> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/myl4-79a2244f-ffbf-5b90-9021-e71c6659cfd5 > Record changed: 2026-10-13 # MYL4 ENSG00000198336 Target class Unclassified protein Chromosome 17 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** MYL4 **Gene name** Myosin light chain 4 **Gene symbol** MYL4 **Protein name** Myosin light chain 4 (Myosin light chain 1, embryonic muscle/atrial isoform) (Myosin light chain alkali GT-1 isoform) ### Other names (4) - ALC1 - AMLC - GT1 - PRO1957 ## Classification **Gene biotype** Protein coding **Gene family** Myosin light chains, class 1 **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 12 **Protein localisation evidence grade** Approved **Highest tissue expression** 2,518.25 **Tissue specificity (Gini)** 0.971 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:4635 **Reactome pathways** - R-HSA-390522 **Protein interaction confidence** 0.815077 **Protein interaction partners** 39 ## Genomic location **End position** 47227683 **Start position** 47200446 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198336 **HGNC ID** HGNC:7585 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7585) **NCBI Gene ID** 4635 **UniProt ID** P12829 ## Cellular location - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.99912 **Expression inequality (Gini)** 0.971359 ### Highest expression Expression in transcripts per million **Heart - Atrial Appendage** 2,518.25 **Whole Blood** 33.08 **Heart - Left Ventricle** 29.61 **Testis** 19.04 **Thyroid** 8.84 ### All tissues (54) Expression in transcripts per million - Heart - Atrial Appendage2,518.25 - Whole Blood33.08 - Heart - Left Ventricle29.61 - Testis19.04 - Thyroid8.84 - Spleen1.56 - Adipose - Visceral (Omentum)1.49 - Lung1.49 - Adipose - Subcutaneous1.22 - Nerve - Tibial1.22 - Artery - Coronary1.19 - Stomach1.03 - Breast - Mammary Tissue0.99 - Artery - Tibial0.96 - Artery - Aorta0.74 - Esophagus - Gastroesophageal Junction0.69 - Cells - EBV-transformed lymphocytes0.67 - Esophagus - Muscularis0.67 - Prostate0.66 - Uterus0.65 - Bladder0.64 - Muscle - Skeletal0.62 - Small Intestine - Terminal Ileum0.62 - Vagina0.59 - Kidney - Medulla0.59 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0002026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002026) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0060048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060048) ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0031672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031672) ### Molecular functions (2) - GO:0003785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003785) - GO:0051015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051015) ## Related records ### Trials (65) - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Study of CK-1827452 Infusion in Stable Heart Failure - A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) - A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT - A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure - A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants - A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy ### Drugs (3) - Danicamtiv Cardiac myosin activator - [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) Cardiac myosin inhibitor - [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) Cardiac myosin activator --- ## A note for AI agents You are probably reading this for a person. 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