> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/myl7-92a64fdb-05b7-5beb-8db8-1f144e932487 > Record changed: 2026-10-13 # MYL7 ENSG00000106631 Target class Unclassified protein Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** MYL7 **Gene name** Myosin light chain 7 **Gene symbol** MYL7 **Protein name** Myosin regulatory light chain 2, atrial isoform (MLC-2a) (MLC2a) (Myosin light chain 2a) (Myosin regulatory light chain 7) ### Other names (2) - MYLC2A - MYL2A ## Classification **Gene biotype** Protein coding **Gene family** Myosin light chains, class 2 **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 19 **Highest tissue expression** 7,135.04 **Tissue specificity (Gini)** 0.975 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:58498 **Reactome pathways** - R-HSA-445355 **Protein interaction confidence** 0.8119 **Protein interaction partners** 30 ## Genomic location **End position** 44143179 **Start position** 44138864 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000106631 **HGNC ID** HGNC:21719 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:21719) **NCBI Gene ID** 58498 **UniProt ID** Q01449 ## Tissue expression **Tissue specificity (tau)** 0.998772 **Expression inequality (Gini)** 0.975084 ### Highest expression Expression in transcripts per million **Heart - Atrial Appendage** 7,135.04 **Heart - Left Ventricle** 402.47 **Pituitary** 12.97 **Brain - Cerebellar Hemisphere** 3.62 **Brain - Cerebellum** 3.61 ### All tissues (54) Expression in transcripts per million - Heart - Atrial Appendage7,135.04 - Heart - Left Ventricle402.47 - Pituitary12.97 - Brain - Cerebellar Hemisphere3.62 - Brain - Cerebellum3.61 - Brain - Hypothalamus3.55 - Artery - Coronary1.81 - Artery - Aorta1.73 - Brain - Cortex1.66 - Artery - Tibial1.55 - Brain - Nucleus accumbens (basal ganglia)1.4 - Uterus1.33 - Brain - Frontal Cortex (BA9)1.3 - Vagina1.26 - Breast - Mammary Tissue1.24 - Brain - Anterior cingulate cortex (BA24)1.17 - Nerve - Tibial1.14 - Cervix - Endocervix1.11 - Ovary1.09 - Brain - Amygdala0.98 - Esophagus - Gastroesophageal Junction0.95 - Fallopian Tube0.95 - Cervix - Ectocervix0.94 - Brain - Caudate (basal ganglia)0.94 - Brain - Spinal cord (cervical c-1)0.86 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0031672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031672) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (65) - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Study of CK-1827452 Infusion in Stable Heart Failure - A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) - A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT - A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure - A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants - A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy ### Drugs (3) - Danicamtiv Cardiac myosin activator - [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) Cardiac myosin inhibitor - [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) Cardiac myosin activator --- ## A note for AI agents You are probably reading this for a person. 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