> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/p2rx7-756c9351-a304-5284-a58c-fdd4974efad3 > Record changed: 2026-10-13 # P2RX7 ENSG00000089041 Target class Ion channel Chromosome 12 Approved drugs 0 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Target name** P2RX7 **Gene name** Purinergic receptor P2X 7 **Gene symbol** P2RX7 **Protein name** P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) ### Other names (2) - P2X7 - MGC20089 ## Classification **Gene biotype** Protein coding **Gene family** Purinergic receptors P2X **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 48 **Highest tissue expression** 29.07 **Tissue specificity (Gini)** 0.455 **Tissue specificity (tau)** 0.78 ## Pathways and interactions **KEGG gene identifiers** - hsa:5027 **Protein interaction confidence** 0.852857 **Protein interaction partners** 21 ### Reactome pathways (5) - R-HSA-139853 - R-HSA-418346 - R-HSA-844456 - R-HSA-9660826 - R-HSA-9856532 ## Genomic location **End position** 121188032 **Start position** 121132819 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000089041 **HGNC ID** HGNC:8537 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8537) **NCBI Gene ID** 5027 **UniProt ID** Q99572 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 12107182 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12107182/) - PubMed 23303206 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23303206/) - PubMed 28326637 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28326637/) ## Tissue expression **Tissue specificity (tau)** 0.780186 **Expression inequality (Gini)** 0.455151 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 29.07 **Skin - Sun Exposed (Lower leg)** 19.19 **Cervix - Ectocervix** 16.41 **Skin - Not Sun Exposed (Suprapubic)** 16.33 **Nerve - Tibial** 16.25 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)29.07 - Skin - Sun Exposed (Lower leg)19.19 - Cervix - Ectocervix16.41 - Skin - Not Sun Exposed (Suprapubic)16.33 - Nerve - Tibial16.25 - Brain - Substantia nigra15.83 - Brain - Cerebellum13.76 - Brain - Hippocampus13.58 - Brain - Cortex13.56 - Ovary13.01 - Brain - Cerebellar Hemisphere12.34 - Lung11.39 - Brain - Frontal Cortex (BA9)10.98 - Cervix - Endocervix9.91 - Brain - Amygdala9.51 - Brain - Putamen (basal ganglia)8.5 - Vagina8.5 - Spleen8.36 - Brain - Hypothalamus8.23 - Brain - Caudate (basal ganglia)7.88 - Uterus7.34 - Brain - Anterior cingulate cortex (BA24)7.23 - Colon - Sigmoid6.47 - Cells - EBV-transformed lymphocytes5.73 - Fallopian Tube5.38 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0010524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010524) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0017121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017121) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0032060 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032060) - GO:0032731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032731) - GO:0033198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033198) - GO:0034767 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034767) - GO:0035590 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035590) - GO:0045794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045794) - GO:0045821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045821) - GO:0046931 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046931) - GO:0051899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051899) - GO:0070207 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070207) - GO:0071318 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071318) - GO:1904172 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904172) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (6) - GO:0001614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001614) - GO:0004931 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004931) - GO:0005267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267) - GO:0005272 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005272) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) ## On-target safety - increased urinary sodium excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urine excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased inflammation ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hemolysis ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: hemolysis ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - neurodegeneration ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: neurodegeneration ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (415) - 12-Week Trial Investigating L-carnitine Tartrate, Dihydrocapsiate and Protein Yeast Hydrolysate on Energy Intake and Expenditure in Overweight Adults - 14-C ADME (Absorption, Disposition, Metabolism and Excretion) Study in Man - 3-part Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EXS21546 - 5-Way Crossover Study to Compare the Safety, Tolerability and Pharmacokinetics of New Oral Cannabinoid Formulations Administered as Single Doses, With Buccal Sativex®, in Healthy Volunteers - A 28 Day Parallel Group Study to Assess the Effects of RDN-929 - [A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis](https://trialight.com/data/trial/a-3-part-study-of-syx-5219-in-healthy-volunteers-and-ad181b14-4ed6-4538-af9c-dfcb0bd8eab2.md) - A 6 Months Double Blind Trial to Prevent PONV in Laparoscopic Cholecystectomy - A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA) - A Bioequivalence Study of Sanchi-Tongshu Capsule (Enteric Coated Pellets) - A Clinical Study of Gulingji Capsule in the Treatment of Idiopathic Oligospermia, Asthenia, and Teratozoospermia - A Clinical Study of Treating Influenza With Liugan Shuangjie Heji - A Clinical Study of Xin'an Medicine in the Treatment of Bi Syndrome - A Clinical Study of Xin'an Medicine in the Treatment of Knee Osteoarthritis - A Clinical Study on Qianjin Capsule of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Damp-heat Stasis and Qi Deficiency Syndrome) - A Clinical Trial Evaluating TQF3250 Capsules in Healthy Adult Subjects - A Clinical Trial of CS12192 in Healthy Subjects - A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder - A Clinical Trial of KT07 Capsule in the U.S.A - A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors - A Clinical Trial of TQH3906 Capsules in Healthy Volunteers ### Drugs (4) - AZD9056 P2X purinoceptor 7 antagonist - CE-224535 P2X purinoceptor 7 antagonist - GSK1482160 P2X purinoceptor 7 negative allosteric modulator - [JNJ-54175446](https://trialight.com/data/asset/jnj-54175446-90c8b1c3-c968-4060-b6e3-dd906e14f466.md) P2X purinoceptor 7 antagonist --- ## A note for AI agents You are probably reading this for a person. 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