> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ngf-7e37ebac-9206-5c67-8e77-2b598dbe0c2c > Record changed: 2026-10-13 # NGF ENSG00000134259 Target class Secreted protein Chromosome 1 Approved drugs 0 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Strong **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** NGF **Gene name** Nerve growth factor **Gene symbol** NGF **Previous gene symbols** - NGFB **Protein name** Beta-nerve growth factor (Beta-NGF) ## Classification **Gene biotype** Protein coding **Gene family** Neurotrophins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 43 **Highest tissue expression** 33.47 **Tissue specificity (Gini)** 0.605 **Tissue specificity (tau)** 0.817 ## Pathways and interactions **KEGG gene identifiers** - hsa:4803 **Protein interaction confidence** 0.795136 **Protein interaction partners** 88 ### Reactome pathways (19) - R-HSA-167021 - R-HSA-167044 - R-HSA-167060 - R-HSA-170968 - R-HSA-170984 - R-HSA-177504 - R-HSA-187042 - R-HSA-187706 - R-HSA-193648 - R-HSA-193670 - R-HSA-193681 - R-HSA-198203 - R-HSA-198745 - R-HSA-205017 - R-HSA-205025 - R-HSA-205043 - R-HSA-209543 - R-HSA-209560 - R-HSA-209563 ## Genomic location **End position** 115338770 **Start position** 115285904 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000134259 **HGNC ID** HGNC:7808 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7808) **NCBI Gene ID** 4803 **UniProt ID** P01138 ## Cellular location - Secreted . Endosome lumen . Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. . ### Publication evidence - PubMed 20978020 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20978020/) ## Tissue expression **Tissue specificity (tau)** 0.816716 **Expression inequality (Gini)** 0.605199 ### Highest expression Expression in transcripts per million **Ovary** 33.47 **Artery - Aorta** 29.99 **Fallopian Tube** 28.12 **Uterus** 22.64 **Artery - Tibial** 21.92 ### All tissues (54) Expression in transcripts per million - Ovary33.47 - Artery - Aorta29.99 - Fallopian Tube28.12 - Uterus22.64 - Artery - Tibial21.92 - Adipose - Visceral (Omentum)19.42 - Artery - Coronary17.7 - Nerve - Tibial16.53 - Cervix - Endocervix16.47 - Heart - Atrial Appendage16.32 - Cervix - Ectocervix12.99 - Kidney - Medulla8.28 - Bladder7.6 - Vagina7.52 - Heart - Left Ventricle7.21 - Colon - Sigmoid7.14 - Cells - Cultured fibroblasts6.98 - Adipose - Subcutaneous6.61 - Thyroid6.16 - Breast - Mammary Tissue5.62 - Spleen5.54 - Esophagus - Gastroesophageal Junction5.08 - Esophagus - Muscularis4.43 - Prostate3.94 - Kidney - Cortex3.76 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0008625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008625) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0045666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045666) - GO:0048812 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048812) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008191 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008191) ## Related records ### Trials (78) - A Clinical Study To Investigate The Effectiveness And Safety Of Tanezumab In Treating Pain Associated With Endometriosis - A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Low Back Pain - A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain - A Long Term Study of the Safety of Tanezumab When Administered By Subcutaneous Injections - A Phase 1 Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HH-101 in Patients With Advanced Solid Tumors - A Phase 1 Study to Evaluate the Safety of MEDI7814 in Adult Volunteers - A Phase 1, Open Label, Dose-escalation Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 3BNC117 - A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee - A Phase 3 Study of Tanezumab for Chronic Low Back Pain - A Phase II Study Looking at Moderate to Severe Osteoarthritis Knee Pain - [A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis](https://trialight.com/data/trial/a-phase-ii-study-of-ensifentrine-in-non-cystic-fibrosis-2fab3023-2a61-42c9-bc42-81128d34ce1d.md) - A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis - A Single-Dose Study of the Safety and Tolerability of REGN475(SAR164877) in Healthy Subjects - A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for Insomnia - A Study of Effectiveness and Safety of JNJ-42160443 in Patients With Diabetic Painful Neuropathy - A Study Of Tanezumab as Add-On Therapy to Opioid Medication In Patients With Pain Due To Cancer That Has Spread To Bone - A Study of Tanezumab in Adults With Chronic Low Back Pain - A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy - A Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Cancer-related Pain - A Study of the Safety and Efficacy of REGN475(SAR164877) in Patients With Osteoarthritis of the Knee ### Drugs (5) - Fasinumab Beta-nerve growth factor inhibitor - [Fulranumab](https://trialight.com/data/asset/fulranumab-8e0a0038-2b27-4708-a5d0-cd814ebbe1a4.md) Beta-nerve growth factor inhibitor - MEDI-578 Beta-nerve growth factor inhibitor - PG-110 Beta-nerve growth factor inhibitor - Tanezumab Beta-nerve growth factor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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