> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/nr1i2-40bab506-b45a-5acc-acc5-9834cb940ee5 > Record changed: 2026-11-04 # NR1I2 ENSG00000144852 Target class Nuclear receptor Chromosome 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** NR1I2 **Gene name** Nuclear receptor subfamily 1 group I member 2 **Gene symbol** NR1I2 **Protein name** Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR) ### Other names (5) - ONR1 - PXR - BXR - SXR - PAR2 ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 1 group I **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Protein localisation evidence grade** Supported **Highest tissue expression** 42.58 **Tissue specificity (Gini)** 0.909 **Tissue specificity (tau)** 0.982 ## Pathways and interactions **KEGG gene identifiers** - hsa:8856 **Protein interaction confidence** 0.810209 **Protein interaction partners** 43 ## Genomic location **End position** 119818487 **Start position** 119780484 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000144852 **HGNC ID** HGNC:7968 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7968) **NCBI Gene ID** 8856 **UniProt ID** O75469 ## Cellular location - Nucleus . Cytoplasm . - Nucleoplasm ### Publication evidence (2) - PubMed 12606758 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12606758/) - PubMed 26534988 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26534988/) ## Tissue expression **Tissue specificity (tau)** 0.982027 **Expression inequality (Gini)** 0.908579 ### Highest expression Expression in transcripts per million **Liver** 42.58 **Small Intestine - Terminal Ileum** 21.27 **Colon - Transverse** 11.15 **Cells - EBV-transformed lymphocytes** 1.51 **Brain - Hypothalamus** 0.59 ### All tissues (54) Expression in transcripts per million - Liver42.58 - Small Intestine - Terminal Ileum21.27 - Colon - Transverse11.15 - Cells - EBV-transformed lymphocytes1.51 - Brain - Hypothalamus0.59 - Spleen0.44 - Testis0.44 - Pituitary0.41 - Adrenal Gland0.35 - Kidney - Medulla0.3 - Ovary0.23 - Thyroid0.22 - Brain - Nucleus accumbens (basal ganglia)0.21 - Nerve - Tibial0.18 - Pancreas0.15 - Brain - Caudate (basal ganglia)0.15 - Colon - Sigmoid0.15 - Kidney - Cortex0.14 - Brain - Frontal Cortex (BA9)0.14 - Fallopian Tube0.14 - Brain - Anterior cingulate cortex (BA24)0.14 - Prostate0.13 - Lung0.13 - Brain - Cortex0.12 - Brain - Substantia nigra0.11 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0006805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006805) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008202 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008202) - GO:0042178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042178) - GO:0042908 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042908) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) ### Molecular functions (6) - GO:0000977 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000977) - GO:0001228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001228) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016922 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016922) - GO:1990837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990837) ## On-target safety - Increased, Liver Steatosis ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/60) - Loss, Cochlear function ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/8) ## Off-target safety - regulation of steroid hormone biosynthetic process ### Studies (3) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of transcription factor activity ### Studies (4) - cell-based: ATG\_PXRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_PXR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_PXRE\_CIS, is one of 52 assay component(s) measured or calculated from the ATG\_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: ATG\_PXR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - receptor binding ### Studies - biochemical: NVS\_NR\_hPXR, is one of one assay component(s) measured or calculated from the NVS\_NR\_hPXR assay. It is designed to make measurements of fluorescent resonance energy transfer, a form of binding reporter, as detected with fluorescent resonance energy transfer signals by Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (4,442) - 'ADVANCE' (A Pilot Trial) - "Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer - "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" - \[18F\]FLT PET/CT in Rb+ Metastatic Breast Cancer - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - 17-N-Allylamino-17-Demethoxygeldanamycin and Paclitaxel in Treating Patients With Metastatic or Unresectable Solid Tumor - 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam - 1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer - 2-arm Trial of Paclitaxel Plus Bevacizumab vs. Capecitabine Plus Bevacizumab - 2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB. - 3-AP Plus Cisplatin and Paclitaxel in Treating Patients With Advanced or Metastatic Cancer - 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women - 4 Versus 6 Courses of Adjuvant Chemotherapy in LACC Patients Previously Treated With NACT Plus Radical Surgery - 8 Continuous vs 8 Intermittent Cycles in First and Second Line in HER2/Neu Neg Metastatic Breast Cancer - 9-ING-41 in Patients With Advanced Cancers - 9-ING-41 Plus Retifanlimab and Gemcitabine/Nab-Paclitaxel in Patients With Advanced Pancreatic Adenocarcinoma - A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808) - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil - A 4-week Study of Mifepristone in the Prevention of Risperidone-induced Weight Gain in Healthy Male Volunteers ### Drugs (8) - Clotrimazole - [Estradiol](https://trialight.com/data/asset/estradiol-0b121e99-a1da-433f-be00-a9b7e9d5f80c.md) - Lovastatin - Mifepristone - Nifedipine - [Paclitaxel](https://trialight.com/data/asset/paclitaxel-889db92c-df97-46a6-bf1c-74974a87fa75.md) - Phenobarbital - Rifampin --- ## A note for AI agents You are probably reading this for a person. 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