> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ntrk2-99e267c3-da9b-55d5-865c-863a0e2daa55 > Record changed: 2026-10-13 # NTRK2 ENSG00000148053 Target class Kinase Chromosome 9 Approved drugs 5 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** Yes ## Names **Other names** - TRKB **Target name** NTRK2 **Gene name** Neurotrophic receptor tyrosine kinase 2 **Gene symbol** NTRK2 **Protein name** BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 45 **Protein localisation evidence grade** Supported **Highest tissue expression** 79.51 **Tissue specificity (Gini)** 0.659 **Tissue specificity (tau)** 0.796 ## Pathways and interactions **KEGG gene identifiers** - hsa:4915 **Protein interaction confidence** 0.835296 **Protein interaction partners** 81 ### Reactome pathways (14) - R-HSA-1257604 - R-HSA-187024 - R-HSA-2219530 - R-HSA-6811558 - R-HSA-9024909 - R-HSA-9025046 - R-HSA-9026357 - R-HSA-9026519 - R-HSA-9026527 - R-HSA-9028335 - R-HSA-9028731 - R-HSA-9032500 - R-HSA-9032759 - R-HSA-9032845 ## Genomic location **End position** 85095751 **Start position** 84668375 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000148053 **HGNC ID** HGNC:8032 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8032) **NCBI Gene ID** 4915 **UniProt ID** Q16620 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Endosome membrane - Single-pass type I membrane protein . Early endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Postsynaptic density . Note=Internalized to endosomes upon ligand-binding. . - Plasma membrane ### Publication evidence - PubMed 15494731 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15494731/) ## Tissue expression **Tissue specificity (tau)** 0.795659 **Expression inequality (Gini)** 0.659255 ### Highest expression Expression in transcripts per million **Brain - Anterior cingulate cortex (BA24)** 79.51 **Brain - Frontal Cortex (BA9)** 75.02 **Brain - Cortex** 74.24 **Brain - Caudate (basal ganglia)** 73 **Brain - Amygdala** 72.96 ### All tissues (54) Expression in transcripts per million - Brain - Anterior cingulate cortex (BA24)79.51 - Brain - Frontal Cortex (BA9)75.02 - Brain - Cortex74.24 - Brain - Caudate (basal ganglia)73 - Brain - Amygdala72.96 - Brain - Nucleus accumbens (basal ganglia)66.64 - Brain - Putamen (basal ganglia)58.15 - Brain - Hypothalamus40.59 - Brain - Hippocampus40.27 - Artery - Tibial37.53 - Brain - Substantia nigra37.53 - Thyroid35.22 - Nerve - Tibial28.31 - Adipose - Subcutaneous24.58 - Brain - Cerebellar Hemisphere22.29 - Artery - Coronary22.03 - Brain - Cerebellum20.3 - Breast - Mammary Tissue15.23 - Brain - Spinal cord (cervical c-1)14.29 - Vagina8.29 - Kidney - Medulla7.42 - Adipose - Visceral (Omentum)7.09 - Cervix - Ectocervix6.54 - Skin - Sun Exposed (Lower leg)5.83 - Minor Salivary Gland5.71 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0031547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031547) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:1902430 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902430) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (5) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0043121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043121) - GO:0060175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060175) ## Related records ### Trials (125) - A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery - A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP) - A Performance and Bioavailability Study of Entrectinib in Healthy Volunteers. - A Phase 1 Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients - A Phase 1 Study to Evaluate the Potential Drug Interactions Between Repotrectinib and Metformin, Digoxin, and Rosuvastatin in Patients With Advanced Solid Tumors - A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site - A Phase III Study Comparing Taletrectinib With Standard Therapy in ROS1 Positive Locally Advanced or Metastatic Non-small Cell Lung Cancer Patients - A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion - A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer - A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study - [A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.](https://trialight.com/data/trial/a-safety-and-efficacy-study-of-2-dosing-regimens-of-53467de5-991b-4a3c-8648-5dcdbb7475e5.md) - A Study Called EPI VITRAKVI to Compare Treatment Results in Patients With Infantile Fibrosarcoma (IFS), a Type of Connective Soft Tissue Cancer, Who Received a Treatment Called Larotrectinib From a Study Called SCOUT With Patient Data From an External Database - A Study Called VICTORIA to Learn More About How Well Larotrectinib Works in Adults With TRK Fusion-positive Cancer by Comparing Larotrectinib Data From Clinical Studies With Data of Other Treatments From Actual Practice - A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response - A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC) - A Study of AB-106 in Chinese Healthy Adult Men Evaluated the Effects of Itraconazole and Rifampicin on AB-106 PK - A Study of AB-106 in Subjects With Advanced NSCLC Harboring ROS1 Fusion Gene - A Study of DCC-2701 in Participants With Advanced Solid Tumors - A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC) - A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements ### Drugs (14) - Altiratinib Neurotrophic tyrosine kinase receptor inhibitor - AZD-6918 Neurotrophic tyrosine kinase receptor inhibitor - AZD-7451 Neurotrophic tyrosine kinase receptor type 2 inhibitor - [Cenegermin](https://trialight.com/data/asset/cenegermin-c47bd113-cac2-4c57-a094-530d311415a9.md) Neurotrophic tyrosine kinase receptor agonist - CEP-2563 Neurotrophic tyrosine kinase receptor inhibitor - Cep-2563 dihydrochloride Neurotrophic tyrosine kinase receptor inhibitor - Entrectinib Neurotrophic tyrosine kinase receptor inhibitor - Larotrectinib Neurotrophic tyrosine kinase receptor inhibitor - Larotrectinib sulfate Neurotrophic tyrosine kinase receptor inhibitor - Lestaurtinib Neurotrophic tyrosine kinase receptor type 2 inhibitor - PLX-7486 Neurotrophic tyrosine kinase receptor type 2 inhibitor - Repotrectinib Neurotrophic tyrosine kinase receptor type 2 inhibitor - Selitrectinib Neurotrophic tyrosine kinase receptor inhibitor - Taletrectinib Neurotrophic tyrosine kinase receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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