> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/nr4a2-2cd5853d-2a40-56f6-a6e4-42791daa0608
> Record changed: 2026-11-04

# NR4A2

ENSG00000153234

Target class

Nuclear receptor

Chromosome

2

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

No

## Names

**Target name**

NR4A2

**Gene name**

Nuclear receptor subfamily 4 group A member 2

**Gene symbol**

NR4A2

**Previous gene symbols**

- NURR1

**Protein name**

Nuclear receptor subfamily 4 group A member 2 (Immediate-early response protein NOT) (Orphan nuclear receptor NURR1) (Transcriptionally-inducible nuclear receptor)

### Other names (4)

- TINUR
- NOT
- RNR1
- HZF-3

## Classification

**Gene biotype**

Protein coding

**Gene family**

Nuclear receptor subfamily 4 group A

**Target class**

Nuclear receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

145.8

**Tissue specificity (Gini)**

0.568

**Tissue specificity (tau)**

0.9

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4929

**Protein interaction confidence**

0.804412

**Protein interaction partners**

17

### Reactome pathways (2)

- R-HSA-383280
- R-HSA-4090294

## Genomic location

**End position**

156342348

**Start position**

156324432

**Chromosome**

2

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000153234

**HGNC ID**

HGNC:7981

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7981)

**NCBI Gene ID**

4929

**UniProt ID**

P43354

## Cellular location

- Cytoplasm . Nucleus . Note=Mostly nuclear
- oxidative stress promotes cytoplasmic localization. .
- Nuclear speckles

### Publication evidence (2)

- PubMed 23283970  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23283970/)
- PubMed 17184956  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17184956/)

## Tissue expression

**Tissue specificity (tau)**

0.89995

**Expression inequality (Gini)**

0.567592

### Highest expression

Expression in transcripts per million

**Ovary**

145.8

**Nerve - Tibial**

90.99

**Artery - Tibial**

65.03

**Pituitary**

49.38

**Adipose - Visceral (Omentum)**

48.13

### All tissues (54)

Expression in transcripts per million

- Ovary145.8
- Nerve - Tibial90.99
- Artery - Tibial65.03
- Pituitary49.38
- Adipose - Visceral (Omentum)48.13
- Fallopian Tube35.21
- Brain - Cerebellar Hemisphere32.98
- Artery - Aorta29.12
- Brain - Cerebellum28.54
- Artery - Coronary25.96
- Lung20.81
- Prostate19.07
- Breast - Mammary Tissue17.96
- Thyroid17.93
- Adipose - Subcutaneous17.54
- Cervix - Ectocervix14.26
- Stomach13.9
- Heart - Atrial Appendage13.78
- Skin - Not Sun Exposed (Suprapubic)13.49
- Cervix - Endocervix13.49
- Vagina13.22
- Skin - Sun Exposed (Lower leg)13
- Esophagus - Gastroesophageal Junction12.22
- Minor Salivary Gland11.61
- Adrenal Gland11.35

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (7)

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)
- GO:0001764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001764)
- GO:0006351  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006351)
- GO:0045944  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944)
- GO:0060070  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060070)
- GO:1904948  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904948)
- GO:2001234  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001234)

### Cellular components (5)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0016607  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016607)
- GO:0032991  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991)

### Molecular functions (6)

- GO:0003677  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677)
- GO:0004879  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008013  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008013)
- GO:0046965  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046965)
- GO:1990837  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837)

## Off-target safety

- regulation of transcription factor activity  
### Studies

  - cell-based: ATG\_NURR1\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.  
### Biological samples

  - HepG2, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (10)

- A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19)
- IMU-838 and Oseltamivir in the Treatment of COVID-19
- MRI Trial to exPlore the efficAcy and Safety of IMU-838 in Relapsing Remitting Multiple Sclerosis (EMPhASIS)
- Phase 2 Dose-finding IMU-838 for Ulcerative Colitis
- SC12267 (4SC-101) for Treatment of Patients With Inflammatory Bowel Disease
- SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis
- Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
- [Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis](https://trialight.com/data/trial/study-to-evaluate-the-efficacy-safety-and-tolerability-of-665fcf6f-6866-41ff-9315-5f5492c442a2.md)
- [Study to Evaluate the Efficacy, Safety, and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis](https://trialight.com/data/trial/study-to-evaluate-the-efficacy-safety-and-tolerability-of-05478f01-85fa-4160-8fdf-e5be4837c847.md)
- Vidofludimus Calcium for Primary Sclerosing Cholangitis

### Drugs (1)

- [Vidofludimus](https://trialight.com/data/asset/vidofludimus-8f773f25-2942-44a3-b9f6-884b9088a0f0.md)

---

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