> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/parp3-d8123f64-d038-5fd1-9927-4abad8f9d28d > Record changed: 2026-10-13 # PARP3 ENSG00000041880 Target class Enzyme Chromosome 3 Approved drugs 3 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** PARP3 **Gene name** Poly(ADP-ribose) polymerase family member 3 **Gene symbol** PARP3 **Previous gene symbols** - ADPRTL3 **Protein name** Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly \[ADP-ribose\] polymerase 3) (PARP-3) (hPARP-3) (Poly\[ADP-ribose\] synthase 3) (pADPRT-3) ### Other names (5) - ADPRT3 - IRT1 - hPARP-3 - pADPRT-3 - ARTD3 ## Classification **Gene biotype** Protein coding **Gene family** Poly(ADP-ribose) polymerases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 50.46 **Tissue specificity (Gini)** 0.248 **Tissue specificity (tau)** 0.589 ## Pathways and interactions **KEGG gene identifiers** - hsa:10039 **Protein interaction confidence** 0.807357 **Protein interaction partners** 14 ## Genomic location **End position** 51948871 **Start position** 51942252 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000041880 **HGNC ID** HGNC:273 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:273) **NCBI Gene ID** 10039 **UniProt ID** Q9Y6F1 ## Cellular location - Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334, PubMed:28447610). Also localizes to single-strand breaks (PubMed:27530147). Preferentially localized to the daughter centriole (PubMed:10329013). . - Nuclear bodies - Nucleoplasm ### Publication evidence (5) - PubMed 16924674 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16924674/) - PubMed 21270334 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21270334/) - PubMed 27530147 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27530147/) - PubMed 28447610 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28447610/) - PubMed 10329013 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10329013/) ## Tissue expression **Tissue specificity (tau)** 0.589292 **Expression inequality (Gini)** 0.248047 ### Highest expression Expression in transcripts per million **Adrenal Gland** 50.46 **Thyroid** 47.18 **Cells - Cultured fibroblasts** 36.4 **Bladder** 33.32 **Colon - Sigmoid** 32.25 ### All tissues (54) Expression in transcripts per million - Adrenal Gland50.46 - Thyroid47.18 - Cells - Cultured fibroblasts36.4 - Bladder33.32 - Colon - Sigmoid32.25 - Nerve - Tibial32.16 - Small Intestine - Terminal Ileum31.47 - Cells - EBV-transformed lymphocytes30.99 - Breast - Mammary Tissue30.79 - Prostate30.37 - Esophagus - Muscularis30.07 - Spleen27.34 - Lung26.88 - Artery - Aorta26.48 - Adipose - Subcutaneous26.32 - Uterus26.17 - Esophagus - Gastroesophageal Junction25.71 - Adipose - Visceral (Omentum)25.26 - Artery - Coronary24.82 - Colon - Transverse24.8 - Cervix - Endocervix24.13 - Fallopian Tube23.87 - Kidney - Cortex23.8 - Vagina23 - Cervix - Ectocervix22.17 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (10) - GO:0000723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000723) - GO:0006302 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006302) - GO:0006303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006303) - GO:0030592 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030592) - GO:0032211 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032211) - GO:0060236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060236) - GO:0070212 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070212) - GO:0070213 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070213) - GO:1990166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990166) - GO:2001034 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001034) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) - GO:0016604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016604) - GO:0035861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035861) ### Molecular functions (8) - GO:0003824 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003824) - GO:0003950 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003950) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0140294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140294) - GO:0140804 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140804) - GO:0140806 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140806) - GO:0140807 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140807) - GO:1990404 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990404) ## Related records ### Trials (584) - 177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours - 177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant Prostate Cancer - A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer - A Clinical Study Conducted in Multiple Centers Comparing Veliparib in Combination With Carboplatin and Paclitaxel Versus a Placebo in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer - A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer - A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy - A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003) - [A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)](https://trialight.com/data/trial/a-clinical-study-of-sacituzumab-tirumotecan-sac-tmt-mk-2870-47421f86-889b-4c0b-a65c-14ed97707a1e.md) - A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer - A Crossover Bioequivalence Study of Olaparib Tablets, 150 mg (Lek Pharmaceuticals d.d.) and Lynparza® (Olaparib) Tablets 150 mg (AstraZeneca Pharmaceuticals LP), in Patients With Breast Cancer Gene (BRCA) Mutated Ovarian Cancer, Recurrent Ovarian Cancer or Metastatic Breast Cancer - A Dye for the Detection of Cancer of the Tongue and Mouth - A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors - A Phase 1 Study of Single Agent Veliparib in Japanese Subjects With Advanced Solid Tumors - [A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-xl309-ism3091-alone-and-in-combination-in-3b56b584-0baa-457a-a068-4ee9f6003f9d.md) - A Phase 2 Study of Cediranib in Combination With Olaparib in Advanced Solid Tumors - A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer - A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases - A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients - A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors - A Phase I, Open-Label, 2 Part Multicentre Study to Assess the Safety and Efficacy of Olaparib in Combination With Carboplatin in Patients With Advanced HER-2 Negative Breast Cancer ### Drugs (5) - E-7016 PARP 1, 2 and 3 inhibitor - [Olaparib](https://trialight.com/data/asset/olaparib-3421b73f-1a4f-4337-b6f3-de5feeb57108.md) PARP 1, 2 and 3 inhibitor - Rucaparib PARP 1, 2 and 3 inhibitor - Rucaparib camsylate PARP 1, 2 and 3 inhibitor - Veliparib PARP 1, 2 and 3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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