> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/nt5e-260380f3-4e4a-56ba-b945-772d6d406143
> Record changed: 2026-10-13

# NT5E

ENSG00000135318

Target class

Enzyme

Chromosome

6

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

NT5E

**Gene name**

5'-nucleotidase ecto

**Gene symbol**

NT5E

**Previous gene symbols**

- NT5

**Protein name**

5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)

### Other names (4)

- CD73
- eN
- eNT
- CALJA

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|5'-nucleotidases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

51

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

191.92

**Tissue specificity (Gini)**

0.582

**Tissue specificity (tau)**

0.913

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4907

**Protein interaction confidence**

0.845189

**Protein interaction partners**

122

### Reactome pathways (4)

- R-HSA-196807
- R-HSA-73621
- R-HSA-74259
- R-HSA-9660826

## Genomic location

**End position**

85495791

**Start position**

85449584

**Chromosome**

6

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000135318

**HGNC ID**

HGNC:8021

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:8021)

**NCBI Gene ID**

4907

**UniProt ID**

P21589

## Cellular location

- Cell membrane
- Lipid-anchor, GPI-anchor .
- Plasma membrane

### Publication evidence (2)

- PubMed 2129526  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2129526/)
- PubMed 24887587  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24887587/)

## Tissue expression

**Tissue specificity (tau)**

0.913016

**Expression inequality (Gini)**

0.581534

### Highest expression

Expression in transcripts per million

**Cells - Cultured fibroblasts**

191.92

**Cervix - Ectocervix**

81.7

**Cervix - Endocervix**

73.76

**Uterus**

55.82

**Artery - Tibial**

47.2

### All tissues (54)

Expression in transcripts per million

- Cells - Cultured fibroblasts191.92
- Cervix - Ectocervix81.7
- Cervix - Endocervix73.76
- Uterus55.82
- Artery - Tibial47.2
- Artery - Aorta46.99
- Ovary45.53
- Vagina43.31
- Fallopian Tube37.27
- Artery - Coronary30.01
- Thyroid29.78
- Nerve - Tibial26.38
- Adipose - Subcutaneous23.04
- Colon - Sigmoid22.74
- Breast - Mammary Tissue19.38
- Bladder18.92
- Colon - Transverse17.56
- Adipose - Visceral (Omentum)15.74
- Esophagus - Gastroesophageal Junction15.3
- Small Intestine - Terminal Ileum14.28
- Prostate13.4
- Brain - Caudate (basal ganglia)12.93
- Esophagus - Muscularis12.57
- Liver11.03
- Pituitary10.88

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0007159  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007159)
- GO:0031214  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031214)
- GO:0033198  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033198)
- GO:0046034  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046034)

### Cellular components (4)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (5)

- GO:0002953  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002953)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008253  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008253)
- GO:0008270  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)

## Related records

### Trials (29)

- A Feasibility Study of Durvalumab +/- Oleclumab as Neoadjuvant Therapy for Muscle-invasive Bladder Cancer (BLASST-2)
- [A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-global-study-to-assess-the-effects-of-durvalumab-with-9b1ffaa8-7388-46c3-8f09-9f534f48bdb9.md)
- A Multi-Cancer, Multi-State, Platform Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Pancreatic Adenocarcinoma, Non-Small Cell Lung Cancer and Squamous Cell Carcinoma of the Head and Neck to Correlate Clinical, Molecular and Immunologic Parameters With DNA Methylation
- A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies
- A Phase 2 Study of Durvalumab (MEDI4736) and Oleclumab (MEDI9447) in Multi-Cancer Populations With Correlation to Clinical, Molecular and Immunologic Parameters With DNA MethylaTION
- A Phase I Study of MEDI9447 (Oleclumab) in Japanese Patients
- A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
- A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC
- A Study to Investigate the Effects of Durvalumab With Oleclumab Following Chemoradiation in Participants With Locally Advanced Unresectable Non-Small Cell Lung Cancer (LADOGA)
- An Open-label, Phase II Study of AZD4635 in Patients With Prostate Cancer
- COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
- Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC
- Durvalumab and Oleclumab in Resectable PDAC
- Gemcitabine, Nab-paclitaxel, Durvalumab, and Oleclumab Before Surgery for the Treatment of in Resectable/Borderline Resectable Primary Pancreatic Cancer
- IPH5201 as Monotherapy or in Combination With Durvalumab +/- Oleclumab in Subjects With Advanced Solid Tumors.
- MEDI9447 Alone and in Combination With MEDI4736 in Adult Participants With Select Advanced Solid Tumors.
- MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study.
- Neo-adjuvant Chemotherapy Combined With Stereotactic Body Radiotherapy to the Primary Tumour +/- Durvalumab, +/- Oleclumab in Luminal B Breast Cancer:
- [Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-treatment-in-resectable-non-small-c5704130-e063-4bfd-817c-edc38351eb37.md)
- Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer

### Drugs (1)

- [Oleclumab](https://trialight.com/data/asset/oleclumab-139659b0-af92-40b9-87db-3fe0f315881b.md) 5'-nucleotidase inhibitor

---

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