> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde3a-40ed073a-fe23-530b-b4f0-57a94e07ca65 > Record changed: 2026-10-13 # PDE3A ENSG00000172572 Target class Enzyme Chromosome 12 Approved drugs 13 Clinical candidates (approved and in development) 16 ## Clinical evidence **Approved drugs** 13 **Clinical candidates (approved and in development)** 16 ## Druggability **Chemical probe available** No ## Names **Other names** - CGI-PDE **Target name** PDE3A **Gene name** Phosphodiesterase 3A **Gene symbol** PDE3A **Protein name** cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 46 **Protein localisation evidence grade** Approved **Highest tissue expression** 66.06 **Tissue specificity (Gini)** 0.649 **Tissue specificity (tau)** 0.869 ## Pathways and interactions **KEGG gene identifiers** - hsa:5139 **Reactome pathways** - R-HSA-418555 **Protein interaction confidence** 0.848472 **Protein interaction partners** 36 ## Genomic location **End position** 20688583 **Start position** 20368537 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000172572 **HGNC ID** HGNC:8778 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8778) **NCBI Gene ID** 5139 **UniProt ID** Q14432 ## Cellular location - Membrane - Multi-pass membrane protein . Cytoplasm, cytosol . - Plasma membrane ### Publication evidence - PubMed 35104454 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35104454/) ## Tissue expression **Tissue specificity (tau)** 0.869338 **Expression inequality (Gini)** 0.648573 ### Highest expression Expression in transcripts per million **Artery - Tibial** 66.06 **Artery - Aorta** 47.53 **Artery - Coronary** 46.65 **Esophagus - Gastroesophageal Junction** 37.45 **Esophagus - Muscularis** 34.51 ### All tissues (54) Expression in transcripts per million - Artery - Tibial66.06 - Artery - Aorta47.53 - Artery - Coronary46.65 - Esophagus - Gastroesophageal Junction37.45 - Esophagus - Muscularis34.51 - Heart - Left Ventricle30.72 - Colon - Sigmoid28.24 - Heart - Atrial Appendage22.78 - Colon - Transverse22.65 - Cervix - Endocervix18.3 - Small Intestine - Terminal Ileum14.89 - Adipose - Subcutaneous11.92 - Cervix - Ectocervix11.02 - Uterus9.66 - Fallopian Tube9.09 - Adipose - Visceral (Omentum)8.88 - Nerve - Tibial8.39 - Lung7.44 - Breast - Mammary Tissue6.84 - Prostate6.33 - Ovary6.22 - Thyroid6.2 - Brain - Cerebellar Hemisphere5.89 - Brain - Cerebellum5.45 - Pancreas4.38 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006629) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0043116 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043116) - GO:0043117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043117) - GO:0060700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060700) - GO:0071321 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071321) - GO:0071560 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071560) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) - GO:0106072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106072) ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (7) - GO:0004114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004114) - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) - GO:0004119 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004119) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030284) - GO:0047555 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047555) - GO:0099130 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099130) ## On-target safety - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - thrombocytopenia ### Effects - Inhibition/Decrease/Downregulation: chronic ### Studies - clinical: thrombocytopenia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased heart rate ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased heart rate ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - ventricular arrhythmia ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: ventricular arrhythmia ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - tachycardia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: tachycardia ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased platelet aggregation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased platelet aggregation ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hypotension ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - ventricular arrhythmias ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: ventricular arrhythmias ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased platelets ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased platelets ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased mortality in heart failure patients ### Effects - Inhibition/Decrease/Downregulation: chronic ### Studies - clinical: increased mortality in heart failure patients ### Biological samples - cardiovascular system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased cardiac contractility ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased cardiac contractility ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased female fertility ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased female fertility ### Biological samples (2) - cardiovascular - blood PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - thrombocytopaenia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: thrombocytopaenia ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - ventricular arrhythmia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: ventricular arrhythmia ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased heart rate ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased heart rate ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased cardiac contractility ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased cardiac contractility ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased blood pressure ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (649) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator - A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS) - A Clinical Study on Levosimendan Improvement of Prognosis of ARDS Patients by Optimizing Pulmonary Hemodynamics - A Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol in Combination on Patients With Diabetic Nephropathy - A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer - A Mono-center Study in Healthy Volunteers on the Comparative Bioavailability of Pletal 100 mg Tablets and a New Pletal 100 mg Orodispersible Tablet (ODT), This Latter in Fasting Conditions With and Without Water and Under Fed Conditions - A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD - A Phase 3 Trial to Evaluate the Safety and Efficacy of Ensifentrine in Patients With COPD - A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline - [A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis](https://trialight.com/data/trial/a-phase-ii-study-of-ensifentrine-in-non-cystic-fibrosis-2fab3023-2a61-42c9-bc42-81128d34ce1d.md) - A Phase II Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Single Inhaled Doses of Ensifentrine-glycopyrrolate Fixed Dose Combination, Ensifentrine, and Glycopyrrolate in Subjects With Chronic Obstructive Pulmonary Disease - A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis - [A Phase IIb Ensifentrine-glycopyrrolate Fixed-dose Combination Dose Ranging Study in Subjects With COPD](https://trialight.com/data/trial/a-phase-iib-ensifentrine-glycopyrrolate-fixed-dose-68c4fb00-2224-4d79-9d35-630b485f5802.md) - A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics - A Pilot Study to Determine the Feasibility and Utility of Implementing of the Full Scale TOM Trial - A Safety Study of Pentoxifylline for the Treatment of Anemia - A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole - A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients ### Drugs (21) - Aminophylline Phosphodiesterase 3 inhibitor - Anagrelide Phosphodiesterase 3 inhibitor - Anagrelide hydrochloride Phosphodiesterase 3 inhibitor - Cilostazol Phosphodiesterase 3A inhibitor - Dipyridamole 3',5'-cyclic phosphodiesterase inhibitor - Dyphylline Phosphodiesterase 3A inhibitor - Enoximone Phosphodiesterase 3 inhibitor - [Ensifentrine](https://trialight.com/data/asset/ensifentrine-0ba755a4-e4b3-4f85-bafa-abd450e78bd9.md) Phosphodiesterase 3 inhibitor - Ibudilast Phosphodiesterase 3A inhibitor - Inamrinone Phosphodiesterase 3A inhibitor - Inamrinone lactate Phosphodiesterase 3A inhibitor - K-134 Phosphodiesterase 3 inhibitor - Levosimendan Phosphodiesterase 3 inhibitor - Milrinone Phosphodiesterase 3A inhibitor - Milrinone lactate Phosphodiesterase 3A inhibitor - Oxtriphylline Phosphodiesterase 3 inhibitor - Pentoxifylline 3',5'-cyclic phosphodiesterase inhibitor - Theophylline Phosphodiesterase 3 inhibitor - Theophylline anhydrous Phosphodiesterase 3 inhibitor - Theophylline glycinate Phosphodiesterase 3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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