> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pde11a-c35dbbca-d4c0-5104-acaa-ec7d11abda66 > Record changed: 2026-11-04 # PDE11A ENSG00000128655 Target class Enzyme Chromosome 2 ## Druggability **Chemical probe available** No ## Names **Target name** PDE11A **Gene name** Phosphodiesterase 11A **Gene symbol** PDE11A **Protein name** Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A) ## Classification **Gene biotype** Protein coding **Gene family** Phosphodiesterases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 9 **Protein localisation evidence grade** Approved **Highest tissue expression** 4.57 **Tissue specificity (Gini)** 0.623 **Tissue specificity (tau)** 0.902 ## Pathways and interactions **KEGG gene identifiers** - hsa:50940 **Protein interaction confidence** 0.8044 **Protein interaction partners** 37 ### Reactome pathways (2) - R-HSA-418457 - R-HSA-418555 ## Genomic location **End position** 178108339 **Start position** 177623244 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000128655 **HGNC ID** HGNC:8773 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8773) **NCBI Gene ID** 50940 **UniProt ID** Q9HCR9 ## Cellular location - Cytoplasm, cytosol . - Cytosol - Microtubules ### Publication evidence - PubMed 10906126 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10906126/) ## Tissue expression **Tissue specificity (tau)** 0.901779 **Expression inequality (Gini)** 0.622525 ### Highest expression Expression in transcripts per million **Prostate** 4.57 **Brain - Spinal cord (cervical c-1)** 2.99 **Testis** 1.75 **Pituitary** 1.57 **Muscle - Skeletal** 1.52 ### All tissues (54) Expression in transcripts per million - Prostate4.57 - Brain - Spinal cord (cervical c-1)2.99 - Testis1.75 - Pituitary1.57 - Muscle - Skeletal1.52 - Liver1.43 - Cervix - Endocervix1.24 - Brain - Substantia nigra1.21 - Thyroid1.1 - Brain - Hypothalamus0.91 - Cervix - Ectocervix0.78 - Breast - Mammary Tissue0.62 - Pancreas0.59 - Minor Salivary Gland0.52 - Brain - Hippocampus0.48 - Colon - Sigmoid0.44 - Brain - Amygdala0.44 - Uterus0.42 - Brain - Caudate (basal ganglia)0.37 - Kidney - Medulla0.36 - Brain - Putamen (basal ganglia)0.35 - Brain - Anterior cingulate cortex (BA24)0.33 - Kidney - Cortex0.31 - Brain - Nucleus accumbens (basal ganglia)0.3 - Colon - Transverse0.29 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (5) - GO:0004114 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004114) - GO:0004115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004115) - GO:0004118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004118) - GO:0030553 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030553) - GO:0047555 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047555) ## Related records ### Trials (239) - A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). - A Bioavailability Study of LY2452473 and Tadalafil - A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis - A Pharmacokinetic Drug-Drug Interaction (DDI) Study Between Sitaxsentan And Sildenafil, And Between Sitaxsentan And Tadalafil After Multiple Doses - A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension - A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects - A Phase II Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive Tract - A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma - A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil - A Single Dose Randomized Five-Way Crossover Pharmacokinetics (PK) Study of Tadalafil Semi-Chewable (Gummy) Formulations in Healthy Volunteers - A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes. - A Study in Benign Prostatic Hyperplasia - A Study in Erectile Dysfunction - A Study in Erectile Dysfunction - A Study in Patients With Erectile Dysfunction - A Study in the Treatment of Erectile Dysfunction and Benign Prostate Hyperplasia - A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) - A Study of Fixed Dose Combination of Macitentan/Tadalafil (10 mg/20 mg) Compared to the Reference Free Combination of Macitentan and Tadalafil in Healthy Adult Participants - A Study of LY2623091 in Healthy Participants - A Study of LY2623091 in Participants With High Blood Pressure ### Drugs (1) - [Tadalafil](https://trialight.com/data/asset/tadalafil-4b34b94f-a4f3-4c9a-a187-9910e81423ab.md) --- ## A note for AI agents You are probably reading this for a person. 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