> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/nr2e1-843a88f7-04a6-5898-a849-484675d6d4ff > Record changed: 2026-11-04 # NR2E1 ENSG00000112333 Target class Nuclear receptor Chromosome 6 ## Druggability **Chemical probe available** No ## Names **Target name** NR2E1 **Gene name** Nuclear receptor subfamily 2 group E member 1 **Gene symbol** NR2E1 **Previous gene symbols** - TLX **Protein name** Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll) ### Other names (2) - TLL - XTLL ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 2 group E **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 10 **Protein localisation evidence grade** Approved **Highest tissue expression** 19.98 **Tissue specificity (Gini)** 0.85 **Tissue specificity (tau)** 0.892 ## Pathways and interactions **KEGG gene identifiers** - hsa:7101 **Protein interaction confidence** 0.8297 **Protein interaction partners** 10 ### Reactome pathways (2) - R-HSA-383280 - R-HSA-8943724 ## Genomic location **End position** 108188805 **Start position** 108166022 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000112333 **HGNC ID** HGNC:7973 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7973) **NCBI Gene ID** 7101 **UniProt ID** Q9Y466 ## Cellular location - Nucleus . - Nuclear bodies ## Tissue expression **Tissue specificity (tau)** 0.891977 **Expression inequality (Gini)** 0.850246 ### Highest expression Expression in transcripts per million **Brain - Caudate (basal ganglia)** 19.98 **Brain - Anterior cingulate cortex (BA24)** 17.31 **Brain - Cortex** 17.05 **Brain - Nucleus accumbens (basal ganglia)** 16.59 **Brain - Amygdala** 15.69 ### All tissues (54) Expression in transcripts per million - Brain - Caudate (basal ganglia)19.98 - Brain - Anterior cingulate cortex (BA24)17.31 - Brain - Cortex17.05 - Brain - Nucleus accumbens (basal ganglia)16.59 - Brain - Amygdala15.69 - Brain - Frontal Cortex (BA9)15.6 - Brain - Putamen (basal ganglia)13.18 - Brain - Hippocampus8.29 - Brain - Hypothalamus5.85 - Brain - Substantia nigra3.48 - Adrenal Gland0.36 - Testis0.15 - Brain - Cerebellum0.13 - Whole Blood0.12 - Brain - Spinal cord (cervical c-1)0.11 - Brain - Cerebellar Hemisphere0.1 - Skin - Sun Exposed (Lower leg)0.06 - Skin - Not Sun Exposed (Suprapubic)0.06 - Pituitary0.06 - Spleen0.04 - Minor Salivary Gland0.03 - Pancreas0.03 - Kidney - Cortex0.02 - Esophagus - Mucosa0.02 - Stomach0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399) ### Cellular components - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) ### Molecular functions (3) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## Related records ### Trials (172) - "AIDA" Protocol (LAP 0493) - 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) - A Clinical Study Evaluating the Efficacy and Safety of Retinoic Acid in Patients With 15q11-q13 Duplication Syndrome - A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel - A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging - A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy - A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment - A Single-arm Trial of Roxadustat Combined With Retinoic Acid in the Treatment of Refractory Low-risk MDS - A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne - A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris - [A Study Comparing Tretinoin Gel Microsphere, 0.04% and RETIN-A MICRO ® Gel Microsphere, 0.04% in the Treatment of Acne Vulgaris](https://trialight.com/data/trial/a-study-comparing-tretinoin-gel-microsphere-0-04-and-retin-a-bceeb42d-138a-465f-8e49-d6992398bd3a.md) - A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris - A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) - A Study of ATRA in the Treatment of ITP - A Study of Bomedemstat (IMG-7289/MK-3543) With and Without ATRA, in Participants With Advanced Myeloid Malignancies (IMG-7289-CTP-101/MK-3543-001) - A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple Myeloma - A Study of Different Use Regimens Using Two Acne Treatments - A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products - A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of Rosacea - A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma ### Drugs (1) - [Tretinoin](https://trialight.com/data/asset/tretinoin-4d914613-55d9-4e09-ba53-7b0b1526992b.md) --- ## A note for AI agents You are probably reading this for a person. 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