NR3C2

ENSG00000151623
Target class
Nuclear receptor
Chromosome
4
Approved drugs
11
Clinical candidates (approved and in development)
17

Approved drugs
11
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
17

Chemical probe available
Yes

Other names
  • MR
Target name
NR3C2
Gene name
Nuclear receptor subfamily 3 group C member 2
Gene symbol
NR3C2
Previous gene symbols
  • MLR
Protein name
Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)

Gene biotype
Protein coding
Gene family
Nuclear receptor subfamily 3 group C
Target class
Nuclear receptor
Target type
Human gene

Tissues expressed in
51
Protein localisation evidence grade
Supported
Highest tissue expression
19.31
Tissue specificity (Gini)
0.292
Tissue specificity (tau)
0.667

KEGG gene identifiers
  • hsa:4306
Protein interaction confidence
0.827792
Protein interaction partners
24

  • R-HSA-3371497
  • R-HSA-4090294

End position
148445549
Start position
148078762
Chromosome
4
Strand
Reverse

Ensembl gene ID
ENSG00000151623
HGNC ID
HGNC:7979
www.genenames.org
NCBI Gene ID
4306
UniProt ID
P08235

  • Cytoplasm. Nucleus. Endoplasmic reticulum membrane
  • Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand
  • nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
  • Nucleoplasm

Tissue specificity (tau)
0.666641
Expression inequality (Gini)
0.292267

Expression in transcripts per million

Thyroid
19.31
Ovary
13.12
Colon - Transverse
12.65
Brain - Cerebellar Hemisphere
11.97
Cervix - Ectocervix
11.78

Expression in transcripts per million

  • Thyroid19.31
  • Ovary13.12
  • Colon - Transverse12.65
  • Brain - Cerebellar Hemisphere11.97
  • Cervix - Ectocervix11.78
  • Artery - Tibial11.26
  • Small Intestine - Terminal Ileum10.69
  • Pituitary10.46
  • Brain - Cerebellum10.14
  • Nerve - Tibial10.02
  • Bladder9.91
  • Cervix - Endocervix9.58
  • Colon - Sigmoid9.46
  • Brain - Frontal Cortex (BA9)8.95
  • Minor Salivary Gland8.57
  • Breast - Mammary Tissue8.16
  • Adipose - Subcutaneous8.07
  • Testis8.04
  • Brain - Cortex7.79
  • Uterus7.65
  • Kidney - Medulla7.37
  • Lung7.32
  • Fallopian Tube6.83
  • Artery - Aorta6.64
  • Vagina6.3

And 29 more, listed on the interactive page.

  • regulation of steroid hormone biosynthetic process

    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).

    Biological samples

    • H295R, cell line
    Evidence source
    www.epa.gov

  • regulation of transcription factor activity

    Studies

    • cell-based

    Biological samples

    • HepG2, cell line
    Evidence source
    www.epa.gov

  • regulation of steroid biosynthetic process

    • cell-based: CEETOX_H295R_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.

    Biological samples

    • H295R, cell line
    Evidence source
    www.epa.gov

Related records

Trials (883)

Drugs (18)