> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/napepld-ae100410-8d1a-53f0-9993-bb8725b579f2 > Record changed: 2026-11-04 # NAPEPLD ENSG00000161048 Target class Enzyme Chromosome 7 ## Druggability **Chemical probe available** No ## Names **Target name** NAPEPLD **Gene name** N-acyl phosphatidylethanolamine phospholipase D **Gene symbol** NAPEPLD **Protein name** N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54) ### Other names (3) - FMP30 - C7orf18 - NAPE-PLD ## Classification **Gene biotype** Protein coding **Gene family** Metallo-beta-lactamase fold containing family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 32.1 **Tissue specificity (Gini)** 0.285 **Tissue specificity (tau)** 0.701 ## Pathways and interactions **KEGG gene identifiers** - hsa:222236 **Reactome pathways** - R-HSA-2466712 **Protein interaction confidence** 0.8485 **Protein interaction partners** 14 ## Genomic location **End position** 103151172 **Start position** 103099776 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000161048 **HGNC ID** HGNC:21683 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:21683) **NCBI Gene ID** 222236 **UniProt ID** Q6IQ20 ## Cellular location - Golgi apparatus membrane - Peripheral membrane protein . Early endosome membrane - Peripheral membrane protein . Nucleus envelope . Nucleus, nucleoplasm . Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. . ### Publication evidence - PubMed 25684574 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25684574/) ## Tissue expression **Tissue specificity (tau)** 0.700688 **Expression inequality (Gini)** 0.284656 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 32.1 **Brain - Cerebellum** 27.02 **Testis** 20.19 **Ovary** 19.08 **Brain - Frontal Cortex (BA9)** 18.85 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere32.1 - Brain - Cerebellum27.02 - Testis20.19 - Ovary19.08 - Brain - Frontal Cortex (BA9)18.85 - Nerve - Tibial16.71 - Thyroid16.68 - Spleen14.39 - Brain - Spinal cord (cervical c-1)14.36 - Brain - Cortex13.98 - Artery - Aorta13.23 - Cervix - Endocervix12.24 - Cervix - Ectocervix11.94 - Colon - Transverse11.51 - Small Intestine - Terminal Ileum11.13 - Artery - Tibial10.95 - Uterus10.78 - Brain - Anterior cingulate cortex (BA24)10.45 - Artery - Coronary10.29 - Kidney - Medulla10.19 - Brain - Caudate (basal ganglia)9.88 - Brain - Hippocampus9.82 - Prostate9.6 - Pituitary9.45 - Brain - Substantia nigra9.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0070292 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070292) ### Cellular components (6) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005635) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) - GO:0042622 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042622) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0032052 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032052) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0070290 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070290) ## Related records ### Trials (430) - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension - A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome - A Bioequivalence Study of Two Different Formulations of Olmesartan Medoxomil/ Hydrochlorothiazide After a Single Oral Dose Administration Under Fasting Conditions - A Clinical Trial to Evaluate Efficacy, Tolerability, and Pharmacokinetic-Pharmacodynamic Relationship of Fimasartan/Hydrochlorothiazide - A Comparison of Indapamide SR 1.5 mg With HCTZ 25 mg, in Combination With an ACE-inhibitor, in Patients With Mild to Moderate AHT and Type 2 DM - A Comparison of Telmisartan + Hydrochlorothiazide With Amlodipine + Hydrochlorothiazide in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension (ATHOS Study) - A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood Pressure - A Drug to Drug Interaction Study of Sotagliflozin With Hydrochlorothiazide - A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential Hypertension - A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential Hypertension - A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein - A Phase III Long-term Study of TAK-536TCH in Participants With Essential Hypertension - A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD - A Pilot Study of Plasma Renin Activity Guided vs Generic Combination Therapy for Hypertension - A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections - A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People - A Randomized, Double-blind, Parallel-group Assessment of the Safety and Efficacy of Telmisartan 40mg Plus Hydrochlorothiazide 12.5mg (Micardis Plus) in Comparison With Losartan 50mg Plus Hydrochlorothiazide 12.5mg in Taiwanese Patients With Mild to Moderate Hypertension - A Randomized, Double-blind, Placebo Controlled Comparison of Telmisartan Hydrochlorothiazide (HCT) and Valsartan HCT in Hypertension (HTN) Stage I/II Patients - A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly ### Drugs (5) - Bithionol - Chlorthalidone - Hexachlorophene - Hydrochlorothiazide - [Indapamide](https://trialight.com/data/asset/indapamide-38f48c91-8217-4462-9f68-aacc5047dd2a.md) --- ## A note for AI agents You are probably reading this for a person. 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