> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ncbp1-74c4f722-b2ab-5553-8fae-b059d351e261
> Record changed: 2026-10-13

# NCBP1

ENSG00000136937

Target class

Unclassified protein

Chromosome

9

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

NCBP1

**Gene name**

Nuclear cap binding protein subunit 1

**Gene symbol**

NCBP1

**Previous gene symbols**

- NCBP

**Protein name**

Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)

### Other names (2)

- CBP80
- Sto1

## Classification

**Gene biotype**

Protein coding

**Gene family**

MIF4G domain containing proteins

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

34.28

**Tissue specificity (Gini)**

0.232

**Tissue specificity (tau)**

0.581

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4686

**Protein interaction confidence**

0.85512

**Protein interaction partners**

191

### Reactome pathways (30)

- R-HSA-111367
- R-HSA-112382
- R-HSA-113418
- R-HSA-159227
- R-HSA-159230
- R-HSA-159231
- R-HSA-159236
- R-HSA-167152
- R-HSA-167158
- R-HSA-167200
- R-HSA-167242
- R-HSA-191859
- R-HSA-674695
- R-HSA-6803529
- R-HSA-6807505
- R-HSA-72086
- R-HSA-72163
- R-HSA-72165
- R-HSA-72187
- R-HSA-72203
- R-HSA-73856
- R-HSA-77588
- R-HSA-77595
- R-HSA-8851708
- R-HSA-9010553

And 5 more, listed on the interactive page.

## Genomic location

**End position**

97673748

**Start position**

97633448

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000136937

**HGNC ID**

HGNC:7658

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7658)

**NCBI Gene ID**

4686

**UniProt ID**

Q09161

## Cellular location

- Nucleus . Cytoplasm . Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
- Cytosol
- Nucleoplasm

### Publication evidence (2)

- PubMed 19648179  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19648179/)
- PubMed 17289661  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17289661/)

## Tissue expression

**Tissue specificity (tau)**

0.580904

**Expression inequality (Gini)**

0.232199

### Highest expression

Expression in transcripts per million

**Cells - EBV-transformed lymphocytes**

34.28

**Cells - Cultured fibroblasts**

33.22

**Testis**

25.66

**Nerve - Tibial**

23.11

**Ovary**

21.33

### All tissues (54)

Expression in transcripts per million

- Cells - EBV-transformed lymphocytes34.28
- Cells - Cultured fibroblasts33.22
- Testis25.66
- Nerve - Tibial23.11
- Ovary21.33
- Cervix - Endocervix21.21
- Brain - Cerebellar Hemisphere21.05
- Thyroid20.8
- Uterus20.49
- Brain - Cerebellum19.97
- Vagina19.16
- Fallopian Tube19.02
- Cervix - Ectocervix18.96
- Bladder18.07
- Pituitary17.98
- Lung17.12
- Skin - Sun Exposed (Lower leg)16.98
- Artery - Coronary16.91
- Artery - Tibial16.8
- Skin - Not Sun Exposed (Suprapubic)16.62
- Prostate16.54
- Artery - Aorta16.52
- Esophagus - Mucosa15.53
- Colon - Transverse15.52
- Small Intestine - Terminal Ileum15.44

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (15)

- GO:0000184  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000184)
- GO:0000245  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000245)
- GO:0006370  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006370)
- GO:0006401  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006401)
- GO:0006406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006406)
- GO:0006408  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006408)
- GO:0006446  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006446)
- GO:0008334  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008334)
- GO:0008380  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008380)
- GO:0016071  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016071)
- GO:0030307  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307)
- GO:0031442  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031442)
- GO:0042789  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042789)
- GO:0048026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048026)
- GO:0051607  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607)

### Cellular components (7)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005846  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005846)
- GO:0034518  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034518)
- GO:1990904  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990904)

### Molecular functions (5)

- GO:0000339  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000339)
- GO:0000340  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000340)
- GO:0003723  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0060090  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060090)

## Related records

### Trials (21)

- A Safety, Pharmacokinetics, and Pharmacodynamics Study of ABX464 in HIV-1 Seronegative and Seropositive Adults
- [ABTECT - Maintenance](https://trialight.com/data/trial/abtect-maintenance-6d0e2081-975d-4bf2-9273-a40f54030ea1.md)
- ABTECT-1 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -1
- ABTECT-2 - ABX464 Treatment Evaluation for Ulcerative Colitis Therapy -2
- ABX464 First in Man Study
- ABX464 in Fully Controlled HIV Infected Patients Treated With Boosted Protease Inhibitor Treatment
- ABX464 in Subjects With Moderate to Severe Active Ulcerative Colitis
- ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
- Dose-Ranging Phase 2b Study of ABX464 in Moderate to Severe Ulcerative Colitis
- Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
- Efficacy and Safety Study of ABX464 as Maintenance Therapy in Patients With Moderate to Severe Ulcerative Colitis
- Evaluation of the Potential CYP1A2-mediated Drug Drug Interaction Safety, and Tolerability of ABX464
- Food Effect on Pharmacokinetic Parameters of ABX464
- Long-term Safety and Efficacy Profile of ABX464 in Subjects With Moderate to Severe Active Ulcerative Colitis
- Phase 2b/3 Study of ABX464 in Moderate to Severe Active Crohn's Disease Patients
- Safety and Pharmacokinetics Study in Healthy Japanese Volunteers
- Safety, PK and PD Study of ABX464 in Untreated HIV Patients
- Study Evaluating the Long-term Safety and Efficacy of ABX464 in Active Ulcerative Colitis
- Study Evaluating the Long-Term Safety and Efficacy of ABX464 in Patients With Moderate to Severe Rheumatoid Arthritis
- Study of Two Doses of ABX464 in Participants With Moderate to Severe Rheumatoid Arthritis

### Drugs (1)

- [Obefazimod](https://trialight.com/data/asset/obefazimod-666d0482-984f-449c-8158-5c055e520eef.md) Cap binding complex modulator

---

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