> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ntrk3-af5e37df-eb46-5f87-9adb-7e3d8f5d7dc6 > Record changed: 2026-10-13 # NTRK3 ENSG00000140538 Target class Kinase Chromosome 15 Approved drugs 5 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Disputed **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Other names** - TRKC **Target name** NTRK3 **Gene name** Neurotrophic receptor tyrosine kinase 3 **Gene symbol** NTRK3 **Protein name** NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Protein localisation evidence grade** Supported **Highest tissue expression** 32.53 **Tissue specificity (Gini)** 0.616 **Tissue specificity (tau)** 0.883 ## Pathways and interactions **KEGG gene identifiers** - hsa:4916 ### Reactome pathways (10) - R-HSA-1257604 - R-HSA-2219530 - R-HSA-388844 - R-HSA-6811558 - R-HSA-9034013 - R-HSA-9034015 - R-HSA-9034793 - R-HSA-9034864 - R-HSA-9603381 - R-HSA-9603505 ## Genomic location **End position** 88256993 **Start position** 87859751 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000140538 **HGNC ID** HGNC:8033 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8033) **NCBI Gene ID** 4916 **UniProt ID** Q16288 ## Cellular location - Membrane - Single-pass type I membrane protein. - Nuclear membrane - Nucleoli - Nucleoli rim ## Tissue expression **Tissue specificity (tau)** 0.883411 **Expression inequality (Gini)** 0.616411 ### Highest expression Expression in transcripts per million **Artery - Tibial** 32.53 **Artery - Coronary** 22.14 **Artery - Aorta** 21.64 **Brain - Cerebellum** 15.79 **Brain - Cerebellar Hemisphere** 13.87 ### All tissues (54) Expression in transcripts per million - Artery - Tibial32.53 - Artery - Coronary22.14 - Artery - Aorta21.64 - Brain - Cerebellum15.79 - Brain - Cerebellar Hemisphere13.87 - Nerve - Tibial9.2 - Brain - Cortex8.29 - Brain - Frontal Cortex (BA9)7.76 - Brain - Nucleus accumbens (basal ganglia)7.56 - Brain - Caudate (basal ganglia)7.29 - Brain - Anterior cingulate cortex (BA24)6.18 - Brain - Hypothalamus5.04 - Brain - Putamen (basal ganglia)4.94 - Fallopian Tube4.56 - Uterus4.55 - Brain - Amygdala4.52 - Pituitary4.16 - Cervix - Endocervix3.93 - Cervix - Ectocervix3.85 - Brain - Hippocampus3.82 - Brain - Substantia nigra3.65 - Prostate3.02 - Adipose - Subcutaneous2.9 - Breast - Mammary Tissue2.69 - Bladder2.69 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0007507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007507) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0050927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050927) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) ### Cellular components (3) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (4) - GO:0002039 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002039) - GO:0005030 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005030) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0043121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043121) ## Related records ### Trials (125) - A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery - A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) - A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers. - A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients - A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors - A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site - A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients - A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion - A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer - A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study - [A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.](https://trialight.com/data/trial/a-safety-and-efficacy-study-of-2-dosing-regimens-of-53467de5-991b-4a3c-8648-5dcdbb7475e5.md) - A Study Called EPI VITRAKVI to Compare Treatment Results in Patients With Infantile Fibrosarcoma (IFS), a Type of Connective Soft Tissue Cancer, Who Received a Treatment Called Larotrectinib From a Study Called SCOUT With Patient Data From an External Database - A Study Called VICTORIA to Learn More About How Well Larotrectinib Works in Adults With TRK Fusion-positive Cancer by Comparing Larotrectinib Data From Clinical Studies With Data of Other Treatments From Actual Practice - A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response - A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC) - A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK - A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene - A Study of DCC-2701 in Participants With Advanced Solid Tumors - A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC) - A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements ### Drugs (14) - Altiratinib Neurotrophic tyrosine kinase receptor inhibitor - AZD-6918 Neurotrophic tyrosine kinase receptor inhibitor - AZD-7451 NT-3 growth factor receptor inhibitor - [Cenegermin](https://trialight.com/data/asset/cenegermin-c47bd113-cac2-4c57-a094-530d311415a9.md) Neurotrophic tyrosine kinase receptor agonist - CEP-2563 Neurotrophic tyrosine kinase receptor inhibitor - Cep-2563 dihydrochloride Neurotrophic tyrosine kinase receptor inhibitor - Entrectinib Neurotrophic tyrosine kinase receptor inhibitor - Larotrectinib Neurotrophic tyrosine kinase receptor inhibitor - Larotrectinib sulfate Neurotrophic tyrosine kinase receptor inhibitor - Lestaurtinib NT-3 growth factor receptor inhibitor - PLX-7486 NT-3 growth factor receptor inhibitor - Repotrectinib NT-3 growth factor receptor inhibitor - Selitrectinib Neurotrophic tyrosine kinase receptor inhibitor - Taletrectinib Neurotrophic tyrosine kinase receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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