> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/nr3c1-98974b8d-fb89-5483-955e-d4a994c71532 > Record changed: 2026-10-13 # NR3C1 ENSG00000113580 Target class Nuclear receptor Chromosome 5 Approved drugs 64 Clinical candidates (approved and in development) 75 ## Clinical evidence **Approved drugs** 64 **Clinical candidates (approved and in development)** 75 ## Druggability **Chemical probe available** Yes ## Names **Other names** - GR **Target name** NR3C1 **Gene name** Nuclear receptor subfamily 3 group C member 1 **Gene symbol** NR3C1 **Previous gene symbols** - GRL **Protein name** Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1) ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 3 group C **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 55.25 **Tissue specificity (Gini)** 0.318 **Tissue specificity (tau)** 0.711 ## Pathways and interactions **KEGG gene identifiers** - hsa:2908 **Protein interaction confidence** 0.847921 **Protein interaction partners** 89 ### Reactome pathways (7) - R-HSA-3371497 - R-HSA-4090294 - R-HSA-8849473 - R-HSA-8939902 - R-HSA-9615017 - R-HSA-9679191 - R-HSA-9768777 ## Genomic location **End position** 143435512 **Start position** 143277931 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113580 **HGNC ID** HGNC:7978 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7978) **NCBI Gene ID** 2908 **UniProt ID** P04150 ## Cellular location - \[Isoform Alpha\]: Cytoplasm . Nucleus . Mitochondrion . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome . Nucleus, nucleoplasm . Note=After ligand activation, translocates from the cytoplasm to the nucleus (PubMed:30698747). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment (By similarity). In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity). Upon dexamethasone binding associates with the glucocorticoid response elements of target genes (By similarity). . - SUBCELLULAR LOCATION: \[Isoform Beta\]: Nucleus . Cytoplasm . Note=Expressed predominantly in the nucleus with some expression also detected in the cytoplasm. . - SUBCELLULAR LOCATION: \[Isoform Alpha-B\]: Nucleus . Cytoplasm . Note=After ligand activation, translocates from the cytoplasm to the nucleus. . - Cytosol - Mitochondria - Nucleoplasm ### Publication evidence (11) - PubMed 15769988 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15769988/) - PubMed 17635946 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17635946/) - PubMed 18838540 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18838540/) - PubMed 27120390 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27120390/) - PubMed 30698747 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30698747/) - PubMed 8621628 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8621628/) - PubMed 21664385 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21664385/) - PubMed 25847991 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25847991/) - PubMed 19248771 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19248771/) - PubMed 26711253 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26711253/) - PubMed 15866175 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15866175/) ## Tissue expression **Tissue specificity (tau)** 0.710981 **Expression inequality (Gini)** 0.317627 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 55.25 **Nerve - Tibial** 34.46 **Adipose - Subcutaneous** 34.13 **Cells - Cultured fibroblasts** 33.59 **Artery - Tibial** 32.69 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes55.25 - Nerve - Tibial34.46 - Adipose - Subcutaneous34.13 - Cells - Cultured fibroblasts33.59 - Artery - Tibial32.69 - Brain - Cerebellar Hemisphere28.96 - Adipose - Visceral (Omentum)26.4 - Breast - Mammary Tissue26.18 - Lung24.74 - Brain - Cerebellum24.3 - Artery - Coronary23.97 - Esophagus - Muscularis22.92 - Artery - Aorta22.51 - Vagina21.85 - Esophagus - Gastroesophageal Junction21.7 - Thyroid21.37 - Cervix - Ectocervix21.14 - Skin - Sun Exposed (Lower leg)20.77 - Uterus20.66 - Muscle - Skeletal20.17 - Pituitary19.78 - Cervix - Endocervix19.51 - Fallopian Tube18.52 - Bladder18.52 - Skin - Not Sun Exposed (Suprapubic)18.27 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (10) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0071383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071383) - GO:0071385 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071385) - GO:0071549 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071549) - GO:0071560 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071560) - GO:1902895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902895) ### Cellular components (8) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005759 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005759) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016607) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) ### Molecular functions (15) - GO:0000977 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000977) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0001046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001046) - GO:0001227 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001227) - GO:0001228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001228) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0004883 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004883) - GO:0005496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005496) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017025) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0051879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051879) - GO:1990239 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990239) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## On-target safety - decreased memory ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased memory ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood potassium ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood potassium ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increase, hypertension ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/214) - decreased wound repair ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased wound repair ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased blood glucose ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased blood glucose ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Decreased sperm quantity / quality in the adult, Decreased fertility ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/66) - increased urinary sodium excretion ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased/decreased pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased/decreased pain ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - impaired, Fertility ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/64) - lipid redistribution ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: lipid redistribution ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Decrease, Population growth rate ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/334) - Decreased sperm quantity or quality in the adult, Decreased fertility ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/71) - increased inflammation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased inflammation ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased memory ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased memory ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increased, Liver Steatosis ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/318) - Increased, agitation ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/214) - decreased muscle mass ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased muscle mass ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increased, depression ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/214) - insulin resistance ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: insulin resistance ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased inflammation ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased inflammation ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased blood pressure ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - endometrial thickening ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: endometrial thickening ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increased, seizure ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/214) - fatigue ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: fatigue ### Biological samples (3) - nervous system - immune - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) And 2 more, listed on the interactive page. ## Off-target safety - regulation of transcription factor activity ### Studies (6) - cell-based: TOX21\_GR\_BLA\_Antagonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based: ATG\_GRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: TOX21\_GR\_BLA\_Agonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) substrate used as the measure of target activity. - cell-based: ATG\_GRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_GR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_GR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples (2) - HeLa, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - immunosuppression ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: immunosuppression ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - insulin resistance ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: insulin resistance ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - muscle wasting ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: muscle wasting ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - receptor binding ### Studies - biochemical: NVS\_NR\_hGR, is one of one assay component(s) measured or calculated from the NVS\_NR\_hGR assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - increased body weight ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased body weight ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - regulation of steroid biosynthetic process ### Studies (8) - cell-based: CEETOX\_H295R\_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTIC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_CORTISOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_DOC, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_11DCORT, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - cardiac arrhythmia ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: cardiac arrhythmia ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased blood pressure ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased blood pressure ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - regulation of steroid hormone biosynthetic process ### Studies (6) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - glaucoma ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: glaucoma ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - osteoporosis ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: osteoporosis ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased plasma potassium ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: decreased plasma potassium ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - hyperglycaemia ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: hyperglycaemia ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - hypoglycaemia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: hypoglycaemia ### Biological samples (2) - immune - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (9,260) - "A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation" - "Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice - "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis - "Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery" - "Monoclonal Antibodies for Treatment of Multiple Myeloma. Emphasis on the CD38 Antibody Daratumumab " - "Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" - "Platelet-Rich Plasma" Epidural Injection an Emerging Strategy in Lumbar Disc Herniation - "Randomized Controlled Trial Testing the Efficacy of Corticosteroid Therapy Versus Placebo in Fibrotic Hypersensitivity Pneumonitis" - "Selinexor+Pegaspargase+Dexamethasone"in Ⅰ/Ⅱ NKTCL - "Steroids and Azathioprine Versus Steroids Alone in IgAN" - "The Importance of Adding Fenestration to Ultrasound-Guided Baker's Cyst Aspiration" - "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department" - (CARE Network Trial - Treating Children to Prevent Exacerbations of Asthma (TREXA) - (CB-01-02/01) Randomized Placebo Controlled Trial of Budesonide-multi-matrix System (MMX™) 6 mg and 9 mg in Patients With Ulcerative Colitis - (CB-01-02/02) Randomized Placebo Controlled Trial of Budesonide-multi-matrix System (MMX™) 6 mg and 9 mg in Patients With Ulcerative Colitis - (CB-01-02/04) Extension Study of Budesonide Multi-Matrix System (MMX) 6 mg in Maintenance Of Remission In Patients With Ulcerative Colitis. - (CB-01-02/06) Oral Budesonide-Multi-Matrix System (MMX) 9mg Extended Release Tablets - 05-001: Treatment of Acute Lymphoblastic Leukemia in Children - 10% Dextrose Versus Triamcinolone Injections After Pulsed Radiofrequency for Herniated Nucleus Pulposus - 101-PGC-005 for the Treatment of COVID-19 ### Drugs (82) - ABBV-3373 Glucocorticoid receptor modulator - Alclometasone dipropionate Glucocorticoid receptor agonist - Amcinonide Glucocorticoid receptor agonist - AZD-5423 Glucocorticoid receptor modulator - [Beclomethasone dipropionate](https://trialight.com/data/asset/beclomethasone-dipropionate-068d01cb-b921-4eda-85ad-1921f6683476.md) Glucocorticoid receptor agonist - Betamethasone Glucocorticoid receptor agonist - Betamethasone acetate Glucocorticoid receptor agonist - Betamethasone benzoate Glucocorticoid receptor agonist - Betamethasone dipropionate Glucocorticoid receptor agonist - Betamethasone phosphoric acid Glucocorticoid receptor agonist - Betamethasone sodium phosphate Glucocorticoid receptor agonist - Betamethasone valerate Glucocorticoid receptor agonist - [Budesonide](https://trialight.com/data/asset/budesonide-15e6ba7b-3021-46e9-b180-bf23025bbc67.md) Glucocorticoid receptor agonist - Ciclesonide Glucocorticoid receptor agonist - Clobetasol propionate Glucocorticoid receptor agonist - Clocortolone pivalate Glucocorticoid receptor agonist - CORT 108297 Glucocorticoid receptor antagonist - Cortisone acetate Glucocorticoid receptor agonist - Cortivazol Glucocorticoid receptor agonist - Cyproterone acetate Glucocorticoid receptor antagonist --- ## A note for AI agents You are probably reading this for a person. 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