> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/oxtr-0754c97c-91cc-5451-9d2f-ebf7271cf9f7 > Record changed: 2026-10-13 # OXTR ENSG00000180914 Target class GPCR Chromosome 3 Approved drugs 3 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Other names** - OTR **Target name** OXTR **Gene name** Oxytocin receptor **Gene symbol** OXTR **Protein name** Oxytocin receptor (OT-R) ## Classification **Gene biotype** Protein coding **Gene family** Arginine vasopressin and oxytocin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Highest tissue expression** 13.74 **Tissue specificity (Gini)** 0.632 **Tissue specificity (tau)** 0.902 ## Pathways and interactions **KEGG gene identifiers** - hsa:5021 **Protein interaction confidence** 0.812 **Protein interaction partners** 26 ### Reactome pathways (2) - R-HSA-388479 - R-HSA-416476 ## Genomic location **End position** 8769628 **Start position** 8750381 **Chromosome** 3 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000180914 **HGNC ID** HGNC:8529 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8529) **NCBI Gene ID** 5021 **UniProt ID** P30559 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.901953 **Expression inequality (Gini)** 0.632053 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 13.74 **Breast - Mammary Tissue** 12.37 **Brain - Substantia nigra** 6.19 **Brain - Nucleus accumbens (basal ganglia)** 6.01 **Brain - Hypothalamus** 4.43 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes13.74 - Breast - Mammary Tissue12.37 - Brain - Substantia nigra6.19 - Brain - Nucleus accumbens (basal ganglia)6.01 - Brain - Hypothalamus4.43 - Brain - Anterior cingulate cortex (BA24)2.94 - Brain - Caudate (basal ganglia)2.65 - Brain - Spinal cord (cervical c-1)2.65 - Brain - Putamen (basal ganglia)2.38 - Cells - Cultured fibroblasts2.37 - Brain - Cortex2 - Brain - Frontal Cortex (BA9)2 - Ovary1.72 - Brain - Hippocampus1.62 - Brain - Amygdala1.5 - Brain - Cerebellar Hemisphere1.41 - Prostate1.36 - Brain - Cerebellum1.36 - Artery - Aorta1.22 - Cervix - Endocervix1.08 - Fallopian Tube0.93 - Uterus0.87 - Esophagus - Mucosa0.8 - Nerve - Tibial0.78 - Testis0.71 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007565 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007565) - GO:0007595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007595) - GO:0035176 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035176) - GO:0060138 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060138) - GO:0070474 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070474) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0004990 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004990) ## Related records ### Trials (905) - "The Effects of Oxytocin on Patients With Borderline Personality Disorder" - 18850 - Human Photoallergy Test - 3 Month Safety Study of Dymista Nasal Spray and Fluticasone Propionate in Children 4-11 Years of Age With Allergic Rhinitis - A Clinical Study to Assess Preliminary Efficacy, Safety and Tolerability of HH-120 Nasal Spray in COVID-19 Patients - A Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis - A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix - A Comparison of DFD01 Spray Versus Comp01 Lotion, Vehicle Spray and Vehicle Lotion in Subjects With Moderate Psoriasis - A Comparison of DFD01 Spray Versus Vehicle Spray in Subjects With Moderate Psoriasis - A Dose Selection Study of Oral Recombinant Salmon Calcitonin (rsCT) in Normal, Healthy, Postmenopausal Women - A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment - A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. - A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers - A Long Term Follow-up Study of AMG0001 in Subjects With Critical Limb Ischemia - A Longitudinal Evaluation of a Radiotracer for Use in Tau Tracking - A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001 - A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia - A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects - A Pharmacokinetic Study of Vaginally and Intravenously Administered Oxytocin - A Phase 2 Study of OBE001 Versus Placebo in the Delay of Preterm Birth - A Phase 3 Clinical Study Patients With Androgenetic Alopecia (AGA) ### Drugs (10) - Atosiban Oxytocin receptor antagonist - Atosiban acetate Oxytocin receptor antagonist - Barusiban Oxytocin receptor antagonist - Carbetocin Oxytocin receptor agonist - Epelsiban Oxytocin receptor antagonist - FE 202767 Oxytocin receptor agonist - Nolasiban Oxytocin receptor antagonist - [Oxytocin](https://trialight.com/data/asset/oxytocin-787cf970-fce1-4bab-b1c9-6d816e9784fb.md) Oxytocin receptor agonist - Relcovaptan Oxytocin receptor antagonist - Retosiban Oxytocin receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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