> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/nectin4-2a0472c2-ddd1-57a8-b5dd-85f1a66f5d52 > Record changed: 2026-10-13 # NECTIN4 ENSG00000143217 Target class Adhesion Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** NECTIN4 **Gene name** Nectin cell adhesion molecule 4 **Gene symbol** NECTIN4 **Previous gene symbols** - PVRL4 **Protein name** Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) \[Cleaved into: Processed poliovirus receptor-related protein 4\] ### Other names (3) - nectin-4 - PRR4 - LNIR ## Classification **Gene biotype** Protein coding **Gene family** V-set domain containing|C2-set domain containing|Nectins and nectin-like molecules **Target class** Adhesion **Target type** Human gene ## Expression and localisation **Tissues expressed in** 17 **Protein localisation evidence grade** Supported **Highest tissue expression** 205.24 **Tissue specificity (Gini)** 0.9 **Tissue specificity (tau)** 0.945 ## Pathways and interactions **KEGG gene identifiers** - hsa:81607 **Protein interaction confidence** 0.923875 **Protein interaction partners** 8 ### Reactome pathways (2) - R-HSA-418990 - R-HSA-420597 ## Genomic location **End position** 161090045 **Start position** 161070988 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000143217 **HGNC ID** HGNC:19688 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:19688) **NCBI Gene ID** 81607 **UniProt ID** Q96NY8 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Cell junction, adherens junction . Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254). - SUBCELLULAR LOCATION: \[Processed poliovirus receptor-related protein 4\]: Secreted . Note=The secreted form is found in breast tumor patients (PubMed:15784625). - Plasma membrane ### Publication evidence (2) - PubMed 11544254 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11544254/) - PubMed 15784625 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15784625/) ## Tissue expression **Tissue specificity (tau)** 0.944742 **Expression inequality (Gini)** 0.900126 ### Highest expression Expression in transcripts per million **Skin - Sun Exposed (Lower leg)** 205.24 **Skin - Not Sun Exposed (Suprapubic)** 203.62 **Esophagus - Mucosa** 148.56 **Vagina** 120.83 **Minor Salivary Gland** 52.05 ### All tissues (54) Expression in transcripts per million - Skin - Sun Exposed (Lower leg)205.24 - Skin - Not Sun Exposed (Suprapubic)203.62 - Esophagus - Mucosa148.56 - Vagina120.83 - Minor Salivary Gland52.05 - Prostate16.91 - Breast - Mammary Tissue16.74 - Bladder9.46 - Lung5.81 - Stomach4.96 - Kidney - Medulla4.05 - Kidney - Cortex2.76 - Pancreas2.69 - Fallopian Tube1.91 - Colon - Transverse1.69 - Testis1.68 - Pituitary1.25 - Small Intestine - Terminal Ileum0.93 - Cells - EBV-transformed lymphocytes0.5 - Thyroid0.44 - Cervix - Endocervix0.39 - Cells - Cultured fibroblasts0.39 - Cervix - Ectocervix0.31 - Adipose - Subcutaneous0.27 - Artery - Coronary0.22 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0045953 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045953) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005912 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005912) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0048018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018) ## Related records ### Trials (75) - A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005) - A Phase 2 Study of Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma - A Safety Study of Enfortumab Vedotin in Indian Adults With Urothelial Cancer - [A Study of ASP2998 Given by Itself and Given With Standard Therapies in People With Solid Tumors](https://trialight.com/data/trial/a-study-of-asp2998-given-by-itself-and-given-with-standard-46343927-76c4-4ff1-b69a-4f9f3b61f6f8.md) - A Study of Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04) - A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer - A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer - A Study of Enfortumab Vedotin in Japanese Subjects With Locally Advanced or Metastatic Urothelial Carcinoma - A Study of Enfortumab Vedotin in People With Adenoid Cystic Carcinoma - A Study of Enfortumab Vedotin in People With Urothelial Carcinoma of the Upper Urinary Tract - A Study of Escalating Doses of ASG-22CE Given as Monotherapy in Subjects With Metastatic Urothelial Cancer and Other Malignant Solid Tumors That Express Nectin-4 - A Study of Evorpacept (ALX148) With Enfortumab Vedotin for Subjects With Urothelial Carcinoma (ASPEN-07) - A Study of Intravesical Enfortumab Vedotin For Treatment of Patients With Non-muscle Invasive Bladder Cancer (NMIBC) - A Study of the Safety and Pharmacokinetics of AGS-22M6E in Subjects With Malignant Solid Tumors That Express Nectin-4 - A Study to Evaluate Enfortumab Vedotin (ASG-22CE) in Chinese Participants With Locally Advanced or Metastatic Urothelial Cancer Who Previously Received Platinum-containing Chemotherapy and Programmed Cell Death Protein-1 ( PD 1) / (Programmed Death Ligand-1 (PD-L1) Inhibitor Therapy - A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) - A Study to Evaluate Enfortumab Vedotin Versus (vs) Chemotherapy in Subjects With Previously Treated Locally Advanced or Metastatic Urothelial Cancer (EV-301) - A Study to Find Out if Enfortumab Vedotin Given With Pembrolizumab Helps People With Muscle-invasive Bladder Cancer Keep Their Bladder - A Study to Survey Adults in South Korea With Cancer Who Receive PADCEV Injection - An Expanded Access Treatment Protocol of Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Urothelial Carcinoma ### Drugs (1) - [Enfortumab vedotin](https://trialight.com/data/asset/enfortumab-vedotin-45d2083d-a27b-4009-b0c7-61fe813e5dea.md) Nectin-4 binding agent --- ## A note for AI agents You are probably reading this for a person. 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