OXTR
ENSG00000180914
Target class
GPCR
Chromosome
3
Approved drugs
3
Clinical candidates (approved and in development)
10
- Approved drugs
- 3
- Clinical candidates (approved and in development)
- 10
- Chemical probe available
- Yes
- Other names
- OTR
- Target name
- OXTR
- Gene name
- Oxytocin receptor
- Gene symbol
- OXTR
- Protein name
- Oxytocin receptor (OT-R)
- Gene biotype
- Protein coding
- Gene family
- Arginine vasopressin and oxytocin receptors
- Target class
- GPCR
- Target type
- Human gene
- Tissues expressed in
- 20
- Highest tissue expression
- 13.74
- Tissue specificity (Gini)
- 0.632
- Tissue specificity (tau)
- 0.902
- KEGG gene identifiers
- hsa:5021
- Protein interaction confidence
- 0.812
- Protein interaction partners
- 26
- R-HSA-388479
- R-HSA-416476
- End position
- 8769628
- Start position
- 8750381
- Chromosome
- 3
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein.
- Tissue specificity (tau)
- 0.901953
- Expression inequality (Gini)
- 0.632053
Expression in transcripts per million
- Cells - EBV-transformed lymphocytes
- 13.74
- Breast - Mammary Tissue
- 12.37
- Brain - Substantia nigra
- 6.19
- Brain - Nucleus accumbens (basal ganglia)
- 6.01
- Brain - Hypothalamus
- 4.43
Expression in transcripts per million
- Cells - EBV-transformed lymphocytes13.74
- Breast - Mammary Tissue12.37
- Brain - Substantia nigra6.19
- Brain - Nucleus accumbens (basal ganglia)6.01
- Brain - Hypothalamus4.43
- Brain - Anterior cingulate cortex (BA24)2.94
- Brain - Caudate (basal ganglia)2.65
- Brain - Spinal cord (cervical c-1)2.65
- Brain - Putamen (basal ganglia)2.38
- Cells - Cultured fibroblasts2.37
- Brain - Cortex2
- Brain - Frontal Cortex (BA9)2
- Ovary1.72
- Brain - Hippocampus1.62
- Brain - Amygdala1.5
- Brain - Cerebellar Hemisphere1.41
- Prostate1.36
- Brain - Cerebellum1.36
- Artery - Aorta1.22
- Cervix - Endocervix1.08
- Fallopian Tube0.93
- Uterus0.87
- Esophagus - Mucosa0.8
- Nerve - Tibial0.78
- Testis0.71
And 29 more, listed on the interactive page.
- GO:0006936
- GO:0007166
- GO:0007193
- GO:0007200
- GO:0007565
- GO:0007595
- GO:0035176
- GO:0060138
- GO:0070474
Cellular components
- GO:0005886
Molecular functions
- GO:0004990
Related records
Trials (905)
- "The Effects of Oxytocin on Patients With Borderline Personality Disorder"
- 18850 - Human Photoallergy Test
- 3 Month Safety Study of Dymista Nasal Spray and Fluticasone Propionate in Children 4-11 Years of Age With Allergic Rhinitis
- A Clinical Study to Assess Preliminary Efficacy, Safety and Tolerability of HH-120 Nasal Spray in COVID-19 Patients
- A Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis
- A Comparison of Balloon Catheter Versus Ocytocin for Cervical Ripening on Scarred Uterus With Unfavorable Cervix
- A Comparison of DFD01 Spray Versus Comp01 Lotion, Vehicle Spray and Vehicle Lotion in Subjects With Moderate Psoriasis
- A Comparison of DFD01 Spray Versus Vehicle Spray in Subjects With Moderate Psoriasis
- A Dose Selection Study of Oral Recombinant Salmon Calcitonin (rsCT) in Normal, Healthy, Postmenopausal Women
- A Drug Safety and Dose-exploratory Clinical Study of Azvudine Tablets in Patients Who Have Not Received Anti-HIV Treatment
- A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296.
- A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers
- A Long Term Follow-up Study of AMG0001 in Subjects With Critical Limb Ischemia
- A Longitudinal Evaluation of a Radiotracer for Use in Tau Tracking
- A Open Label Extension Study for Subjects That Complete Study MP-101-CL-001
- A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia
- A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects
- A Pharmacokinetic Study of Vaginally and Intravenously Administered Oxytocin
- A Phase 2 Study of OBE001 Versus Placebo in the Delay of Preterm Birth
- A Phase 3 Clinical Study Patients With Androgenetic Alopecia (AGA)
Drugs (10)
- Atosiban Oxytocin receptor antagonist
- Atosiban acetate Oxytocin receptor antagonist
- Barusiban Oxytocin receptor antagonist
- Carbetocin Oxytocin receptor agonist
- Epelsiban Oxytocin receptor antagonist
- FE 202767 Oxytocin receptor agonist
- Nolasiban Oxytocin receptor antagonist
- Oxytocin Oxytocin receptor agonist
- Relcovaptan Oxytocin receptor antagonist
- Retosiban Oxytocin receptor antagonist