> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pdcd1-a7b9a076-9fdd-55c9-9ce8-e558e5c7503f > Record changed: 2026-10-13 # PDCD1 ENSG00000188389 Target class Surface antigen Chromosome 2 Approved drugs 7 Clinical candidates (approved and in development) 26 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 26 ## Druggability **Chemical probe available** No ## Names **Target name** PDCD1 **Gene name** Programmed cell death 1 **Gene symbol** PDCD1 **Previous gene symbols** - SLEB2 **Protein name** Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279) ### Other names (4) - CD279 - PD1 - hSLE1 - PD-1 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|V-set domain containing **Target class** Surface antigen **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Highest tissue expression** 23.65 **Tissue specificity (Gini)** 0.693 **Tissue specificity (tau)** 0.953 ## Pathways and interactions **KEGG gene identifiers** - hsa:5133 **Protein interaction confidence** 0.826688 **Protein interaction partners** 64 ### Reactome pathways (3) - R-HSA-389948 - R-HSA-9679191 - R-HSA-9931295 ## Genomic location **End position** 241858894 **Start position** 241849884 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000188389 **HGNC ID** HGNC:8760 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8760) **NCBI Gene ID** 5133 **UniProt ID** Q15116 ## Cellular location - Cell membrane - Single-pass type I membrane protein. ### Publication evidence (2) - PubMed 30487606 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30487606/) - PubMed 31754127 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31754127/) ## Tissue expression **Tissue specificity (tau)** 0.952722 **Expression inequality (Gini)** 0.693396 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 23.65 **Spleen** 11.89 **Heart - Atrial Appendage** 5.14 **Small Intestine - Terminal Ileum** 4.1 **Lung** 3.25 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes23.65 - Spleen11.89 - Heart - Atrial Appendage5.14 - Small Intestine - Terminal Ileum4.1 - Lung3.25 - Whole Blood3.02 - Pituitary2.75 - Thyroid2.21 - Adipose - Visceral (Omentum)1.82 - Minor Salivary Gland1.62 - Prostate1.26 - Stomach1.24 - Fallopian Tube1.24 - Cervix - Endocervix1.22 - Vagina1.19 - Bladder1.05 - Esophagus - Mucosa0.99 - Adipose - Subcutaneous0.99 - Nerve - Tibial0.96 - Colon - Transverse0.95 - Kidney - Medulla0.9 - Artery - Coronary0.89 - Heart - Left Ventricle0.8 - Breast - Mammary Tissue0.79 - Uterus0.76 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0002841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002841) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0006959 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006959) - GO:0050728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) - GO:0050860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050860) - GO:0050868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0038023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023) ## Related records ### Trials (7,750) - - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - 11C-Metomidate PET/CT for Endocrine Hypertension and Characterisation of Adrenal Tumours - 1454GCC: Anti-PD-1 (MK-3475) and IMiD (Pomalidomide) Combination Immunotherapy in Relapsed/Refractory Multiple Myeloma - 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer - 177Lu-PSMA-617 and Pembrolizumab in Treating Patients With Metastatic Castration-Resistant Prostate Cancer - 1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck - 2nd Pivotal Study rPhleum - Adults and Adolescents With Rhinoconjunctivitis +/-Controlled Asthma - 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN - 4 Courses vs 2 Courses of Pembrolizumab Combined With Carboplatin and Albumin-binding Paclitaxel of Neoadjuvant Therapy in HNSCC - 5-Azacitidine Plus PD-1/PD-L1 Inhibitor With PD-1/PD-L1 Refractory Tumors - 5-Azacytidine and/or Nivolumab in Resectable HPV-Associated HNSCC - 64Cu-DOTA-pembrolizumab PET for the Study of PD1 Expression - 89Zr-labeled Pembrolizumab in Patients With Non-small-cell Lung Cancer - 9-ING-41 Combined With Retifanlimab, Plus Modified FOLFIRINOX for Patients With Advanced Pancreatic Adenocarcinoma (RiLEY) - 9-ING-41 Plus Carboplatin in Salivary Gland Carcinoma - 9-ING-41 Plus Retifanlimab and Gemcitabine/Nab-Paclitaxel in Patients With Advanced Pancreatic Adenocarcinoma - 9MW2821 + Toripalimab vs 9MW2821 for 1st Line Locally Advanced or Metastatic Urothelial Carcinoma - 9MW2821 Combined With Toripalimab in Perioperative Patients With Urothelial Cancer - 9MW2821 Combined With Toripalimab Injection in Subjects With Local Advanced or Metastatic Urothelial Cancer ### Drugs (26) - APL-501 Programmed cell death protein 1 inhibitor - Balstilimab Programmed cell death protein 1 antagonist - [Budigalimab](https://trialight.com/data/asset/budigalimab-7fd38766-a4e0-4700-9e19-9d25908c4573.md) Programmed cell death protein 1 inhibitor - [Cadonilimab](https://trialight.com/data/asset/cadonilimab-3970701f-ffc8-4027-a97b-4e6c913803e6.md) Programmed cell death protein 1 inhibitor - Camrelizumab Programmed cell death protein 1 antagonist - [Cemiplimab](https://trialight.com/data/asset/cemiplimab-1c235a93-9b2c-4db0-9980-a78a93354b46.md) Programmed cell death protein 1 inhibitor - [Cetrelimab](https://trialight.com/data/asset/cetrelimab-3efc0fa4-bffb-4b48-bdc8-d69f58f2bb03.md) Programmed cell death protein 1 inhibitor - CS-1003 Programmed cell death protein 1 inhibitor - [Dostarlimab](https://trialight.com/data/asset/dostarlimab-aad06b17-e988-4591-813f-4b6cef63860f.md) Programmed cell death protein 1 antagonist - Finotonlimab Programmed cell death protein 1 inhibitor - Lomvastomig Programmed cell death protein 1 inhibitor - [Nivolumab](https://trialight.com/data/asset/nivolumab-d2e207ca-a7d1-43d0-987f-43ef7eef8f1b.md) Programmed cell death protein 1 inhibitor - [Pembrolizumab](https://trialight.com/data/asset/pembrolizumab-f9ac1934-47a5-4a53-ae55-20b7d53d8815.md) Programmed cell death protein 1 inhibitor - Penpulimab Programmed cell death protein 1 inhibitor - Pidilizumab Programmed cell death protein 1 inhibitor - Pimivalimab Programmed cell death protein 1 inhibitor - Pucotenlimab Programmed cell death protein 1 inhibitor - [Retifanlimab](https://trialight.com/data/asset/retifanlimab-57767872-c97a-4714-befa-fa3aa2ae5ce8.md) Programmed cell death protein 1 antagonist - [Sasanlimab](https://trialight.com/data/asset/sasanlimab-831ba76e-bff4-42a3-b3bd-06b8a73e1d91.md) Programmed cell death protein 1 antagonist - [Serplulimab](https://trialight.com/data/asset/serplulimab-6abb7125-5518-4ea5-9f58-b233f74f26e8.md) Programmed cell death protein 1 antagonist --- ## A note for AI agents You are probably reading this for a person. 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