> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ndufaf1-7c365e4b-2018-5cb1-8aee-822865bca848 > Record changed: 2026-10-13 # NDUFAF1 ENSG00000137806 Target class Enzyme Chromosome 15 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** NDUFAF1 **Gene name** NADH:ubiquinone oxidoreductase complex assembly factor 1 **Gene symbol** NDUFAF1 **Protein name** Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase \[ubiquinone\] 1 alpha subcomplex assembly factor 1) ### Other names (2) - CIA30 - CGI-65 ## Classification **Gene biotype** Protein coding **Gene family** Mitochondrial respiratory chain complex assembly factors|Mitochondrial complex I assembly complex **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 40.45 **Tissue specificity (Gini)** 0.154 **Tissue specificity (tau)** 0.54 ## Pathways and interactions **KEGG gene identifiers** - hsa:51103 **Reactome pathways** - R-HSA-6799198 **Protein interaction confidence** 0.959065 **Protein interaction partners** 62 ## Genomic location **End position** 41409403 **Start position** 41387218 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000137806 **HGNC ID** HGNC:18828 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18828) **NCBI Gene ID** 51103 **UniProt ID** Q9Y375 ## Cellular location - Mitochondrion . Mitochondrion matrix . Note=Peripherally associated with the matrix face of the mitochondrial inner membrane. . - Mitochondria ### Publication evidence (2) - PubMed 16218961 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16218961/) - PubMed 17557076 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17557076/) ## Tissue expression **Tissue specificity (tau)** 0.539637 **Expression inequality (Gini)** 0.153723 ### Highest expression Expression in transcripts per million **Testis** 40.45 **Adrenal Gland** 37.67 **Cells - Cultured fibroblasts** 34.52 **Muscle - Skeletal** 33.8 **Cells - EBV-transformed lymphocytes** 28.32 ### All tissues (54) Expression in transcripts per million - Testis40.45 - Adrenal Gland37.67 - Cells - Cultured fibroblasts34.52 - Muscle - Skeletal33.8 - Cells - EBV-transformed lymphocytes28.32 - Brain - Frontal Cortex (BA9)25.32 - Heart - Left Ventricle22.76 - Brain - Cerebellar Hemisphere22.57 - Nerve - Tibial21.9 - Brain - Spinal cord (cervical c-1)21.53 - Cervix - Ectocervix21.03 - Ovary20.2 - Brain - Cortex19.98 - Thyroid19.95 - Cervix - Endocervix19.77 - Brain - Cerebellum19.44 - Fallopian Tube19.13 - Uterus19.09 - Pituitary19.01 - Brain - Hypothalamus18.82 - Esophagus - Muscularis18.79 - Kidney - Medulla18.76 - Brain - Anterior cingulate cortex (BA24)18.5 - Colon - Sigmoid18.49 - Artery - Coronary18.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0032981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032981) ### Cellular components (3) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:0160295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160295) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (2,107) - "Hepatic Substrate Flux Rates in Type 2 Diabetes" - "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome - 1% Metformin Gel in the Treatment of Class II Furcation Defects - 1% Metformin in Moderate and Severe Periodontitis - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) - 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period - A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers - A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers. - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration ### Drugs (4) - ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor - Metformin Mitochondrial complex I (NADH dehydrogenase) inhibitor - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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