> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde3b-5f87b701-b20d-57d4-a93d-10606ebc9f47 > Record changed: 2026-10-13 # PDE3B ENSG00000152270 Target class Enzyme Chromosome 11 Approved drugs 8 Clinical candidates (approved and in development) 11 ## Clinical evidence **Approved drugs** 8 **Clinical candidates (approved and in development)** 11 ## Druggability **Chemical probe available** No ## Names **Other names** - HcGIP1 **Target name** PDE3B **Gene name** Phosphodiesterase 3B **Gene symbol** PDE3B **Protein name** cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 34 **Protein localisation evidence grade** Approved **Highest tissue expression** 25.65 **Tissue specificity (Gini)** 0.591 **Tissue specificity (tau)** 0.872 ## Pathways and interactions **KEGG gene identifiers** - hsa:5140 **Protein interaction confidence** 0.801404 **Protein interaction partners** 57 ### Reactome pathways (2) - R-HSA-165160 - R-HSA-418555 ## Genomic location **End position** 14874614 **Start position** 14643663 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000152270 **HGNC ID** HGNC:8779 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8779) **NCBI Gene ID** 5140 **UniProt ID** Q13370 ## Cellular location - Membrane - Multi-pass membrane protein . - Endoplasmic reticulum ## Tissue expression **Tissue specificity (tau)** 0.871691 **Expression inequality (Gini)** 0.591275 ### Highest expression Expression in transcripts per million **Colon - Sigmoid** 25.65 **Adipose - Subcutaneous** 17.01 **Brain - Cerebellar Hemisphere** 12.35 **Brain - Cerebellum** 11.72 **Adipose - Visceral (Omentum)** 10.89 ### All tissues (54) Expression in transcripts per million - Colon - Sigmoid25.65 - Adipose - Subcutaneous17.01 - Brain - Cerebellar Hemisphere12.35 - Brain - Cerebellum11.72 - Adipose - Visceral (Omentum)10.89 - Colon - Transverse10.32 - Bladder9.65 - Lung8.76 - Testis7.63 - Artery - Aorta5.86 - Liver5.56 - Breast - Mammary Tissue5.53 - Prostate5.05 - Esophagus - Muscularis5.01 - Small Intestine - Terminal Ileum4.71 - Spleen4.7 - Pituitary4.65 - Minor Salivary Gland3.45 - Whole Blood3.44 - Esophagus - Gastroesophageal Junction3.35 - Pancreas2.72 - Heart - Atrial Appendage2.16 - Artery - Coronary2.14 - Cells - EBV-transformed lymphocytes2.01 - Vagina1.8 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007162 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007162) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0016525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016525) - GO:0033629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033629) - GO:0050995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050995) - GO:0106072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106072) ### Cellular components (3) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0032045 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032045) ### Molecular functions (3) - GO:0004114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004114) - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## On-target safety - thrombocytopenia ### Effects - Inhibition/Decrease/Downregulation: chronic ### Studies - clinical: thrombocytopenia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased mortality in heart failure patients ### Effects - Inhibition/Decrease/Downregulation: chronic ### Studies - clinical: increased mortality in heart failure patients ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - tachycardia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: tachycardia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hypotension ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - ventricular arrhythmias ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: ventricular arrhythmias ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Related records ### Trials (455) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD - A Phase 3 Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD - A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline - [A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis](https://trialight.com/data/trial/a-phase-ii-study-of-ensifentrine-in-non-cystic-fibrosis-2fab3023-2a61-42c9-bc42-81128d34ce1d.md) - A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease - A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis - [A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD](https://trialight.com/data/trial/a-phase-iib-ensifentrine-glycopyrrolate-fixed-dose-68c4fb00-2224-4d79-9d35-630b485f5802.md) - A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics - A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial - A Safety Study of Pentoxifylline for the Treatment of Anemia - A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole - A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients - A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders - A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006) - A Study of LY2216684 and Theophylline in Healthy Subjects ### Drugs (14) - Aminophylline Phosphodiesterase 3 inhibitor - Anagrelide Phosphodiesterase 3 inhibitor - Anagrelide hydrochloride Phosphodiesterase 3 inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Enoximone Phosphodiesterase 3 inhibitor - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) Phosphodiesterase 3 inhibitor - K-134 Phosphodiesterase 3 inhibitor - Levosimendan Phosphodiesterase 3 inhibitor - Oxtriphylline Phosphodiesterase 3 inhibitor - Pentoxifylline 3',5'-cyclic phosphodiesterase inhibitor - Theophylline Phosphodiesterase 3 inhibitor - Theophylline anhydrous Phosphodiesterase 3 inhibitor - Theophylline glycinate Phosphodiesterase 3 inhibitor - Theophylline sodium glycinate Phosphodiesterase 3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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