P2RX4
ENSG00000135124
Target class
Ion channel
Chromosome
12
- Chemical probe available
- Yes
- Other names
- P2X4
- Target name
- P2RX4
- Gene name
- Purinergic receptor P2X 4
- Gene symbol
- P2RX4
- Protein name
- P2X purinoceptor 4 (P2X4) (ATP receptor) (Purinergic receptor)
- Gene biotype
- Protein coding
- Gene family
- Purinergic receptors P2X
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 54
- Highest tissue expression
- 75.3
- Tissue specificity (Gini)
- 0.362
- Tissue specificity (tau)
- 0.741
- KEGG gene identifiers
- hsa:5025
- Protein interaction confidence
- 0.86355
- Protein interaction partners
- 20
- R-HSA-139853
- R-HSA-418346
- R-HSA-9660826
- End position
- 121234112
- Start position
- 121210065
- Chromosome
- 12
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein . Lysosome membrane
- Multi-pass membrane protein .
- PubMed 10515189
- PubMed 23303206
- PubMed 28326637
- PubMed 24817123
- Tissue specificity (tau)
- 0.741081
- Expression inequality (Gini)
- 0.362053
Expression in transcripts per million
- Brain - Cerebellar Hemisphere
- 75.3
- Brain - Cerebellum
- 71.78
- Lung
- 40.36
- Minor Salivary Gland
- 38.2
- Colon - Transverse
- 36.39
Expression in transcripts per million
- Brain - Cerebellar Hemisphere75.3
- Brain - Cerebellum71.78
- Lung40.36
- Minor Salivary Gland38.2
- Colon - Transverse36.39
- Spleen34.61
- Small Intestine - Terminal Ileum34.58
- Ovary34.54
- Cervix - Endocervix33.14
- Prostate29.34
- Pituitary28.98
- Cervix - Ectocervix28.01
- Fallopian Tube27.64
- Cells - EBV-transformed lymphocytes27.26
- Pancreas25.97
- Artery - Aorta25.15
- Stomach25.11
- Thyroid24.85
- Nerve - Tibial23.56
- Breast - Mammary Tissue23.37
- Bladder22.47
- Artery - Coronary21.91
- Adipose - Subcutaneous21.46
- Uterus21.4
- Whole Blood20.01
And 29 more, listed on the interactive page.
- GO:0007165
- GO:0008217
- GO:0010524
- GO:0010614
- GO:0019722
- GO:0033198
- GO:0034220
- GO:0034405
- GO:0035590
- GO:0042118
- GO:0043536
- GO:0050850
- GO:0051899
- GO:0055117
- GO:0055119
- GO:0070588
- GO:0071318
- GO:0097190
- GO:1904141
- GO:2001028
- GO:0005765
- GO:0005886
- GO:0016020
- GO:0030054
- GO:0048471
- GO:0070062
- GO:0001614
- GO:0004931
- GO:0005515
- GO:0005524
- GO:0042802
- GO:0045296
- GO:0099604
increased urinary sodium excretion
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased urinary sodium excretion
- nervous system
- renal
- immune
PubMed 28216264increased urine excretion
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased urine excretion
- nervous system
- renal
- immune
PubMed 28216264decreased convulsions
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased convulsions
- nervous system
- renal
- immune
PubMed 28216264decreased inflammation
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased inflammation
- nervous system
- renal
- immune
PubMed 28216264hemolysis
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: hemolysis
- nervous system
- renal
- immune
PubMed 28216264increased pain
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased pain
- nervous system
- renal
- immune
PubMed 28216264neurodegeneration
Effects
- Activation/Increase/Upregulation: chronic
Studies
- preclinical: neurodegeneration
- nervous system
- renal
- immune
PubMed 28216264decreased pain
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased pain
- nervous system
- renal
- immune
PubMed 28216264
Related records
Trials (663)
- 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics
- 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension
- 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
- A 6 Week Study to Determine the Effectiveness of R228060 in Adult Subjects With Major Depressive Disorder
- A Bioequivalence Study of Amlodipine / Valsartan From Amlodipine/Valsartan 10/160 Tablets (Pharmacare, Palestine) and Exforge Tablets (Novartis Pharma, USA)
- A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan
- A Bioequivalence Study of Amlodipine Plus Losartan Versus Amlodipine and Losartan
- A Bioequivalence Study of Valsartan / Amlodipine From Valsartan and Amlodipine Tablets (Hua Yuan Pharmaceutical LLC, China) and Valsartan and Amlodipine Tablets (Ⅰ) (Novartis Pharma Schweiz AG, Switzerland)
- A Causal Role for Voltage-gated Cav1.2 Calcium Channels in Mediating 5G FR1 Effects on Sleep-associated Brain Health in Humans
- A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure.
- A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
- A Clinical Trial to Evaluate the Pharmacokinetics and Safety of Fimasartan and Amlodipine in Healthy Male Subjects
- A Combination Therapy In Patients With Social Anxiety Disorder
- A Comparative Study Between Amlodipine 10mg And 5mg With Hypertension For Whom 5mg Is Insufficient
- A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study)
- A Dose Selection Trial of CKD-330 in Patients With Essential Hypertension
- A Drug Interaction Study of 31001074 and Paroxetine in Healthy Volunteers
Drugs (4)
- Adenosine triphosphate
- Amlodipine
- Nimodipine
- Paroxetine