> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/oprm1-04284660-78ba-5225-a86d-21f8a7325d8f
> Record changed: 2026-10-13

# OPRM1

ENSG00000112038

Target class

GPCR

Chromosome

6

Approved drugs

53

Clinical candidates (approved and in development)

69

## Clinical evidence

**Approved drugs**

53

**Clinical candidates (approved and in development)**

69

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

OPRM1

**Gene name**

Opioid receptor mu 1

**Gene symbol**

OPRM1

**Protein name**

Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)

### Other names (2)

- MOR1
- MOP

## Classification

**Gene biotype**

Protein coding

**Gene family**

Opioid receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Highest tissue expression**

2.53

**Tissue specificity (Gini)**

0.938

**Tissue specificity (tau)**

0.979

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4988

**Protein interaction confidence**

0.830543

**Protein interaction partners**

46

### Reactome pathways (6)

- R-HSA-111885
- R-HSA-202040
- R-HSA-375276
- R-HSA-418594
- R-HSA-6785807
- R-HSA-9022699

## Genomic location

**End position**

154246867

**Start position**

154010496

**Chromosome**

6

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000112038

**HGNC ID**

HGNC:8156

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8156)

**NCBI Gene ID**

4988

**UniProt ID**

P35372

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Cell projection, axon . Perikaryon . Cell projection, dendrite . Endosome . Note=Is rapidly internalized after agonist binding. .
- SUBCELLULAR LOCATION: \[Isoform 12\]: Cytoplasm .

### Publication evidence (8)

- PubMed 10529478  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10529478/)
- PubMed 12589820  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12589820/)
- PubMed 16580639  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16580639/)
- PubMed 7891175  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7891175/)
- PubMed 7905839  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7905839/)
- PubMed 7957926  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7957926/)
- PubMed 9689128  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9689128/)
- PubMed 20525224  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20525224/)

## Tissue expression

**Tissue specificity (tau)**

0.97882

**Expression inequality (Gini)**

0.93803

### Highest expression

Expression in transcripts per million

**Testis**

2.53

**Brain - Cerebellum**

1.45

**Brain - Cerebellar Hemisphere**

0.83

**Brain - Nucleus accumbens (basal ganglia)**

0.14

**Brain - Hypothalamus**

0.13

### All tissues (54)

Expression in transcripts per million

- Testis2.53
- Brain - Cerebellum1.45
- Brain - Cerebellar Hemisphere0.83
- Brain - Nucleus accumbens (basal ganglia)0.14
- Brain - Hypothalamus0.13
- Brain - Frontal Cortex (BA9)0.07
- Brain - Cortex0.06
- Brain - Anterior cingulate cortex (BA24)0.04
- Brain - Amygdala0.03
- Brain - Caudate (basal ganglia)0.03
- Pituitary0.01
- Colon - Sigmoid0.01
- Brain - Putamen (basal ganglia)0.01
- Brain - Spinal cord (cervical c-1)0.01
- Fallopian Tube0.01
- Brain - Hippocampus0.01
- Thyroid0
- Uterus0
- Esophagus - Mucosa0
- Brain - Substantia nigra0
- Lung0
- Adrenal Gland0
- Skin - Not Sun Exposed (Suprapubic)0
- Artery - Aorta0
- Bladder0

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0008285  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285)
- GO:0048149  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048149)
- GO:0061358  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061358)
- GO:0080135  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0080135)

### Cellular components (4)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005783  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783)
- GO:0005794  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (3)

- GO:0001965  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001965)
- GO:0004979  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004979)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## On-target safety

- drug abuse/dependence  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: drug abuse/dependence  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased gastric emptying  
### Effects (2)

  - Inhibition/Decrease/Downregulation: acute
  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased gastric emptying  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased anxiety  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased anxiety  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- gas  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: gas  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased gastrointestinal transit  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased gastrointestinal transit  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased cardiac output  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased cardiac output  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urine excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased/increased blood pressure  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood glucose  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood glucose  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased convulsions  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased/increased convulsions  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased convulsions  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased/decreased convulsions  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased gastrointestinal transit  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased gastrointestinal transit  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- scratching  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: scratching  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood insulin  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood insulin  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: pain  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased gastric acid secretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased gastric acid secretion  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased respiratory rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased respiratory rate  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- dyspepsia  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: dyspepsia  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- sedation  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: sedation  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased/decreased memory  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased/decreased memory  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased/increased body temperature  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased/increased pupil diameter  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased/increased pupil diameter  
### Biological samples (6)

  - pancreas
  - nervous system
  - respiratory
  - renal
  - cardiovascular
  - gastrointestinal  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

And 2 more, listed on the interactive page.

## Off-target safety

- decreased gastrointestinal motility  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased gastrointestinal motility  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- hypothermia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: hypothermia  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- respiratory depression  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: respiratory depression  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- flatulence  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: flatulence  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- increased gastrointestinal motility  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: increased gastrointestinal motility  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- miosis  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: miosis  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- sedation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: sedation  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- dyspepsia  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: dyspepsia  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- pupil constriction  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: pupil constriction  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hOpiate\_mu, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hOpiate\_mu assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- abuse liability  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: abuse liability  
### Biological samples (3)

  - cardiovascular system
  - central nervous system
  - gastrointestinal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (4,749)

- "NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?
- "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail
- \[11C\]Carfentanil PET Study of GSK1521498
- 0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy
- 2 Dose Neuraxial Morphine for Prevention of PDPH
- 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain
- 4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans
- 4FMFES-PET Imaging of Endometrial and Ovarian Cancers
- 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
- 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial
- 90% Effective Infusion Time of Sufentanil to Prevent Induction Cough: A Biased Coin Sequential Study
- A 12-week Extension of the Phase III Study (D3820C00004) to Assess the Effect and Safety of NKTR-118 in Patients With Non-cancer-related Pain and Opioid-induced Constipation
- A 15-day Study to Assess the Safety and Clinical Utility of Duragesic (Fentanyl Transdermal Patch) in the Treatment of Children With Continuous Pain Requiring Narcotic Pain Relief Therapy
- A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
- A 2×2 Factorial Randomized Controlled Trial for ERCP
- A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
- A 35 Day Study to Investigate the Effects of GSK1521498 on Bodyweight in Obese Subjects With Over-Eating Behaviours.
- A 5 Treatment Period Pharmacokinetic Study Evaluating Dose Proportionality and Food Effects of Diazoxide Choline Controlled-Release Tablet (DCCR)
- A 58-Week Safety and Efficacy Trial of Ferric Citrate in Patients With ESRD on Dialysis
- A a Single Dose Efficacy Study in Inducing Laxation in Advance Illness Patients

### Drugs (96)

- Alfentanil Mu opioid receptor agonist
- Alfentanil hydrochloride Mu opioid receptor agonist
- Alvimopan Mu opioid receptor antagonist
- Anileridine Mu opioid receptor agonist
- Anileridine hydrochloride Mu opioid receptor agonist
- Anileridine phosphate Mu opioid receptor agonist
- Axelopran Mu opioid receptor antagonist
- Axomadol Mu opioid receptor agonist
- Benzhydrocodone Opioid receptors; mu/kappa/delta agonist
- Benzhydrocodone hydrochloride Opioid receptors; mu/kappa/delta agonist
- Bevenopran Mu opioid receptor antagonist
- [Buprenorphine](https://trialight.com/data/asset/buprenorphine-c075c804-b1a4-4839-84d9-79aa0e258585.md) Mu opioid receptor agonist
- Buprenorphine hydrochloride Mu opioid receptor agonist
- Butorphanol Mu opioid receptor partial agonist
- Butorphanol tartrate Mu opioid receptor partial agonist
- Cebranopadol Opioid receptors; mu/kappa/delta agonist
- Codeine Opioid receptors; mu/kappa/delta agonist
- Codeine phosphate Opioid receptors; mu/kappa/delta agonist
- Codeine polistirex Opioid receptors; mu/kappa/delta agonist
- Codeine sulfate Opioid receptors; mu/kappa/delta agonist

---

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