> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/nr3c2-ddf600eb-ddcf-5af5-b7a0-935d2b5ed817 > Record changed: 2026-10-13 # NR3C2 ENSG00000151623 Target class Nuclear receptor Chromosome 4 Approved drugs 11 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 11 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** Yes ## Names **Other names** - MR **Target name** NR3C2 **Gene name** Nuclear receptor subfamily 3 group C member 2 **Gene symbol** NR3C2 **Previous gene symbols** - MLR **Protein name** Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 3 group C **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Supported **Highest tissue expression** 19.31 **Tissue specificity (Gini)** 0.292 **Tissue specificity (tau)** 0.667 ## Pathways and interactions **KEGG gene identifiers** - hsa:4306 **Protein interaction confidence** 0.827792 **Protein interaction partners** 24 ### Reactome pathways (2) - R-HSA-3371497 - R-HSA-4090294 ## Genomic location **End position** 148445549 **Start position** 148078762 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000151623 **HGNC ID** HGNC:7979 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7979) **NCBI Gene ID** 4306 **UniProt ID** P08235 ## Cellular location - Cytoplasm. Nucleus. Endoplasmic reticulum membrane - Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand - nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.666641 **Expression inequality (Gini)** 0.292267 ### Highest expression Expression in transcripts per million **Thyroid** 19.31 **Ovary** 13.12 **Colon - Transverse** 12.65 **Brain - Cerebellar Hemisphere** 11.97 **Cervix - Ectocervix** 11.78 ### All tissues (54) Expression in transcripts per million - Thyroid19.31 - Ovary13.12 - Colon - Transverse12.65 - Brain - Cerebellar Hemisphere11.97 - Cervix - Ectocervix11.78 - Artery - Tibial11.26 - Small Intestine - Terminal Ileum10.69 - Pituitary10.46 - Brain - Cerebellum10.14 - Nerve - Tibial10.02 - Bladder9.91 - Cervix - Endocervix9.58 - Colon - Sigmoid9.46 - Brain - Frontal Cortex (BA9)8.95 - Minor Salivary Gland8.57 - Breast - Mammary Tissue8.16 - Adipose - Subcutaneous8.07 - Testis8.04 - Brain - Cortex7.79 - Uterus7.65 - Kidney - Medulla7.37 - Lung7.32 - Fallopian Tube6.83 - Artery - Aorta6.64 - Vagina6.3 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:1901224 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901224) ### Cellular components (3) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (5) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017025) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## Off-target safety - regulation of steroid hormone biosynthetic process ### Studies (6) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies - cell-based ### Biological samples - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid biosynthetic process ### Studies (8) - cell-based: CEETOX\_H295R\_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (883) - "Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes" - "E4/DRSP Endocrine Function, Metabolic Control and Hemostasis Study" - "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - 601 Versus Ranibizumab in Patients With Branch Retinal Vein Occlusion (BRVO) - 601 Versus Ranibizumab in Patients With Central Retinal Vein Occlusion (CRVO) - A Bioequivalence Study Between Fluticasone Propionate 250 mcg and Salmeterol Xinafoate 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 250/50 Inhalation Powder/GSK in Healthy Volunteers - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation, Rin 150 And Individual Reference Drugs In Healthy Volunteers - A Bioequivalence Study of Pegylated Interferon Alfa-2a (PEG-IFN Alfa-2a) Benzyl Alcohol (BA)-Free Formulation Versus PEG-IFN Alfa-2a (Pegasys) Following Subcutaneous Administration - A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease - A Causal Role for Voltage-gated Cav1.2 Calcium Channels in Mediating 5G FR1 Effects on Sleep-associated Brain Health in Humans - A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching - A Clinical Study of IMC-001 for Injection in Improving Atherosclerotic Plaque Stability in Patients With Acute Coronary Syndrome. - A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries - A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS) - A Comparative Study of New Formulation and Approved Formulation for Levothyroxine in Healthy Volunteers - A Comparing Study Between SJ04 and Ovidrel® in Healthy Subjects - A Comparison Of Outcomes In Patients In New York Heart Association (NYHA) Class II Heart Failure When Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Medicines - A Cross-over Study Examining the Bioequivalence of 3 Test Formulations to a Reference Formulation of Alectinib (RO5424802) in Healthy Volunteers - A Crossover Study to Evaluate the Relative Bioavailability of Two Formulations of Deuterated Remdesivir Hydrobromide for Oral Suspension in Healthy Chinese Adults - A Drug-Drug Interaction Study Between HS-10374 Tablets and Drospirenone and Ethinyl Estradiol Tablets(Yasmin®) ### Drugs (18) - [Balcinrenone](https://trialight.com/data/asset/balcinrenone-039aff61-faf5-4267-bfc5-f89dce767007.md) Mineralocorticoid receptor modulator - Canrenoate Mineralocorticoid receptor antagonist - Canrenoate potassium Mineralocorticoid receptor antagonist - Canrenone Mineralocorticoid receptor antagonist - Desoxycorticosterone acetate Mineralocorticoid receptor agonist - Desoxycorticosterone pivalate Mineralocorticoid receptor agonist - [Drospirenone](https://trialight.com/data/asset/drospirenone-9b602c10-48da-4ba8-ace9-5b9f942ad491.md) Mineralocorticoid receptor antagonist - Eplerenone Mineralocorticoid receptor antagonist - Felodipine Mineralocorticoid receptor antagonist - [Finerenone](https://trialight.com/data/asset/finerenone-e8453ce2-da00-4096-b589-903ae1d466ba.md) Mineralocorticoid receptor antagonist - [Fludrocortisone acetate](https://trialight.com/data/asset/fludrocortisone-acetate-86ac4ece-968a-47e6-a7c4-a66d7488601a.md) Mineralocorticoid receptor agonist - LY2623091 Mineralocorticoid receptor antagonist - MT-3995 Mineralocorticoid receptor antagonist - Nimodipine Mineralocorticoid receptor antagonist - PF-03882845 Mineralocorticoid receptor antagonist - [Spironolactone](https://trialight.com/data/asset/spironolactone-93f75de1-5c35-41da-89b4-bb7fd4b3da51.md) Mineralocorticoid receptor antagonist - Vamorolone Mineralocorticoid receptor antagonist - XL550 Mineralocorticoid receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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