> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ndufa10-1a66e96a-a0ea-538c-aeda-78dc367fa80e > Record changed: 2026-10-13 # NDUFA10 ENSG00000130414 Target class Enzyme Chromosome 2 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - CI-42k **Target name** NDUFA10 **Gene name** NADH:ubiquinone oxidoreductase subunit A10 **Gene symbol** NDUFA10 **Protein name** NADH dehydrogenase \[ubiquinone\] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) ## Classification **Gene biotype** Protein coding **Gene family** NADH:ubiquinone oxidoreductase supernumerary subunits|Flavoproteins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 95.47 **Tissue specificity (Gini)** 0.178 **Tissue specificity (tau)** 0.623 ## Pathways and interactions **KEGG gene identifiers** - hsa:4705 **Protein interaction confidence** 0.937857 **Protein interaction partners** 91 ### Reactome pathways (2) - R-HSA-611105 - R-HSA-6799198 ## Genomic location **End position** 240025743 **Start position** 239892450 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000130414 **HGNC ID** HGNC:7684 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7684) **NCBI Gene ID** 4705 **UniProt ID** O95299 ## Cellular location - Mitochondrion matrix . - Mitochondria ### Publication evidence - PubMed 12611891 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12611891/) ## Tissue expression **Tissue specificity (tau)** 0.623114 **Expression inequality (Gini)** 0.177626 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 95.47 **Brain - Cerebellum** 92.41 **Nerve - Tibial** 52.41 **Heart - Left Ventricle** 50.09 **Cells - EBV-transformed lymphocytes** 47.7 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere95.47 - Brain - Cerebellum92.41 - Nerve - Tibial52.41 - Heart - Left Ventricle50.09 - Cells - EBV-transformed lymphocytes47.7 - Ovary46.81 - Adrenal Gland46.59 - Skin - Sun Exposed (Lower leg)46.56 - Skin - Not Sun Exposed (Suprapubic)46.04 - Cells - Cultured fibroblasts44.24 - Brain - Frontal Cortex (BA9)42.67 - Heart - Atrial Appendage41.44 - Fallopian Tube41.25 - Uterus41.14 - Brain - Cortex40.36 - Muscle - Skeletal39.86 - Colon - Transverse39.49 - Testis39.39 - Pituitary39.35 - Vagina38.78 - Thyroid38.75 - Cervix - Endocervix38.56 - Esophagus - Mucosa37.99 - Cervix - Ectocervix37.96 - Esophagus - Muscularis37 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (3) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:0045271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045271) ## Related records ### Trials (2,107) - "Hepatic Substrate Flux Rates in Type 2 Diabetes" - "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome - 1% Metformin Gel in the Treatment of Class II Furcation Defects - 1% Metformin in Moderate and Severe Periodontitis - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) - 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period - A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers - A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers. - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration ### Drugs (4) - ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor - Metformin Mitochondrial complex I (NADH dehydrogenase) inhibitor - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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