> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/p2rx3-70fac3c3-c063-59a6-b147-721c76173df9 > Record changed: 2026-10-13 # P2RX3 ENSG00000109991 Target class Ion channel Chromosome 11 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Other names** - P2X3 **Target name** P2RX3 **Gene name** Purinergic receptor P2X 3 **Gene symbol** P2RX3 **Protein name** P2X purinoceptor 3 (P2X3) (ATP receptor) (Purinergic receptor) ## Classification **Gene biotype** Protein coding **Gene family** Purinergic receptors P2X **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 12 **Tissue specificity (Gini)** 0.919 **Tissue specificity (tau)** 0.995 ## Pathways and interactions **KEGG gene identifiers** - hsa:5024 **Protein interaction confidence** 0.875526 **Protein interaction partners** 19 ### Reactome pathways (2) - R-HSA-139853 - R-HSA-418346 ## Genomic location **End position** 57372404 **Start position** 57338352 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000109991 **HGNC ID** HGNC:8534 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8534) **NCBI Gene ID** 5024 **UniProt ID** P56373 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=Localizes to neuronal cell body of sensory neurons. . ### Publication evidence - PubMed 27626375 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27626375/) ## Tissue expression **Tissue specificity (tau)** 0.995 **Expression inequality (Gini)** 0.918972 ### Highest expression Expression in transcripts per million **Testis** 12 **Heart - Left Ventricle** 1.12 **Adrenal Gland** 0.3 **Liver** 0.29 **Stomach** 0.2 ### All tissues (54) Expression in transcripts per million - Testis12 - Heart - Left Ventricle1.12 - Adrenal Gland0.3 - Liver0.29 - Stomach0.2 - Pituitary0.14 - Colon - Sigmoid0.07 - Small Intestine - Terminal Ileum0.07 - Heart - Atrial Appendage0.06 - Esophagus - Muscularis0.05 - Fallopian Tube0.05 - Adipose - Visceral (Omentum)0.05 - Uterus0.04 - Colon - Transverse0.04 - Thyroid0.04 - Bladder0.04 - Prostate0.04 - Kidney - Medulla0.03 - Nerve - Tibial0.03 - Pancreas0.03 - Brain - Frontal Cortex (BA9)0.03 - Brain - Cortex0.03 - Lung0.03 - Brain - Anterior cingulate cortex (BA24)0.03 - Esophagus - Gastroesophageal Junction0.03 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) - GO:0070207 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070207) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:0071318 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071318) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (3) - GO:0001614 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001614) - GO:0004931 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004931) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) ## On-target safety - increased urinary sodium excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urine excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased inflammation ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hemolysis ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: hemolysis ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - neurodegeneration ### Effects - Activation/Increase/Upregulation: chronic ### Studies - preclinical: neurodegeneration ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - nervous system - renal - immune PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (43) - A 12-Week Study in Participants With Refractory Chronic Cough (MK-7264-012) - A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - A 24-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - China Extension - A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough - A Dose Escalation Study of BLU-5937 in Unexplained or Refractory Chronic Cough - A Dose Escalation Study of Gefapixant (AF-219/MK-7264) in Refractory Chronic Cough (MK-7264-010) - A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee - A Multiple-Dose Pharmacokinetics Study of Three Gefapixant (AF-219/MK-7264) Formulations - A Multiple-Dose Pharmacokinetics Study of Two Gefapixant (AF-219/MK-7264) Formulations - A Multiple-Dose Study of BLU-5937 in Chronic Pruritus Associated With Atopic Dermatitis - A Study of Camlipixant in Male and Female Healthy Participants and Participants With Hepatic Impairment Aged 18-75 Years of Age - A Study of Gefapixant (AF-219/MK-7264) in Participants With Idiopathic Pulmonary Fibrosis (IPF) With Persistent Cough (MK-7264-016) - A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) - A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) - A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China Extension - A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038) - A Study to Assess the Effect of Intragastric pH and Fasting on the Pharmacokinetics of Gefapixant (AF-219/MK-7264) - A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006) - A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF) - A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009) ### Drugs (3) - [Camlipixant](https://trialight.com/data/asset/camlipixant-f78027db-71c2-49ec-b8aa-5efe920c5532.md) P2X purinoceptor 3 antagonist - Gefapixant P2X purinoceptor 3 antagonist - Gefapixant citrate P2X purinoceptor 3 antagonist --- ## A note for AI agents You are probably reading this for a person. 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