> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ndufs5-ab24df07-8748-5965-824a-93a6f49f81be > Record changed: 2026-10-13 # NDUFS5 ENSG00000168653 Target class Enzyme Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - CI-15k **Target name** NDUFS5 **Gene name** NADH:ubiquinone oxidoreductase subunit S5 **Gene symbol** NDUFS5 **Protein name** NADH dehydrogenase \[ubiquinone\] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit) ## Classification **Gene biotype** Protein coding **Gene family** NADH:ubiquinone oxidoreductase supernumerary subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 647.36 **Tissue specificity (Gini)** 0.164 **Tissue specificity (tau)** 0.381 ## Pathways and interactions **KEGG gene identifiers** - hsa:4725 **Protein interaction confidence** 0.943083 **Protein interaction partners** 96 ### Reactome pathways (2) - R-HSA-611105 - R-HSA-6799198 ## Genomic location **End position** 39034636 **Start position** 39026318 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000168653 **HGNC ID** HGNC:7712 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7712) **NCBI Gene ID** 4725 **UniProt ID** O43920 ## Cellular location - Mitochondrion inner membrane - Peripheral membrane protein . Mitochondrion intermembrane space . ### Publication evidence - PubMed 12611891 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12611891/) ## Tissue expression **Tissue specificity (tau)** 0.38102 **Expression inequality (Gini)** 0.164446 ### Highest expression Expression in transcripts per million **Heart - Left Ventricle** 647.36 **Heart - Atrial Appendage** 627.26 **Brain - Frontal Cortex (BA9)** 613.23 **Colon - Sigmoid** 589.2 **Cells - Cultured fibroblasts** 560.86 ### All tissues (54) Expression in transcripts per million - Heart - Left Ventricle647.36 - Heart - Atrial Appendage627.26 - Brain - Frontal Cortex (BA9)613.23 - Colon - Sigmoid589.2 - Cells - Cultured fibroblasts560.86 - Esophagus - Gastroesophageal Junction554.45 - Brain - Anterior cingulate cortex (BA24)548.74 - Esophagus - Muscularis541.17 - Brain - Nucleus accumbens (basal ganglia)516.55 - Muscle - Skeletal513.67 - Artery - Tibial512.04 - Artery - Coronary493.06 - Uterus490.3 - Artery - Aorta483.32 - Cells - EBV-transformed lymphocytes478.56 - Brain - Cerebellar Hemisphere475.38 - Pituitary467.63 - Fallopian Tube467.59 - Ovary466.43 - Brain - Cortex458.56 - Cervix - Ectocervix440.14 - Brain - Caudate (basal ganglia)437.8 - Brain - Hypothalamus428.62 - Brain - Amygdala412.92 - Cervix - Endocervix403.46 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0032981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032981) ### Cellular components (3) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:0045271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045271) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (2,107) - "Hepatic Substrate Flux Rates in Type 2 Diabetes" - "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome - 1% Metformin Gel in the Treatment of Class II Furcation Defects - 1% Metformin in Moderate and Severe Periodontitis - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) - 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period - A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers - A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers. - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration ### Drugs (4) - ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor - Metformin Mitochondrial complex I (NADH dehydrogenase) inhibitor - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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