> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde4b-b6d2dead-6de9-505a-b969-9b1362d0de89 > Record changed: 2026-10-13 # PDE4B ENSG00000184588 Target class Enzyme Chromosome 1 Approved drugs 14 Clinical candidates (approved and in development) 28 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 28 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDE4B **Gene name** Phosphodiesterase 4B **Gene symbol** PDE4B **Previous gene symbols** - DPDE4 **Protein name** 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 26.68 **Tissue specificity (Gini)** 0.37 **Tissue specificity (tau)** 0.707 ## Pathways and interactions **KEGG gene identifiers** - hsa:5142 **Protein interaction confidence** 0.815486 **Protein interaction partners** 35 ## Genomic location **End position** 66374579 **Start position** 65792514 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000184588 **HGNC ID** HGNC:8781 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8781) **NCBI Gene ID** 5142 **UniProt ID** Q07343 ## Cellular location - \[Isoform PDE4B5\]: Cytoplasm . Cell membrane . - Cytosol - Golgi apparatus ### Publication evidence - PubMed 17519386 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17519386/) ## Tissue expression **Tissue specificity (tau)** 0.706628 **Expression inequality (Gini)** 0.369847 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 26.68 **Brain - Nucleus accumbens (basal ganglia)** 16.35 **Brain - Substantia nigra** 15.75 **Brain - Frontal Cortex (BA9)** 15.58 **Brain - Hypothalamus** 14.88 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)26.68 - Brain - Nucleus accumbens (basal ganglia)16.35 - Brain - Substantia nigra15.75 - Brain - Frontal Cortex (BA9)15.58 - Brain - Hypothalamus14.88 - Brain - Caudate (basal ganglia)14.81 - Spleen14.8 - Brain - Cortex14.68 - Lung13.81 - Brain - Hippocampus13.8 - Brain - Amygdala13.72 - Brain - Putamen (basal ganglia)13.48 - Cells - EBV-transformed lymphocytes13.21 - Brain - Cerebellum12.7 - Adipose - Subcutaneous12.27 - Breast - Mammary Tissue12.1 - Artery - Tibial11.96 - Prostate11.72 - Brain - Cerebellar Hemisphere10.71 - Brain - Anterior cingulate cortex (BA24)10.71 - Adipose - Visceral (Omentum)10.48 - Minor Salivary Gland8.9 - Heart - Atrial Appendage8.78 - Small Intestine - Terminal Ileum8.02 - Artery - Aorta7.96 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0032729 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032729) - GO:0032743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032743) - GO:0050852 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050852) ### Cellular components (3) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030552 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030552) ## Related records ### Trials (771) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A 20-Week Study Assessing the Efficacy of Apremilast in Patients with EB Simplex Generalized - A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD - A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis - A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore: - A Clinical Study of Oglemilast in Patients With Mild to Moderate Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis - A Comparison Study Between Adolescents With Asthma and Adults With Asthma on How They Absorb, Metabolise and Eliminate CHF 6001 - A Dose-finding and Confirmatory Trial of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast - A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis ### Drugs (31) - Aminophylline Phosphodiesterase 4 inhibitor - Amlexanox Phosphodiesterase 4 inhibitor - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) Phosphodiesterase 4 inhibitor - Cilomilast Phosphodiesterase 4 inhibitor - Crisaborole Phosphodiesterase 4 inhibitor - Difamilast Phosphodiesterase 4 inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Dovramilast Phosphodiesterase 4 inhibitor - Drotaverine Phosphodiesterase 4 inhibitor - Dyphylline Phosphodiesterase 4 inhibitor - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) Phosphodiesterase 4 inhibitor - Flavoxate Phosphodiesterase 4 inhibitor - Flavoxate hydrochloride Phosphodiesterase 4 inhibitor - GSK-256066 Phosphodiesterase 4 inhibitor - HT-0712 Phosphodiesterase 4 inhibitor - Ibudilast Phosphodiesterase 4 inhibitor - Lotamilast Phosphodiesterase 4 inhibitor - MK-0873 Phosphodiesterase 4 inhibitor - Oglemilast Phosphodiesterase 4 inhibitor - Oxtriphylline Phosphodiesterase 4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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