> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/pcsk9-8d1e28c2-2f47-5dc5-b51e-ccfdc60cfc75 > Record changed: 2026-10-13 # PCSK9 ENSG00000169174 Target class Enzyme Chromosome 1 Approved drugs 2 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** No ## Names **Target name** PCSK9 **Gene name** Proprotein convertase subtilisin/kexin type 9 **Gene symbol** PCSK9 **Previous gene symbols** - HCHOLA3 **Protein name** Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) ### Other names (2) - NARC-1 - FH3 ## Classification **Gene biotype** Protein coding **Gene family** Proprotein convertase subtilisin/kexin family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 13 **Highest tissue expression** 25.55 **Tissue specificity (Gini)** 0.857 **Tissue specificity (tau)** 0.944 ## Pathways and interactions **KEGG gene identifiers** - hsa:255738 **Protein interaction confidence** 0.81229 **Protein interaction partners** 31 ### Reactome pathways (4) - R-HSA-381426 - R-HSA-8866427 - R-HSA-8957275 - R-HSA-8964038 ## Genomic location **End position** 55064852 **Start position** 55039445 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000169174 **HGNC ID** HGNC:20001 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:20001) **NCBI Gene ID** 255738 **UniProt ID** Q8NBP7 ## Cellular location - Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein. Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation. ## Tissue expression **Tissue specificity (tau)** 0.943529 **Expression inequality (Gini)** 0.857301 ### Highest expression Expression in transcripts per million **Liver** 25.55 **Brain - Cerebellar Hemisphere** 23.5 **Brain - Cerebellum** 22.15 **Lung** 6.74 **Esophagus - Mucosa** 4.94 ### All tissues (54) Expression in transcripts per million - Liver25.55 - Brain - Cerebellar Hemisphere23.5 - Brain - Cerebellum22.15 - Lung6.74 - Esophagus - Mucosa4.94 - Small Intestine - Terminal Ileum2.89 - Pancreas2.68 - Nerve - Tibial1.82 - Colon - Transverse1.63 - Skin - Sun Exposed (Lower leg)1.49 - Vagina1.21 - Skin - Not Sun Exposed (Suprapubic)1.19 - Testis1.1 - Cells - Cultured fibroblasts0.54 - Stomach0.33 - Kidney - Medulla0.28 - Adipose - Visceral (Omentum)0.27 - Whole Blood0.25 - Brain - Nucleus accumbens (basal ganglia)0.22 - Spleen0.2 - Artery - Aorta0.2 - Fallopian Tube0.19 - Esophagus - Muscularis0.16 - Cervix - Ectocervix0.15 - Bladder0.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0001920 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001920) - GO:0002091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002091) - GO:0002092 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002092) - GO:0007041 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007041) - GO:0010989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010989) - GO:0016540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016540) - GO:0032802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032802) - GO:0032805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032805) - GO:0042632 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042632) - GO:0043525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043525) - GO:1903783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903783) - GO:1905601 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905601) ### Cellular components (16) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005770) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0031232 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031232) - GO:0036020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036020) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:1990666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990666) - GO:1990667 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990667) ### Molecular functions (10) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0004175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004175) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019871 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019871) - GO:0030547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030547) - GO:0034190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034190) - GO:0050750 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050750) - GO:0070326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070326) - GO:0141110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141110) ## Related records ### Trials (384) - A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia - A Clinical Study to Evaluate the Safety and Effectiveness of Inclisiran Sodium in Indian Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia - A Clinical Trial of TQH2929 Injection in Patients With Acute Flare-up of Generalized Pustular Psoriasis - A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis - A Multiple Dose Study of PF-04950615 (RN316) in Subjects on High Doses of Statins - A Multiple Dose Study Of PF-04950615 (RN316) In Subjects On Maximum Doses Of Statins - A Pharmacokinetic and Pharmacodynamic Study of PF-04950615 (RN316) in Subjects With Hypercholesterolemia - A Pharmacokinetic Study of JS002 in Healthy Subjects - A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C) - A Phase I Clinical Trial of Single Subcutaneous Injection or Intravenous Infusion of SHR-1139 Injection in Healthy Chinese Subjects and Multiple Subcutaneous Injections in Patients With Moderate-to-severe Plaque Psoriasis - A Phase II Study Bolstering Outcomes by Optimizing Immunotherapy Strategies With Evolocumab and Nivolumab in Patients With Metastatic Renal Cell Carcinoma (BOOST-RCC) - A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy. - A Randomized Pilot Study of Evolocumab Plus Nivolumab/Ipilimumab in Treatment-Naïve Patients With Metastatic NSCLC - A Randomized Study to Evaluate the Effect of an "Inclisiran First" Implementation Strategy Compared to Usual Care in Patients With Atherosclerotic Cardiovascular Disease and Elevated LDL-C Despite Receiving Maximally Tolerated Statin Therapy (VICTORION-INITIATE) - A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease - A Real World Study Evaluating the Long-Term Quality of Life of Tildrakizumab in Adult Patients With Psoriasis - A Research Study Looking at How NNC0385-0434 Tablets Work to Lower Blood Cholesterol in People With Heart Disease or a High Risk of Heart Disease - A Single Dose Escalation Study of PCSK9 Inhibitor (JS002) in Health Subjects - A Study Explore JS001+JS002 in Patients With Advanced Cancer - A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene ### Drugs (11) - [Alirocumab](https://trialight.com/data/asset/alirocumab-94bb5dc8-32f2-4ed6-a82e-b554472e2cd5.md) Subtilisin/kexin type 9 inhibitor - Bococizumab Subtilisin/kexin type 9 inhibitor - [Evolocumab](https://trialight.com/data/asset/evolocumab-ece543fe-0502-44c3-bef4-ec566503cced.md) Subtilisin/kexin type 9 inhibitor - Frovocimab Subtilisin/kexin type 9 inhibitor - Inclisiran PCSK9 mRNA RNAi inhibitor - [Inclisiran sodium](https://trialight.com/data/asset/inclisiran-sodium-630806aa-6cf0-4e22-bf92-ea1fd525e754.md) PCSK9 mRNA rnai inhibitor - Lerodalcibep Subtilisin/kexin type 9 inhibitor - Ongericimab Subtilisin/kexin type 9 inhibitor - Ralpancizumab Subtilisin/kexin type 9 inhibitor - RG-7652 Subtilisin/kexin type 9 inhibitor - [Tafolecimab](https://trialight.com/data/asset/tafolecimab-3a21b706-6c3c-432b-9995-85691431362d.md) Subtilisin/kexin type 9 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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