> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/oprd1-5ce8b0d6-c823-51ce-a7b3-812976633078 > Record changed: 2026-10-13 # OPRD1 ENSG00000116329 Target class GPCR Chromosome 1 Approved drugs 14 Clinical candidates (approved and in development) 21 ## Clinical evidence **Approved drugs** 14 **Clinical candidates (approved and in development)** 21 ## Druggability **Chemical probe available** Yes ## Names **Target name** OPRD1 **Gene name** Opioid receptor delta 1 **Gene symbol** OPRD1 **Protein name** Delta-type opioid receptor (D-OR-1) (DOR-1) ## Classification **Gene biotype** Protein coding **Gene family** Opioid receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 6 **Highest tissue expression** 3.49 **Tissue specificity (Gini)** 0.752 **Tissue specificity (tau)** 0.927 ## Pathways and interactions **KEGG gene identifiers** - hsa:4985 **Protein interaction confidence** 0.8812 **Protein interaction partners** 15 ### Reactome pathways (3) - R-HSA-375276 - R-HSA-418594 - R-HSA-6785807 ## Genomic location **End position** 28871267 **Start position** 28812170 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000116329 **HGNC ID** HGNC:8153 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8153) **NCBI Gene ID** 4985 **UniProt ID** P41143 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 22184124 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22184124/) - PubMed 7808419 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7808419/) - PubMed 8201839 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8201839/) ## Tissue expression **Tissue specificity (tau)** 0.92734 **Expression inequality (Gini)** 0.75239 ### Highest expression Expression in transcripts per million **Brain - Cortex** 3.49 **Brain - Frontal Cortex (BA9)** 3.27 **Brain - Anterior cingulate cortex (BA24)** 1.46 **Brain - Putamen (basal ganglia)** 1.32 **Brain - Caudate (basal ganglia)** 1.23 ### All tissues (54) Expression in transcripts per million - Brain - Cortex3.49 - Brain - Frontal Cortex (BA9)3.27 - Brain - Anterior cingulate cortex (BA24)1.46 - Brain - Putamen (basal ganglia)1.32 - Brain - Caudate (basal ganglia)1.23 - Brain - Nucleus accumbens (basal ganglia)1.08 - Brain - Amygdala0.66 - Brain - Hippocampus0.56 - Brain - Hypothalamus0.45 - Colon - Sigmoid0.38 - Testis0.34 - Small Intestine - Terminal Ileum0.19 - Pituitary0.18 - Spleen0.15 - Colon - Transverse0.12 - Lung0.1 - Brain - Substantia nigra0.1 - Brain - Cerebellum0.1 - Stomach0.1 - Brain - Spinal cord (cervical c-1)0.09 - Brain - Cerebellar Hemisphere0.09 - Pancreas0.09 - Prostate0.08 - Thyroid0.08 - Adipose - Visceral (Omentum)0.07 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0031333 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031333) - GO:0038003 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038003) - GO:0051881 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051881) - GO:0071456 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071456) - GO:0097237 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097237) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004985 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004985) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0038046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038046) ## On-target safety - seizure ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: seizure ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased cardiac output ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased cardiac output ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - euphoria ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: euphoria ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased contractility ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased contractility ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased blood pressure ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased blood pressure ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: convulsions ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - convulsion ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: convulsion ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - respiratory depression ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: respiratory depression ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased bloodflow to the heart ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased bloodflow to the heart ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased bloodflow to the skeletal muscle ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased bloodflow to the skeletal muscle ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - respiratory depression ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: respiratory depression ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased gastrointestinal transit ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased gastrointestinal transit ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased locomotor activity ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - dysphoria ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: dysphoria ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased pain ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased bloodflow to the kidneys ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased bloodflow to the kidneys ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - analgesia ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: analgesia ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased body temperature ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased body temperature ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased pain ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - heart effects ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: heart effects ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased bloodflow to the gastrointestinal tract ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: increased bloodflow to the gastrointestinal tract ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - cardiovascular effects ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: cardiovascular effects ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - psychomimetic effects ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: psychomimetic effects ### Biological samples (2) - cardiovascular system - nervous system Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased anxiety ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased anxiety ### Biological samples - central nervous system PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Off-target safety - dysphoria ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: dysphoria ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased cardiac contractility ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased cardiac contractility ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - psychomimetic effects ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: psychomimetic effects ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - receptor binding ### Studies - biochemical: NVS\_GPCR\_hOpiate\_D1, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hOpiate\_D1 assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - cardiovascular effects ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: cardiovascular effects ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - convulsion ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: convulsion ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased blood pressure ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased blood pressure ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - analgesia ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: analgesia ### Biological samples (2) - cardiovascular system - central nervous system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (1,097) - \[11C\]Carfentanil PET Study of GSK1521498 - 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence - 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial - A 5 Treatment Period Pharmacokinetic Study Evaluating Dose Proportionality and Food Effects of Diazoxide Choline Controlled-Release Tablet (DCCR) - A Bioavailability Study of NALDEBAIN ER Injection and Nalbuphine Injection in Healthy Volunteers. - A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated - A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused - A Clinical Study in Healthy Subjects Which Aims to Investigate the Safety, the Tolerability and the Effects of GRT0151Y and How the Compound is Taken up and Excreted From the Body - A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS - A Clinical Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of Cebranopadol - A Clinical Trial Comparing Buprenorphine Formulations for High Potency Synthetic Opioid Use - A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects. - A Comparison of Oxycodone/Naloxone and Oxycodone After Laparoscopic Hysterectomy - A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy - A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery - A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine - A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective. - A Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of LPM3770164 in Healthy Subjects - A Double-Blind Comparison of Naltrexone and Placebo in Adults With Attention Deficit Hyperactivity Disorder - A Double-Blind, Randomized, Active- and Placebo-Controlled, Multiple-Dose Multi-Center Phase 3 Study of the Safety and Efficacy of CL-108 in the Treatment of Moderate to Severe Acute Pain and Opioid-Induced Nausea and Vomiting (OINV) ### Drugs (30) - ADL-5747 Delta opioid receptor agonist - ADL-5747 FREE BASE Delta opioid receptor agonist - ADL-5859 Delta opioid receptor agonist - Axomadol Delta opioid receptor agonist - AZD-7268 Delta opioid receptor agonist - Benzhydrocodone Opioid receptors; mu/kappa/delta agonist - Benzhydrocodone hydrochloride Opioid receptors; mu/kappa/delta agonist - Cebranopadol Opioid receptors; mu/kappa/delta agonist - Codeine Opioid receptors; mu/kappa/delta agonist - Codeine phosphate Opioid receptors; mu/kappa/delta agonist - Codeine polistirex Opioid receptors; mu/kappa/delta agonist - Codeine sulfate Opioid receptors; mu/kappa/delta agonist - Dextromoramide Opioid receptors; mu/kappa/delta agonist - Hydrocodone Opioid receptors; mu/kappa/delta agonist - Hydrocodone bitartrate Opioid receptors; mu/kappa/delta agonist - Hydrocodone polistirex Opioid receptors; mu/kappa/delta agonist - Nalbuphine Opioid receptors; mu/kappa/delta agonist - Nalbuphine hydrochloride Opioid receptors; mu/kappa/delta agonist - Nalmefene Delta opioid receptor antagonist - Nalmefene hydrochloride dihydrate Delta opioid receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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