> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ngfr-c2f57875-9ce4-5eae-91c0-8a865dc6d746 > Record changed: 2026-11-04 # NGFR ENSG00000064300 Target class Membrane receptor Chromosome 17 ## Druggability **Chemical probe available** No ## Names **Target name** NGFR **Gene name** Nerve growth factor receptor **Gene symbol** NGFR **Protein name** Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271) ### Other names (3) - TNFRSF16 - CD271 - p75NTR ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Tumor necrosis factor receptor superfamily|MicroRNA protein coding host genes **Target class** Membrane receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 50 **Protein localisation evidence grade** Approved **Highest tissue expression** 374.41 **Tissue specificity (Gini)** 0.593 **Tissue specificity (tau)** 0.952 ## Pathways and interactions **KEGG gene identifiers** - hsa:4804 **Protein interaction confidence** 0.848066 **Protein interaction partners** 91 ### Reactome pathways (11) - R-HSA-193634 - R-HSA-193648 - R-HSA-193670 - R-HSA-193681 - R-HSA-193692 - R-HSA-205017 - R-HSA-205025 - R-HSA-205043 - R-HSA-209543 - R-HSA-209560 - R-HSA-209563 ## Genomic location **End position** 49515008 **Start position** 49495293 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000064300 **HGNC ID** HGNC:7809 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7809) **NCBI Gene ID** 4804 **UniProt ID** P08138 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Cytoplasm . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine . - Plasma membrane ### Publication evidence (2) - PubMed 3022937 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/3022937/) - PubMed 22566094 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22566094/) ## Tissue expression **Tissue specificity (tau)** 0.951935 **Expression inequality (Gini)** 0.592723 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 374.41 **Thyroid** 63.98 **Adipose - Visceral (Omentum)** 54.82 **Artery - Coronary** 41.68 **Breast - Mammary Tissue** 39.6 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial374.41 - Thyroid63.98 - Adipose - Visceral (Omentum)54.82 - Artery - Coronary41.68 - Breast - Mammary Tissue39.6 - Heart - Atrial Appendage37.75 - Minor Salivary Gland37 - Prostate36.58 - Spleen36.55 - Cervix - Endocervix35.89 - Colon - Sigmoid31.49 - Adrenal Gland29.54 - Adipose - Subcutaneous29.2 - Artery - Tibial29.16 - Brain - Spinal cord (cervical c-1)28.78 - Fallopian Tube28.53 - Esophagus - Gastroesophageal Junction27.2 - Skin - Sun Exposed (Lower leg)26.97 - Esophagus - Muscularis25.68 - Skin - Not Sun Exposed (Suprapubic)23.73 - Artery - Aorta22.41 - Cervix - Ectocervix20.91 - Vagina20.21 - Pituitary19.51 - Bladder19.47 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0007266 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007266) - GO:0030336 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030336) - GO:0051402 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051402) - GO:0097191 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097191) - GO:1900182 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900182) - GO:1902895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902895) - GO:1903588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903588) - GO:1904646 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904646) - GO:2000353 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000353) ### Cellular components (6) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (8) - GO:0001540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005035 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005035) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0038023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023) ## Related records ### Trials (22) - A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Surgery - [A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.](https://trialight.com/data/trial/a-safety-and-efficacy-study-of-2-dosing-regimens-of-53467de5-991b-4a3c-8648-5dcdbb7475e5.md) - An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops - An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED - Corneal Nerves After Treatment With Cenegermin - Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study - Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity - DEFENDO Long Term Follow-up Study in Stage 1 NK Patients - DOMPE -MT Neurotrophic Keratitis - Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) - Nerve Growth Factor for the Treatment of Cornea Disease - NGF Treatment for Patients With Neuropathic Corneal Pain - OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate - Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis - Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye - Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Study) - Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis - Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease - Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma - Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers ### Drugs (1) - [Cenegermin](https://trialight.com/data/asset/cenegermin-c47bd113-cac2-4c57-a094-530d311415a9.md) --- ## A note for AI agents You are probably reading this for a person. 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