> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde4a-87feb033-2b08-53fe-aafd-3f3b8635a7f8 > Record changed: 2026-10-13 # PDE4A ENSG00000065989 Target class Enzyme Chromosome 19 Approved drugs 14 Clinical candidates (approved and in development) 28 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 28 ## Druggability **Chemical probe available** Yes ## Names **Target name** PDE4A **Gene name** Phosphodiesterase 4A **Gene symbol** PDE4A **Previous gene symbols** - DPDE2 **Protein name** 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 32.62 **Tissue specificity (Gini)** 0.315 **Tissue specificity (tau)** 0.603 ## Pathways and interactions **KEGG gene identifiers** - hsa:5141 **Protein interaction confidence** 0.848725 **Protein interaction partners** 40 ### Reactome pathways (2) - R-HSA-180024 - R-HSA-418555 ## Genomic location **End position** 10469630 **Start position** 10416773 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000065989 **HGNC ID** HGNC:8780 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8780) **NCBI Gene ID** 5141 **UniProt ID** P27815 ## Cellular location - \[Isoform 1\]: Cytoplasm, perinuclear region . - SUBCELLULAR LOCATION: \[Isoform 2\]: Cytoplasm, perinuclear region . Cell projection, ruffle membrane . - SUBCELLULAR LOCATION: \[Isoform 3\]: Cytoplasm, cytosol . - SUBCELLULAR LOCATION: \[Isoform 4\]: Membrane - Peripheral membrane protein . Note=Isoform 4 has propensity for association with membranes. . - SUBCELLULAR LOCATION: \[Isoform 6\]: Cytoplasm, perinuclear region . - SUBCELLULAR LOCATION: \[Isoform 7\]: Cytoplasm, cytosol. Membrane - Peripheral membrane protein . Note=Predominantly cytosolic. . - Plasma membrane ### Publication evidence (5) - PubMed 15738310 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15738310/) - PubMed 7888306 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7888306/) - PubMed 9677330 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9677330/) - PubMed 11306681 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11306681/) - PubMed 18095939 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18095939/) ## Tissue expression **Tissue specificity (tau)** 0.602923 **Expression inequality (Gini)** 0.31468 ### Highest expression Expression in transcripts per million **Testis** 32.62 **Brain - Cerebellar Hemisphere** 29.75 **Brain - Cerebellum** 29.59 **Brain - Frontal Cortex (BA9)** 29.48 **Brain - Cortex** 27.51 ### All tissues (54) Expression in transcripts per million - Testis32.62 - Brain - Cerebellar Hemisphere29.75 - Brain - Cerebellum29.59 - Brain - Frontal Cortex (BA9)29.48 - Brain - Cortex27.51 - Cervix - Endocervix26.01 - Lung21.83 - Artery - Aorta21.52 - Brain - Anterior cingulate cortex (BA24)21.31 - Adipose - Subcutaneous20.81 - Thyroid20.41 - Cervix - Ectocervix19.65 - Cells - Cultured fibroblasts16.43 - Colon - Sigmoid16.17 - Uterus15.82 - Brain - Nucleus accumbens (basal ganglia)15.76 - Cells - EBV-transformed lymphocytes15.56 - Adipose - Visceral (Omentum)15.15 - Breast - Mammary Tissue14.34 - Fallopian Tube14.29 - Artery - Coronary14.06 - Bladder14.04 - Stomach13.7 - Prostate13.56 - Minor Salivary Gland13.18 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) ### Cellular components (4) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) ### Molecular functions (3) - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030552 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030552) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hPDE4A1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hPDE4A1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (771) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A 20-Week Study Assessing the Efficacy of Apremilast in Patients with EB Simplex Generalized - A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD - A 5-way Treatment Period Trial of Single Doses of Intranasal GSK256066 in Patients With Rhinitis - A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore: - A Clinical Study of Oglemilast in Patients With Mild to Moderate Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Chronic Persistent Asthma - A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis - A Comparison Study Between Adolescents With Asthma and Adults With Asthma on How They Absorb, Metabolise and Eliminate CHF 6001 - A Dose-finding and Confirmatory Trial of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Crohn's Disease - A Dose-finding Study of OPC-6535 in Patients With Active Ulcerative Colitis - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast - A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis ### Drugs (31) - Aminophylline Phosphodiesterase 4 inhibitor - Amlexanox Phosphodiesterase 4 inhibitor - [Apremilast](https://trialight.com/data/asset/apremilast-41723353-24b2-46d5-82cf-9e6280b6f765.md) Phosphodiesterase 4 inhibitor - Cilomilast Phosphodiesterase 4 inhibitor - Crisaborole Phosphodiesterase 4 inhibitor - Difamilast Phosphodiesterase 4 inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Dovramilast Phosphodiesterase 4 inhibitor - Drotaverine Phosphodiesterase 4 inhibitor - Dyphylline Phosphodiesterase 4 inhibitor - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) Phosphodiesterase 4 inhibitor - Flavoxate Phosphodiesterase 4 inhibitor - Flavoxate hydrochloride Phosphodiesterase 4 inhibitor - GSK-256066 Phosphodiesterase 4 inhibitor - HT-0712 Phosphodiesterase 4 inhibitor - Ibudilast Phosphodiesterase 4 inhibitor - Lotamilast Phosphodiesterase 4 inhibitor - MK-0873 Phosphodiesterase 4 inhibitor - Oglemilast Phosphodiesterase 4 inhibitor - Oxtriphylline Phosphodiesterase 4 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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