> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ntrk1-b5b86339-81d7-5144-8bbd-570815500165 > Record changed: 2026-10-13 # NTRK1 ENSG00000198400 Target class Kinase Chromosome 1 Approved drugs 6 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 6 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** Yes ## Names **Target name** NTRK1 **Gene name** Neurotrophic receptor tyrosine kinase 1 **Gene symbol** NTRK1 **Protein name** High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA) ### Other names (3) - TRK - TRKA - MTC ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|Immunoglobulin like domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Protein localisation evidence grade** Approved **Highest tissue expression** 5.67 **Tissue specificity (Gini)** 0.541 **Tissue specificity (tau)** 0.79 ## Pathways and interactions **KEGG gene identifiers** - hsa:4914 **Protein interaction confidence** 0.879369 **Protein interaction partners** 111 ### Reactome pathways (9) - R-HSA-167021 - R-HSA-167044 - R-HSA-170984 - R-HSA-177504 - R-HSA-187024 - R-HSA-187042 - R-HSA-187706 - R-HSA-198203 - R-HSA-198745 ## Genomic location **End position** 156881850 **Start position** 156815636 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198400 **HGNC ID** HGNC:8031 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8031) **NCBI Gene ID** 4914 **UniProt ID** P04629 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Early endosome membrane - Single-pass type I membrane protein . Late endosome membrane - Single-pass type I membrane protein . Recycling endosome membrane - Single-pass type I membrane protein . Note=Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. . - Cytosol - Vesicles ### Publication evidence (5) - PubMed 1281417 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1281417/) - PubMed 15488758 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15488758/) - PubMed 17196528 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17196528/) - PubMed 27676246 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27676246/) - PubMed 2927393 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2927393/) ## Tissue expression **Tissue specificity (tau)** 0.79009 **Expression inequality (Gini)** 0.541336 ### Highest expression Expression in transcripts per million **Prostate** 5.67 **Testis** 4.9 **Cervix - Endocervix** 4.25 **Uterus** 3.68 **Fallopian Tube** 3.5 ### All tissues (54) Expression in transcripts per million - Prostate5.67 - Testis4.9 - Cervix - Endocervix4.25 - Uterus3.68 - Fallopian Tube3.5 - Adipose - Visceral (Omentum)3.27 - Colon - Sigmoid3.13 - Kidney - Cortex2.91 - Pituitary2.72 - Brain - Putamen (basal ganglia)2.68 - Esophagus - Gastroesophageal Junction2.38 - Kidney - Medulla2.34 - Brain - Caudate (basal ganglia)2.33 - Esophagus - Muscularis2.11 - Heart - Atrial Appendage1.98 - Lung1.83 - Cervix - Ectocervix1.5 - Brain - Nucleus accumbens (basal ganglia)1.37 - Vagina1.12 - Heart - Left Ventricle1.1 - Thyroid0.97 - Artery - Coronary0.94 - Colon - Transverse0.89 - Stomach0.76 - Adrenal Gland0.74 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (15) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010976) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0038083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038083) - GO:0038180 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038180) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043547) - GO:0046579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046579) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048011 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048011) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:1904646 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904646) - GO:1990090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990090) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (8) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0010465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010465) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:0043121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043121) - GO:0048406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048406) ## On-target safety - grey matter heterotopia ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - weight gain ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - peripheral sensory neuropathy ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Anxiety ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - dizziness ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Cognitive disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - weight loss ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - seizures ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - dysgeusia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - ataxia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - myalgia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - muscle PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - orthostatic hypotension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - epilepsy ### Effects - Activation/Increase/Upregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hTrkA, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hTrkA assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hTrkA, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hTrkA assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (520) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks - 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study ### Drugs (18) - Altiratinib Neurotrophic tyrosine kinase receptor inhibitor - AZD-6918 Neurotrophic tyrosine kinase receptor inhibitor - AZD-7451 Nerve growth factor receptor Trk-A inhibitor - [Cenegermin](https://trialight.com/data/asset/cenegermin-c47bd113-cac2-4c57-a094-530d311415a9.md) Neurotrophic tyrosine kinase receptor agonist - CEP-2563 Neurotrophic tyrosine kinase receptor inhibitor - Cep-2563 dihydrochloride Neurotrophic tyrosine kinase receptor inhibitor - Entrectinib Neurotrophic tyrosine kinase receptor inhibitor - GZ-389988 Nerve growth factor receptor Trk-A inhibitor - Larotrectinib Neurotrophic tyrosine kinase receptor inhibitor - Larotrectinib sulfate Neurotrophic tyrosine kinase receptor inhibitor - Lestaurtinib Nerve growth factor receptor Trk-A inhibitor - Milciclib Nerve growth factor receptor Trk-A inhibitor - Pegcantratinib Nerve growth factor receptor Trk-A inhibitor - PLX-7486 Nerve growth factor receptor Trk-A inhibitor - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Nerve growth factor receptor Trk-A inhibitor - Repotrectinib Nerve growth factor receptor Trk-A inhibitor - Selitrectinib Neurotrophic tyrosine kinase receptor inhibitor - Taletrectinib Neurotrophic tyrosine kinase receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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