NDUFA2
ENSG00000131495
Target class
Enzyme
Chromosome
5
Approved drugs
1
Clinical candidates (approved and in development)
3
- Approved drugs
- 1
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 3
- Chemical probe available
- No
- Other names
- B8
- Target name
- NDUFA2
- Gene name
- NADH:ubiquinone oxidoreductase subunit A2
- Gene symbol
- NDUFA2
- Protein name
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)
- Gene biotype
- Protein coding
- Gene family
- NADH:ubiquinone oxidoreductase supernumerary subunits
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 54
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 83.43
- Tissue specificity (Gini)
- 0.107
- Tissue specificity (tau)
- 0.425
- KEGG gene identifiers
- hsa:4695
- Protein interaction confidence
- 0.931409
- Protein interaction partners
- 110
- R-HSA-611105
- R-HSA-6799198
- R-HSA-9837999
- End position
- 140647771
- Start position
- 140638740
- Chromosome
- 5
- Strand
- Reverse
- Mitochondrion inner membrane
- Peripheral membrane protein
- Matrix side .
- Mitochondria
Publication evidence
- PubMed 12611891
- Tissue specificity (tau)
- 0.42471
- Expression inequality (Gini)
- 0.106658
Expression in transcripts per million
- Cells - EBV-transformed lymphocytes
- 83.43
- Testis
- 79.86
- Adrenal Gland
- 70.55
- Kidney - Medulla
- 66.49
- Pituitary
- 61.65
Expression in transcripts per million
- Cells - EBV-transformed lymphocytes83.43
- Testis79.86
- Adrenal Gland70.55
- Kidney - Medulla66.49
- Pituitary61.65
- Muscle - Skeletal59.7
- Thyroid57.79
- Brain - Frontal Cortex (BA9)57.41
- Brain - Cerebellar Hemisphere56.25
- Prostate53.59
- Kidney - Cortex52.03
- Heart - Left Ventricle51.54
- Brain - Anterior cingulate cortex (BA24)51.15
- Brain - Hypothalamus50.94
- Spleen50.87
- Brain - Spinal cord (cervical c-1)50.49
- Fallopian Tube50.45
- Cells - Cultured fibroblasts50.43
- Ovary50.31
- Brain - Nucleus accumbens (basal ganglia)50.27
- Artery - Coronary49.51
- Adipose - Visceral (Omentum)49.21
- Brain - Substantia nigra49.21
- Breast - Mammary Tissue48.51
- Cervix - Endocervix48.39
And 29 more, listed on the interactive page.
- GO:0005739
- GO:0005743
- GO:0031966
- GO:0045271
Related records
Trials (2,107)
- "Hepatic Substrate Flux Rates in Type 2 Diabetes"
- "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome
- 1% Metformin Gel in the Treatment of Class II Furcation Defects
- 1% Metformin in Moderate and Severe Periodontitis
- 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients
- 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes
- 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years
- 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine
- 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064)
- 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period
- A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM)
- A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin
- A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers
- A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers
- A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers.
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
- A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants
- A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration
Drugs (4)
- ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor
- Metformin Mitochondrial complex I (NADH dehydrogenase) inhibitor
- Metformin hydrochloride Mitochondrial complex I (NADH dehydrogenase) inhibitor
- NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor