> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ncstn-60c86f5f-caa9-5ea4-b4a4-21ba2bdf4eb0 > Record changed: 2026-10-13 # NCSTN ENSG00000162736 Target class Enzyme Chromosome 1 Approved drugs 2 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** NCSTN **Gene name** Nicastrin **Gene symbol** NCSTN **Protein name** Nicastrin ### Other names (2) - KIAA0253 - APH2 ## Classification **Gene biotype** Protein coding **Gene family** Gamma-secretase complex subunits **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 123.9 **Tissue specificity (Gini)** 0.237 **Tissue specificity (tau)** 0.638 ## Pathways and interactions **KEGG gene identifiers** - hsa:23385 **Protein interaction confidence** 0.889333 **Protein interaction partners** 21 ### Reactome pathways (15) - R-HSA-1251985 - R-HSA-1474228 - R-HSA-193692 - R-HSA-205043 - R-HSA-2122948 - R-HSA-2644606 - R-HSA-2894862 - R-HSA-2979096 - R-HSA-3928665 - R-HSA-6798695 - R-HSA-9013507 - R-HSA-9013700 - R-HSA-9017802 - R-HSA-977225 - R-HSA-9839383 ## Genomic location **End position** 160358957 **Start position** 160343294 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000162736 **HGNC ID** HGNC:17091 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17091) **NCBI Gene ID** 23385 **UniProt ID** Q92542 ## Cellular location - Membrane - Single-pass type I membrane protein . Cytoplasmic vesicle membrane - Single-pass type I membrane protein . Melanosome . Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Cytosol ### Publication evidence (10) - PubMed 10993067 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10993067/) - PubMed 25043039 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25043039/) - PubMed 25918421 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25918421/) - PubMed 26280335 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26280335/) - PubMed 26623517 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26623517/) - PubMed 26776682 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26776682/) - PubMed 30598546 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30598546/) - PubMed 30630874 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30630874/) - PubMed 12643545 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12643545/) - PubMed 17081065 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17081065/) ## Tissue expression **Tissue specificity (tau)** 0.637903 **Expression inequality (Gini)** 0.236841 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 123.9 **Ovary** 75.84 **Thyroid** 75.3 **Lung** 70.28 **Nerve - Tibial** 68.95 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts123.9 - Ovary75.84 - Thyroid75.3 - Lung70.28 - Nerve - Tibial68.95 - Cervix - Endocervix66.59 - Minor Salivary Gland64.55 - Cervix - Ectocervix63.71 - Spleen62.56 - Adipose - Subcutaneous61.02 - Small Intestine - Terminal Ileum60.54 - Uterus60.03 - Fallopian Tube59.14 - Breast - Mammary Tissue59.01 - Artery - Aorta58.32 - Bladder58.22 - Artery - Coronary57.83 - Testis57.18 - Vagina57.09 - Artery - Tibial55.2 - Pituitary54.99 - Adipose - Visceral (Omentum)54.05 - Skin - Sun Exposed (Lower leg)53.45 - Cells - EBV-transformed lymphocytes52.72 - Skin - Not Sun Exposed (Suprapubic)52.07 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006509) - GO:0007220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007220) - GO:0016485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016485) - GO:0031293 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031293) - GO:0034205 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034205) - GO:0042982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042982) - GO:0042987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042987) ### Cellular components (11) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0030659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030659) - GO:0035577 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035577) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0070765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070765) ### Molecular functions (5) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030674) - GO:0051117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051117) - GO:0061133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061133) - GO:0070851 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070851) ## Related records ### Trials (117) - A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma - A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease - A Phase II, Multicenter, Double Blind, Placebo-Controlled Safety, Tolerability Study of BMS-708163 in Patients With Mild to Moderate Alzheimer's Disease - A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations - A Study Evaluating The PF-03084014 In Combination With Docetaxel In Patients With Advanced Breast Cancer - A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery - A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment - A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response. - A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) - A Study Of PF-03084014 In Japanese Patients With Advanced Solid Tumors - A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy - A Study of Semagacestat for Alzheimer's Patients - A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma - A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers - A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects - [A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments](https://trialight.com/data/trial/a-study-to-examine-the-effects-of-novel-therapy-4622f07a-ab31-4a56-a46c-08b2e34a9258.md) - A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma - A Trial In Patients With Advanced Cancer And Leukemia - A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation - Acute Dose-dependent Effects of DMT in Healthy Subjects ### Drugs (7) - Avagacestat Gamma-secretase inhibitor - Begacestat Gamma-secretase inhibitor - [Nirogacestat](https://trialight.com/data/asset/nirogacestat-3fcb771a-72a0-450b-adde-a88a42aee6e0.md) Gamma-secretase inhibitor - Nirogacestat hydrobromide Gamma-secretase inhibitor - RG-4733 Gamma-secretase inhibitor - Semagacestat Gamma-secretase inhibitor - Tarenflurbil Gamma-secretase modulator --- ## A note for AI agents You are probably reading this for a person. 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