.44 - Colon - Transverse17.42 - Bladder16.01 - Thyroid15.66 - Breast - Mammary Tissue11.98 - Uterus11.3 - Small Intestine - Terminal Ileum8.71 - Adipose - Visceral (Omentum)7.95 - Testis7.19 - Skin - Sun Exposed (Lower leg)5.57 - Ovary5.43 - Minor Salivary Gland4.76 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030553 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030553) - GO:0047555 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047555) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hPDE5, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hPDE5 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,012) - "As Required" Oral Sildenafil in Raynaud's Phenomenon - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Bioavailability Study of LY2452473 and Tadalafil - A Bioequivalence Study of Sildenafil Citrate Orally-Disintegrating Film Dosage Form - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis - A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers - A Dose Escalation Study to Evaluate the Effect of RT234 in Subjects With Pulmonary Arterial Hypertension - A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure - A Double-blind "Preferred" Vardenafil Dose Study of QoL and Functional Outcomes in Males With Erectile Dysfunction - A Extension Study of Udenafil in Adolescents - A Healthy Volunteer Study Evaluating the the Safety, Tolerability, and Pharmacokinetics of RT234 - A Long Term Extension Study Evaluating Safety Of Sildenafil Citrate When Used To Treat Pulmonary Arterial Hypertension (PAH) In Children - A Multicenter, Double-blind Study to Evaluate the Effect of Pretreatment With a Daily Dose of Sildenafil on the As-Needed Efficacy of Viagra in Men With Erectile Dysfunction and Type 2 Diabetes - A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction. - A Multicenter, Randomized, Parallel Group, Double-Blind, Placebo Controlled, Flexible Dose Escalation Study To Evaluate Sexual And Relationship Satisfaction In The Female Partner Of Men With Erectile Dysfunction Treated With Sildenafil Citrate - A Multicentre, Prospective, Open-label, Non-comparative Study ### Drugs (13) - Avanafil Phosphodiesterase 5A inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Gisadenafil Phosphodiesterase 5A inhibitor - Ibudilast Phosphodiesterase 5A inhibitor - Pentoxifylline 3',5'-cyclic phosphodiesterase inhibitor - PF-00489791 Phosphodiesterase 5A inhibitor - PF-03049423 Phosphodiesterase 5A inhibitor - Sildenafil Phosphodiesterase 5A inhibitor - Sildenafil citrate Phosphodiesterase 5A inhibitor - [Tadalafil](https://trialight.com/data/asset/tadalafil-4b34b94f-a4f3-4c9a-a187-9910e81423ab.md) Phosphodiesterase 5A inhibitor - Udenafil Phosphodiesterase 5A inhibitor - Vardenafil Phosphodiesterase 5A inhibitor - Vardenafil hydrochloride Phosphodiesterase 5A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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