> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde4c-430120be-12f2-5dfe-b97a-576e1cbfef79 > Record changed: 2026-10-13 # PDE4C ENSG00000105650 Target class Enzyme Chromosome 19 Approved drugs 14 Clinical candidates (approved and in development) 28 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 28 ## Druggability **Chemical probe available** No ## Names **Target name** PDE4C **Gene name** Phosphodiesterase 4C **Gene symbol** PDE4C **Previous gene symbols** - DPDE1 **Protein name** 3',5'-cyclic-AMP phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) (cAMP-specific phosphodiesterase 4C) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Protein localisation evidence grade** Approved **Highest tissue expression** 5.75 **Tissue specificity (Gini)** 0.438 **Tissue specificity (tau)** 0.691 ## Pathways and interactions **KEGG gene identifiers** - hsa:5143 **Protein interaction confidence** 0.87525 **Protein interaction partners** 4 ### Reactome pathways (2) - R-HSA-180024 - R-HSA-418555 ## Genomic location **End position** 18248200 **Start position** 18207965 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000105650 **HGNC ID** HGNC:8782 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8782) **NCBI Gene ID** 5143 **UniProt ID** Q08493 ## Cellular location - Cell projection, cilium . - Basal body - Centrosome - Cytosol - Midbody ring ## Tissue expression **Tissue specificity (tau)** 0.690894 **Expression inequality (Gini)** 0.438425 ### Highest expression Expression in transcripts per million **Colon - Transverse** 5.75 **Artery - Tibial** 5.12 **Fallopian Tube** 4.83 **Colon - Sigmoid** 4.34 **Brain - Cortex** 4.09 ### All tissues (54) Expression in transcripts per million - Colon - Transverse5.75 - Artery - Tibial5.12 - Fallopian Tube4.83 - Colon - Sigmoid4.34 - Brain - Cortex4.09 - Stomach4.06 - Artery - Coronary3.92 - Kidney - Medulla3.89 - Testis3.79 - Lung3.76 - Cervix - Endocervix3.56 - Uterus3.43 - Cervix - Ectocervix3.34 - Pituitary3.3 - Brain - Frontal Cortex (BA9)2.98 - Small Intestine - Terminal Ileum2.45 - Spleen2.3 - Prostate2.13 - Esophagus - Gastroesophageal Junction1.87 - Brain - Anterior cingulate cortex (BA24)1.86 - Ovary1.8 - Esophagus - Mucosa1.61 - Vagina1.53 - Thyroid1.53 - Nerve - Tibial1.43 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) ## Related records ### Trials (771) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A 20-Week Study Assessing the Efficacy of Apremilast in Patients with EB Simplex Generalized - A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD - A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis - A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore: - A Clinical Study of Oglemilast in Patients With Mild to Moderate Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis - A Comparison Study Between Adolescents With Asthma and Adults With Asthma on How They Absorb, Metabolise and Eliminate CHF 6001 - A Dose-finding and Confirmatory Trial of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast - A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis ### Drugs (31) - Aminophylline Phosphodiesterase 4 inhibitor - Amlexanox Phosphodiesterase 4 inhibitor - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) Phosphodiesterase 4 inhibitor - Cilomilast Phosphodiesterase 4 inhibitor - Crisaborole Phosphodiesterase 4 inhibitor - Difamilast Phosphodiesterase 4 inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Dovramilast Phosphodiesterase 4 inhibitor - Drotaverine Phosphodiesterase 4 inhibitor - Dyphylline Phosphodiesterase 4 inhibitor - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) Phosphodiesterase 4 inhibitor - Flavoxate Phosphodiesterase 4 inhibitor - Flavoxate hydrochloride Phosphodiesterase 4 inhibitor - GSK-256066 Phosphodiesterase 4 inhibitor - HT-0712 Phosphodiesterase 4 inhibitor - Ibudilast Phosphodiesterase 4 inhibitor - Lotamilast Phosphodiesterase 4 inhibitor - MK-0873 Phosphodiesterase 4 inhibitor - Oglemilast Phosphodiesterase 4 inhibitor - Oxtriphylline Phosphodiesterase 4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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