NR1I2

ENSG00000144852
Target class
Nuclear receptor
Chromosome
3

Chemical probe available
Yes

Target name
NR1I2
Gene name
Nuclear receptor subfamily 1 group I member 2
Gene symbol
NR1I2
Protein name
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)

  • ONR1
  • PXR
  • BXR
  • SXR
  • PAR2

Gene biotype
Protein coding
Gene family
Nuclear receptor subfamily 1 group I
Target class
Nuclear receptor
Target type
Human gene

Tissues expressed in
4
Protein localisation evidence grade
Supported
Highest tissue expression
42.58
Tissue specificity (Gini)
0.909
Tissue specificity (tau)
0.982

KEGG gene identifiers
  • hsa:8856
Protein interaction confidence
0.810209
Protein interaction partners
43

End position
119818487
Start position
119780484
Chromosome
3
Strand
Forward

Ensembl gene ID
ENSG00000144852
HGNC ID
HGNC:7968
www.genenames.org
NCBI Gene ID
8856
UniProt ID
O75469

  • Nucleus . Cytoplasm .
  • Nucleoplasm

Tissue specificity (tau)
0.982027
Expression inequality (Gini)
0.908579

Expression in transcripts per million

Liver
42.58
Small Intestine - Terminal Ileum
21.27
Colon - Transverse
11.15
Cells - EBV-transformed lymphocytes
1.51
Brain - Hypothalamus
0.59

Expression in transcripts per million

  • Liver42.58
  • Small Intestine - Terminal Ileum21.27
  • Colon - Transverse11.15
  • Cells - EBV-transformed lymphocytes1.51
  • Brain - Hypothalamus0.59
  • Spleen0.44
  • Testis0.44
  • Pituitary0.41
  • Adrenal Gland0.35
  • Kidney - Medulla0.3
  • Ovary0.23
  • Thyroid0.22
  • Brain - Nucleus accumbens (basal ganglia)0.21
  • Nerve - Tibial0.18
  • Pancreas0.15
  • Brain - Caudate (basal ganglia)0.15
  • Colon - Sigmoid0.15
  • Kidney - Cortex0.14
  • Brain - Frontal Cortex (BA9)0.14
  • Fallopian Tube0.14
  • Brain - Anterior cingulate cortex (BA24)0.14
  • Prostate0.13
  • Lung0.13
  • Brain - Cortex0.12
  • Brain - Substantia nigra0.11

And 29 more, listed on the interactive page.

  • Increased, Liver Steatosis

    Effects

    • Activation/Increase/Upregulation

    Studies

    • cell-based
    Evidence source
    aopwiki.org

  • Loss, Cochlear function

    Effects

    • Activation/Increase/Upregulation

    Studies

    • cell-based
    Evidence source
    aopwiki.org

  • regulation of steroid hormone biosynthetic process

    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).

    Biological samples

    • H295R, cell line
    Evidence source
    www.epa.gov

  • regulation of transcription factor activity

    • cell-based: ATG_PXRE_CIS, is one of 52 assay component(s) measured or calculated from the ATG_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
    • cell-based: ATG_PXR_TRANS, is one of 30 assay component(s) measured or calculated from the ATG_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
    • cell-based: ATG_PXRE_CIS, is one of 52 assay component(s) measured or calculated from the ATG_CIS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.
    • cell-based: ATG_PXR_TRANS, is one of 30 assay component(s) measured or calculated from the ATG_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology.

    Biological samples

    • HepG2, cell line
    Evidence source
    www.epa.gov

  • receptor binding

    Studies

    • biochemical: NVS_NR_hPXR, is one of one assay component(s) measured or calculated from the NVS_NR_hPXR assay. It is designed to make measurements of fluorescent resonance energy transfer, a form of binding reporter, as detected with fluorescent resonance energy transfer signals by Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (4,442)

Drugs (8)