PDE4B
ENSG00000184588
Target class
Enzyme
Chromosome
1
Approved drugs
14
Clinical candidates (approved and in development)
28
- Approved drugs
- 14
- Clinical candidates (approved and in development)
- 28
- Chemical probe available
- Yes
- Target name
- PDE4B
- Gene name
- Phosphodiesterase 4B
- Gene symbol
- PDE4B
- Previous gene symbols
- DPDE4
- Protein name
- 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)
- Gene biotype
- Protein coding
- Gene family
- Phosphodiesterases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 53
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 26.68
- Tissue specificity (Gini)
- 0.37
- Tissue specificity (tau)
- 0.707
- KEGG gene identifiers
- hsa:5142
- Protein interaction confidence
- 0.815486
- Protein interaction partners
- 35
- End position
- 66374579
- Start position
- 65792514
- Chromosome
- 1
- Strand
- Forward
- [Isoform PDE4B5]: Cytoplasm . Cell membrane .
- Cytosol
- Golgi apparatus
Publication evidence
- PubMed 17519386
- Tissue specificity (tau)
- 0.706628
- Expression inequality (Gini)
- 0.369847
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)
- 26.68
- Brain - Nucleus accumbens (basal ganglia)
- 16.35
- Brain - Substantia nigra
- 15.75
- Brain - Frontal Cortex (BA9)
- 15.58
- Brain - Hypothalamus
- 14.88
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)26.68
- Brain - Nucleus accumbens (basal ganglia)16.35
- Brain - Substantia nigra15.75
- Brain - Frontal Cortex (BA9)15.58
- Brain - Hypothalamus14.88
- Brain - Caudate (basal ganglia)14.81
- Spleen14.8
- Brain - Cortex14.68
- Lung13.81
- Brain - Hippocampus13.8
- Brain - Amygdala13.72
- Brain - Putamen (basal ganglia)13.48
- Cells - EBV-transformed lymphocytes13.21
- Brain - Cerebellum12.7
- Adipose - Subcutaneous12.27
- Breast - Mammary Tissue12.1
- Artery - Tibial11.96
- Prostate11.72
- Brain - Cerebellar Hemisphere10.71
- Brain - Anterior cingulate cortex (BA24)10.71
- Adipose - Visceral (Omentum)10.48
- Minor Salivary Gland8.9
- Heart - Atrial Appendage8.78
- Small Intestine - Terminal Ileum8.02
- Artery - Aorta7.96
And 29 more, listed on the interactive page.
- GO:0032729
- GO:0032743
- GO:0050852
- GO:0005737
- GO:0005829
- GO:0005886
- GO:0004115
- GO:0005515
- GO:0030552
Related records
Trials (771)
- "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
- "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
- [18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
- A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
- A 20-Week Study Assessing the Efficacy of Apremilast in Patients with EB Simplex Generalized
- A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD
- A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis
- A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR)
- A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS)
- A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore:
- A Clinical Study of Oglemilast in Patients With Mild to Moderate Persistent Asthma
- A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma
- A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis
- A Comparison Study Between Adolescents With Asthma and Adults With Asthma on How They Absorb, Metabolise and Eliminate CHF 6001
- A Dose-finding and Confirmatory Trial of OPC-6535 in Patients With Active Crohn's Disease
- A Dose-finding Study of OPC-6535 in Patients With Active Crohn's Disease
- A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis
- A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer
- A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast
- A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis
Drugs (31)
- Aminophylline Phosphodiesterase 4 inhibitor
- Amlexanox Phosphodiesterase 4 inhibitor
- Apremilast Phosphodiesterase 4 inhibitor
- Cilomilast Phosphodiesterase 4 inhibitor
- Crisaborole Phosphodiesterase 4 inhibitor
- Difamilast Phosphodiesterase 4 inhibitor
- Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor
- Dovramilast Phosphodiesterase 4 inhibitor
- Drotaverine Phosphodiesterase 4 inhibitor
- Dyphylline Phosphodiesterase 4 inhibitor
- Ensifentrine Phosphodiesterase 4 inhibitor
- Flavoxate Phosphodiesterase 4 inhibitor
- Flavoxate hydrochloride Phosphodiesterase 4 inhibitor
- GSK-256066 Phosphodiesterase 4 inhibitor
- HT-0712 Phosphodiesterase 4 inhibitor
- Ibudilast Phosphodiesterase 4 inhibitor
- Lotamilast Phosphodiesterase 4 inhibitor
- MK-0873 Phosphodiesterase 4 inhibitor
- Oglemilast Phosphodiesterase 4 inhibitor
- Oxtriphylline Phosphodiesterase 4 inhibitor