> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/myl2-f5014294-503a-583e-9f48-65c04786cdc4 > Record changed: 2026-10-13 # MYL2 ENSG00000111245 Target class Unclassified protein Chromosome 12 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - CMH10 **Target name** MYL2 **Gene name** Myosin light chain 2 **Gene symbol** MYL2 **Protein name** Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2) ## Classification **Gene biotype** Protein coding **Gene family** Myosin light chains, class 2 **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 50 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 14,495.3 **Tissue specificity (Gini)** 0.961 **Tissue specificity (tau)** 0.984 ## Pathways and interactions **KEGG gene identifiers** - hsa:4633 **Reactome pathways** - R-HSA-390522 **Protein interaction confidence** 0.874693 **Protein interaction partners** 75 ## Genomic location **End position** 111052434 **Start position** 110909996 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000111245 **HGNC ID** HGNC:7583 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7583) **NCBI Gene ID** 4633 **UniProt ID** P10916 ## Cellular location - Cytoplasm, myofibril, sarcomere, A band . ## Tissue expression **Tissue specificity (tau)** 0.984023 **Expression inequality (Gini)** 0.960946 ### Highest expression Expression in transcripts per million **Heart - Left Ventricle** 14,495.3 **Muscle - Skeletal** 12,092.5 **Heart - Atrial Appendage** 47.07 **Minor Salivary Gland** 7.83 **Artery - Aorta** 7.36 ### All tissues (54) Expression in transcripts per million - Heart - Left Ventricle14,495.3 - Muscle - Skeletal12,092.5 - Heart - Atrial Appendage47.07 - Minor Salivary Gland7.83 - Artery - Aorta7.36 - Artery - Coronary5.53 - Nerve - Tibial5.38 - Cells - EBV-transformed lymphocytes4.86 - Artery - Tibial4.77 - Lung4.45 - Skin - Sun Exposed (Lower leg)4.18 - Skin - Not Sun Exposed (Suprapubic)3.89 - Adipose - Subcutaneous3.78 - Esophagus - Gastroesophageal Junction3.7 - Thyroid3.68 - Colon - Sigmoid3.6 - Adipose - Visceral (Omentum)3.42 - Esophagus - Muscularis3.41 - Prostate3.17 - Vagina3.13 - Breast - Mammary Tissue3.11 - Brain - Cortex2.99 - Whole Blood2.84 - Uterus2.71 - Brain - Cerebellum2.66 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006942 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006942) - GO:0030308 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030308) - GO:0055010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055010) ### Cellular components (6) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005856 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005856) - GO:0015629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015629) - GO:0016459 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016459) - GO:0030017 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030017) - GO:0097512 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097512) ### Molecular functions (4) - GO:0003785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003785) - GO:0005509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005509) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008307) ## Related records ### Trials (65) - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Study of CK-1827452 Infusion in Stable Heart Failure - A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) - A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT - A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure - A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants - A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy ### Drugs (3) - Danicamtiv Cardiac myosin activator - [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) Cardiac myosin inhibitor - [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) Cardiac myosin activator --- ## A note for AI agents You are probably reading this for a person. 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