> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/p2rx4-1433800a-3e93-57de-a725-b66d2f5e236c > Record changed: 2026-11-04 # P2RX4 ENSG00000135124 Target class Ion channel Chromosome 12 ## Druggability **Chemical probe available** Yes ## Names **Other names** - P2X4 **Target name** P2RX4 **Gene name** Purinergic receptor P2X 4 **Gene symbol** P2RX4 **Protein name** P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor) ## Classification **Gene biotype** Protein coding **Gene family** Purinergic receptors P2X **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 75.3 **Tissue specificity (Gini)** 0.362 **Tissue specificity (tau)** 0.741 ## Pathways and interactions **KEGG gene identifiers** - hsa:5025 **Protein interaction confidence** 0.86355 **Protein interaction partners** 20 ### Reactome pathways (3) - R-HSA-139853 - R-HSA-418346 - R-HSA-9660826 ## Genomic location **End position** 121234112 **Start position** 121210065 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000135124 **HGNC ID** HGNC:8535 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8535) **NCBI Gene ID** 5025 **UniProt ID** Q99571 ## Cellular location - Cell membrane - Multi-pass membrane protein . Lysosome membrane - Multi-pass membrane protein . ### Publication evidence (4) - PubMed 10515189 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10515189/) - PubMed 23303206 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23303206/) - PubMed 28326637 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28326637/) - PubMed 24817123 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24817123/) ## Tissue expression **Tissue specificity (tau)** 0.741081 **Expression inequality (Gini)** 0.362053 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 75.3 **Brain - Cerebellum** 71.78 **Lung** 40.36 **Minor Salivary Gland** 38.2 **Colon - Transverse** 36.39 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere75.3 - Brain - Cerebellum71.78 - Lung40.36 - Minor Salivary Gland38.2 - Colon - Transverse36.39 - Spleen34.61 - Small Intestine - Terminal Ileum34.58 - Ovary34.54 - Cervix - Endocervix33.14 - Prostate29.34 - Pituitary28.98 - Cervix - Ectocervix28.01 - Fallopian Tube27.64 - Cells - EBV-transformed lymphocytes27.26 - Pancreas25.97 - Artery - Aorta25.15 - Stomach25.11 - Thyroid24.85 - Nerve - Tibial23.56 - Breast - Mammary Tissue23.37 - Bladder22.47 - Artery - Coronary21.91 - Adipose - Subcutaneous21.46 - Uterus21.4 - Whole Blood20.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008217 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008217) - GO:0010524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010524) - GO:0010614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010614) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0033198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033198) - GO:0034220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034220) - GO:0034405 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034405) - GO:0035590 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035590) - GO:0042118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042118) - GO:0043536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043536) - GO:0050850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050850) - GO:0051899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051899) - GO:0055117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055117) - GO:0055119 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055119) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:0071318 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071318) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) - GO:1904141 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904141) - GO:2001028 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001028) ### Cellular components (6) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0030054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030054) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (7) - GO:0001614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001614) - GO:0004931 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004931) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0099604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099604) ## On-target safety - increased urinary sodium excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urine excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased inflammation ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hemolysis ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: hemolysis ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - neurodegeneration ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: neurodegeneration ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (663) - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension - 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder - A Bioequivalence Study of Amlodipine / Valsartan From Amlodipine/Valsartan 10/160 Tablets (Pharmacare, Palestine) and Exforge Tablets (Novartis Pharma, USA) - A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan - A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan - A Bioequivalence Study of Valsartan / Amlodipine From Valsartan and Amlodipine Tablets (Hua Yuan Pharmaceutical LLC, China) and Valsartan and Amlodipine Tablets (Ⅰ) (Novartis Pharma Schweiz AG, Switzerland) - A Causal Role for Voltage-gated Cav1.2 Calcium Channels in Mediating 5G FR1 Effects on Sleep-associated Brain Health in Humans - A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure. - [A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors](https://trialight.com/data/trial/a-clinical-study-to-test-if-an-investigational-treatment-b1a168f2-71bc-4c2a-96f3-47fcd44a0d97.md) - A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Fimasartan and Amlodipine in Healthy Male Subjects - A Combination Therapy In Patients With Social Anxiety Disorder - A Comparative Study Between Amlodipine 10mg And 5mg With Hypertension For Whom 5mg Is Insufficient - A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study) - A Dose Selection Trial of CKD-330 in Patients With Essential Hypertension - A Drug Interaction Study of 31001074 and Paroxetine in Healthy Volunteers ### Drugs (4) - Adenosine triphosphate - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) - Nimodipine - [Paroxetine](https://trialight.com/data/asset/paroxetine-f0d98a38-4d49-47c7-88d7-1abba0fae55b.md) --- ## A note for AI agents You are probably reading this for a person. 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