> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/parp2-2551f72f-f11f-5c9e-9253-3f01dfbad379 > Record changed: 2026-10-13 # PARP2 ENSG00000129484 Target class Enzyme Chromosome 14 Approved drugs 7 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Other names** - ARTD2 **Target name** PARP2 **Gene name** Poly(ADP-ribose) polymerase 2 **Gene symbol** PARP2 **Previous gene symbols** - ADPRTL2 **Protein name** Poly \[ADP-ribose\] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly\[ADP-ribose\] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) ## Classification **Gene biotype** Protein coding **Gene family** Poly(ADP-ribose) polymerases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 79.61 **Tissue specificity (Gini)** 0.259 **Tissue specificity (tau)** 0.68 ## Pathways and interactions **KEGG gene identifiers** - hsa:10038 **Protein interaction confidence** 0.839318 **Protein interaction partners** 44 ### Reactome pathways (5) - R-HSA-110362 - R-HSA-5685939 - R-HSA-5696394 - R-HSA-5696395 - R-HSA-5696400 ## Genomic location **End position** 20357905 **Start position** 20343601 **Chromosome** 14 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000129484 **HGNC ID** HGNC:272 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:272) **NCBI Gene ID** 10038 **UniProt ID** Q9UGN5 ## Cellular location - Nucleus . Chromosome . Note=Recruited to DNA damage sites in a PARP1-dependent process: recognizes and binds poly-ADP-ribose chains produced by PARP1 at DNA damage sites via its N-terminus, leading to its recruitment. . - Nucleoli - Nucleoplasm ### Publication evidence (7) - PubMed 10364231 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10364231/) - PubMed 26704974 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26704974/) - PubMed 30104678 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30104678/) - PubMed 30321391 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30321391/) - PubMed 32939087 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32939087/) - PubMed 33141820 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33141820/) - PubMed 35349716 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35349716/) ## Tissue expression **Tissue specificity (tau)** 0.679857 **Expression inequality (Gini)** 0.25888 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 79.61 **Brain - Cerebellum** 73.57 **Testis** 45.77 **Cells - EBV-transformed lymphocytes** 43.57 **Ovary** 43.36 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere79.61 - Brain - Cerebellum73.57 - Testis45.77 - Cells - EBV-transformed lymphocytes43.57 - Ovary43.36 - Nerve - Tibial42.56 - Uterus42.08 - Brain - Frontal Cortex (BA9)39.35 - Cervix - Endocervix38.22 - Pituitary36.76 - Brain - Cortex36.5 - Cervix - Ectocervix34.93 - Thyroid32.91 - Fallopian Tube31.68 - Colon - Sigmoid28.91 - Breast - Mammary Tissue28.26 - Adipose - Subcutaneous27.19 - Skin - Sun Exposed (Lower leg)26.94 - Vagina26.34 - Brain - Nucleus accumbens (basal ganglia)25.42 - Skin - Not Sun Exposed (Suprapubic)25.15 - Artery - Aorta25.02 - Artery - Tibial25 - Spleen24.95 - Esophagus - Gastroesophageal Junction24.71 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006281) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0030592 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030592) - GO:0070212 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070212) - GO:0070213 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070213) - GO:0140861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140861) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0090734 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090734) ### Molecular functions (12) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003684 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003684) - GO:0003950 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003950) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0031491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031491) - GO:0072572 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072572) - GO:0140294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140294) - GO:0140805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140805) - GO:0140806 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140806) - GO:0140807 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140807) - GO:0160004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160004) - GO:1990404 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990404) ## Related records ### Trials (940) - 177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours - 177Lu-PSMA-617 Therapy and Olaparib in Patients With Metastatic Castration Resistant Prostate Cancer - 177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer - A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors - A Bioequivalence Study to Compare Senaparib Manufactured at 2 Sites in Healthy Subjects in Fasting State - A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer - A Chinese Patent Medicine Yangzhengxiaoji Capsule to Improve the Nausea of Niraparib in the Maintenance Treatment in Ovarian Cancer - A Clinical Study Conducted in Multiple Centers Comparing Veliparib in Combination With Carboplatin and Paclitaxel Versus a Placebo in Combination With Carboplatin and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer - A Clinical Study Conducted in Multiple Centers Evaluating Escalating Doses of Veliparib in Combination With Capecitabine and Radiation in Patients With Locally Advanced Rectal Cancer - A Clinical Study Evaluating a Combination of Oregovomab and Niraparib in Adult Women With Platinum Sensitive Recurrent Ovarian Cancer. - A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy - A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003) - A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer - [A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)](https://trialight.com/data/trial/a-clinical-study-of-sacituzumab-tirumotecan-sac-tmt-mk-2870-47421f86-889b-4c0b-a65c-14ed97707a1e.md) - A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer - A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer - A Crossover Bioequivalence Study of Olaparib Tablets, 150 mg (Lek Pharmaceuticals d.d.) and Lynparza® (Olaparib) Tablets 150 mg (AstraZeneca Pharmaceuticals LP), in Patients With Breast Cancer Gene (BRCA) Mutated Ovarian Cancer, Recurrent Ovarian Cancer or Metastatic Breast Cancer - A Dose-escalation Study of the Safety and Pharmacology of DAN-222 in Subjects With Metastatic Breast Cancer - A Dye for the Detection of Cancer of the Tongue and Mouth - A Feasibility Study of Niraparib for Advanced, BRCA1-like, HER2-negative Breast Cancer Patients ### Drugs (12) - 2X-121 Poly \[ADP-ribose\] polymerase 2 inhibitor - E-7016 PARP 1, 2 and 3 inhibitor - Niraparib Poly \[ADP-ribose\] polymerase 2 inhibitor - Niraparib tosylate monohydrate Poly \[ADP-ribose\] polymerase 2 inhibitor - [Olaparib](https://trialight.com/data/asset/olaparib-3421b73f-1a4f-4337-b6f3-de5feeb57108.md) PARP 1, 2 and 3 inhibitor - Pamiparib Poly \[ADP-ribose\] polymerase 2 inhibitor - Rucaparib PARP 1, 2 and 3 inhibitor - Rucaparib camsylate PARP 1, 2 and 3 inhibitor - [Senaparib](https://trialight.com/data/asset/senaparib-5d728ab4-660f-428a-b890-bbc768e824c5.md) Poly \[ADP-ribose\] polymerase 2 inhibitor - Talazoparib Poly \[ADP-ribose\] polymerase 2 inhibitor - Talazoparib tosylate Poly \[ADP-ribose\] polymerase 2 inhibitor - Veliparib PARP 1, 2 and 3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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