> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/p2ry12-507204ab-bea0-5561-8a51-7e9409c2e44d > Record changed: 2026-11-04 # P2RY12 ENSG00000169313 Target class GPCR Chromosome 3 Approved drugs 10 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 10 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Target name** P2RY12 **Gene name** Purinergic receptor P2Y12 **Gene symbol** P2RY12 **Protein name** P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) ### Other names (3) - P2Y12 - SP1999 - HORK3 ## Classification **Gene biotype** Protein coding **Gene family** P2Y receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 27 **Highest tissue expression** 20.6 **Tissue specificity (Gini)** 0.644 **Tissue specificity (tau)** 0.891 ## Pathways and interactions **KEGG gene identifiers** - hsa:64805 **Protein interaction confidence** 0.802033 **Protein interaction partners** 30 ### Reactome pathways (3) - R-HSA-392170 - R-HSA-417957 - R-HSA-418594 ## Genomic location **End position** 151384753 **Start position** 151336843 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000169313 **HGNC ID** HGNC:18124 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18124) **NCBI Gene ID** 64805 **UniProt ID** Q9H244 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 11196645 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11196645/) - PubMed 12578987 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12578987/) - PubMed 24670650 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24670650/) - PubMed 24784220 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24784220/) ## Tissue expression **Tissue specificity (tau)** 0.890758 **Expression inequality (Gini)** 0.643533 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 20.6 **Brain - Substantia nigra** 12.82 **Nerve - Tibial** 9.35 **Brain - Amygdala** 8.71 **Brain - Hypothalamus** 8.06 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)20.6 - Brain - Substantia nigra12.82 - Nerve - Tibial9.35 - Brain - Amygdala8.71 - Brain - Hypothalamus8.06 - Brain - Caudate (basal ganglia)7.58 - Brain - Nucleus accumbens (basal ganglia)7.39 - Brain - Hippocampus6.97 - Brain - Frontal Cortex (BA9)6.83 - Brain - Anterior cingulate cortex (BA24)5.72 - Brain - Putamen (basal ganglia)5.05 - Spleen2.96 - Adipose - Subcutaneous2.86 - Brain - Cortex2.45 - Brain - Cerebellar Hemisphere2.15 - Adipose - Visceral (Omentum)2.14 - Colon - Sigmoid2.08 - Artery - Coronary1.96 - Small Intestine - Terminal Ileum1.86 - Lung1.73 - Breast - Mammary Tissue1.58 - Esophagus - Muscularis1.55 - Esophagus - Gastroesophageal Junction1.46 - Cervix - Endocervix1.42 - Brain - Cerebellum1.09 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0030168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168) - GO:0050920 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050920) - GO:0070527 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070527) - GO:1900029 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900029) - GO:1904141 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904141) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (2) - GO:0001621 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001621) - GO:0005085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005085) ## Related records ### Trials (968) - \[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES\] - 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease - 1-month DAPT Plus 5-month Ticagrelor Monotherapy Versus 12-month DAPT in Patients With Drug-coated Balloon - 24-month Ticagrelor-based Dual-antiplatelet Therapy Versus Clopidogrel-based Dual-antiplatelet theRapy aftEr 12 Months of DrUg-eluting Stent Implantation in High isChEmic Risk Patients: P-REDUCE Trial - 3 Months Versus 12 Months Dual Antiplatelet Therapy After Drug-eluting Stent Implantation in STEMI - 75 or 150 mg Clopidogrel Maintenance Doses Following PCI (ISAR-CHOICE-2) - A 30 Day Study to Evaluate Efficacy and Safety of Pre-hospital vs. In-hospital Initiation of Ticagrelor Therapy in STEMI Patients Planned for Percutaneous Coronary Intervention (PCI) - A Clinical Study of Safety and P2Y12 Receptor Inhibition Effects of Ticagrelor and Clopidogrel in Vietnamese Patient - A Clinical Study to Assess the Effect of Clopidogrel on the Pharmacokinetics of Selexipag and Its Active Metabolite in Healthy Male Subjects - A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX) - A Clinical Trial of Antiplatelets in Psoriasis - A Clinical Trial to Demonstrate the Efficacy of Cangrelor - A Comparative Study of Selatogrel (ACT-246475) Formulations in Healthy Subjects - A Comparison of Antiplatelet Therapies in Asian Subjects With Acute Coronary Syndrome - A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention - A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects - A Comparison of Prasugrel at PCI or Time of Diagnosis of Non-ST Elevation Myocardial Infarction - A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome - A Drug-drug Interaction Study of YZJ-1139 Tablets and Ticagrelor Tablets in Healthy Subjects - A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI) ### Drugs (19) - Adenosine diphosphate - Cangrelor Purinergic receptor P2Y12 antagonist; Purinergic receptor P2Y12 inhibitor - Cangrelor tetrasodium Purinergic receptor P2Y12 antagonist - [Clopidogrel](https://trialight.com/data/asset/clopidogrel-04b37672-3c33-4ef3-8654-ae1df3cc9842.md) Purinergic receptor P2Y12 antagonist - Clopidogrel besilate Purinergic receptor P2Y12 antagonist - Clopidogrel bisulfate Purinergic receptor P2Y12 antagonist - Clopidogrel hydrobromide Purinergic receptor P2Y12 antagonist - Clopidogrel hydrochloride Purinergic receptor P2Y12 antagonist - Elinogrel Purinergic receptor P2Y12 antagonist - Elinogrel potassium Purinergic receptor P2Y12 antagonist - Prasugrel Purinergic receptor P2Y12 antagonist - Prasugrel besylate Purinergic receptor P2Y12 antagonist - Prasugrel hydrochloride Purinergic receptor P2Y12 antagonist - Regrelor Purinergic receptor P2Y12 antagonist - Regrelor disodium Purinergic receptor P2Y12 antagonist - Selatogrel Purinergic receptor P2Y12 antagonist - Ticagrelor Purinergic receptor P2Y12 negative allosteric modulator - Ticlopidine Purinergic receptor P2Y12 antagonist - Ticlopidine hydrochloride Purinergic receptor P2Y12 antagonist --- ## A note for AI agents You are probably reading this for a person. 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